A5101586340- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Risk Factors
- ECG Monitoring and Analysis
- Artificial Intelligence in Healthcare
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Elasticity and Material Modeling
- MRI in cancer diagnosis
- Neural dynamics and brain function
- Machine Learning in Healthcare
- Ion channel regulation and function
- Atrial Fibrillation Management and Outcomes
- Neuroscience and Neural Engineering
- Heart Failure Treatment and Management
- Genetics and Physical Performance
Yuhuangding Hospital
2025
New York Hospital Queens
2024
Presbyterian Hospital
2023-2024
NewYork–Presbyterian Hospital
2024
Columbia University Irving Medical Center
2024
University of Virginia Health System
2023
Centre National de la Recherche Scientifique
2023
Inserm
2023
Institut National des Sciences Appliquées de Lyon
2023
University of Missouri
2023
We investigated the relationship between clinically assessed left ventricular ejection fraction (LVEF) and survival in a large, heterogeneous clinical cohort.
Background: Atrial fibrillation (AF) is associated with substantial morbidity, especially when it goes undetected. If new-onset AF could be predicted, targeted screening used to find early. We hypothesized that a deep neural network predict from the resting 12-lead ECG and this prediction may help identify those at risk of AF-related stroke. Methods: 1.6 M digital traces 430 000 patients collected 1984 2019. Deep networks were trained (within 1 year) in without history AF. Performance was...
BACKGROUND: Artificial intelligence, particularly deep learning (DL), has immense potential to improve the interpretation of transthoracic echocardiography (TTE). Mitral regurgitation (MR) is most common valvular heart disease and presents unique challenges for DL, including integration multiple video-level assessments into a final study-level classification. METHODS: A novel DL system was developed intake complete TTEs, identify color MR Doppler videos, determine severity on 4-step ordinal...
Obesity affects nearly one in five children and is associated with increased risk of premature death. Obesity-related heart disease contributes to We aimed use cardiovascular magnetic resonance (CMR) comprehensively characterize the changes cardiac geometry function obese children. Forty-one obese/overweight (age 12 ± 3 years, 56 % female) 29 healthy weight 14 41 underwent CMR, including both standard cine imaging displacement encoded imaging, for a complete assessment left ventricular (LV)...
Previous studies using regression analyses have failed to identify which patients with repaired tetralogy of Fallot (rTOF) are at risk for deterioration in ventricular size and function despite common clinical cardiac parameters as well mechanics (strain dyssynchrony). This study used a machine learning pipeline comprehensively investigate the predictive value baseline variables derived from magnetic resonance (CMR) imaging provide models identifying deterioration.
Patients with repaired tetralogy of Fallot (TOF) have progressive, adverse biventricular remodeling, leading to abnormal contractile mechanics. Defining the mechanisms underlying this dysfunction, such as diffuse myocardial fibrosis, may provide insights into poor long-term outcomes. We hypothesized that left ventricular (LV) fibrosis is related impaired LV TOF were evaluated cardiac magnetic resonance in which modified Look-Locker (MOLLI) T1-mapping and spiral cine Displacement encoding...
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with variants in desmosome genes. Secondary findings of pathogenic/likely pathogenic variants, primarily loss-of-function (LOF) are recommended for clinical reporting; however, their prevalence and phenotype a general population not fully characterized. Methods: From whole-exome sequencing 61 019 individuals the DiscovEHR cohort, we screened putative PKP2 , DSC2 DSG2 DSP . We evaluated measures from prior ECG...
To develop a three-dimensional (two dimensions + time) convolutional neural network trained with displacement encoding stimulated echoes (DENSE) data for and strain analysis of cine MRI.In this retrospective multicenter study, deep learning model (StrainNet) was developed to predict intramyocardial from contour motion. Patients various heart diseases healthy controls underwent cardiac MRI examinations DENSE between August 2008 January 2022. Network training inputs were time series myocardial...
Children with obesity have hypertrophic cardiac remodeling. Hypertension is common in pediatric obesity, and may independently contribute to hypertrophy. We hypothesized that both the degree of ambulatory blood pressure (ABP) would associate measures remodeling children. Children, aged 8–17 years, prospectively underwent cardiovascular magnetic resonance (CMR) ABP monitoring. Left ventricular (LV) mass indexed height2.7 (LVMI), myocardial thickness end-diastolic volume were quantified from a...
Patients with repaired tetralogy of Fallot (rTOF) suffer from progressive ventricular dysfunction decades after their surgical repair. We hypothesized that measures strain and dyssynchrony would predict deterioration function in patients rTOF. A database search identified all at a single institution rTOF who underwent cardiovascular magnetic resonance (CMR) least twice, >6 months apart, without intervening or catheter procedures. Seven primary predictors were derived the first CMR using...
AimsPatients with repaired tetralogy of Fallot (rTOF) frequently have right bundle branch block. To better understand the contribution cardiac dyssynchrony to dysfunction, we developed a method quantify left (LV), (RV), and inter-ventricular using standard cine magnetic resonance (CMR).
Cardiovascular magnetic resonance (CMR) feature tracking is increasingly used to quantify cardiac mechanics from cine CMR imaging, although validation against reference standard techniques has been limited. Furthermore, studies have suggested that commonly-derived metrics, such as peak global strain (reported in 63% of studies), can be quantified using contours just two frames – end-diastole (ED) and end-systole (ES) without requiring software. We hypothesized derived would not agree with...
The majority of biomedical studies use limited datasets that may not generalize over large heterogeneous have been collected several decades. current paper develops and validates multimodal models can predict 1-year mortality based on a massive clinical dataset. Our focus predicting provide sense urgency to the patients. Using largest dataset its kind, considers development validation 25,137,015 videos associated with 699,822 echocardiography from 316,125 patients, 2,922,990 8-lead...
Displacement Encoding with Stimulated Echoes (DENSE) encodes displacement into the phase of magnetic resonance signal. Due to stimulated echo, signal is inherently low and fades through cardiac cycle. To compensate, a spiral acquisition has been used at 1.5T. This sequence not validated 3T, where increased would be valuable, but field inhomogeneities may result in measurement errors. We hypothesized that cine DENSE valid 3T tested this hypothesis by measuring errors both 1.5T vivo....
Mechanics of the left ventricle (LV) are important indicators cardiac function. The role right ventricular (RV) mechanics is largely unknown due to technical limitations imaging its thin wall and complex geometry motion. By combining 3D Displacement Encoding with Stimulated Echoes (DENSE) a post-processing pipeline that includes local coordinate system, it possible quantify RV strain, torsion, synchrony. In this study, we sought characterize in 50 healthy individuals compare these values...
Cardiovascular magnetic resonance (CMR) of ventricular structure and function is widely performed using cine balanced steady state free precession (bSSFP) MRI. The bSSFP signal myocardium weighted by magnetization transfer (MT) T1/T2-relaxation times. In edematous fibrotic tissues, increased T2 reduced MT lead to intensity on images acquired with high excitation flip angles. We hypothesized that acquisition two differentially MT-weighted (termed 2-point bSSFP) can identify tissue would...
Pediatric obesity is a growing public health problem, which associated with increased risk of cardiovascular disease and premature death. Left ventricular (LV) remodeling (increased myocardial mass thickness) contractile dysfunction (impaired longitudinal strain) have been documented in obese children, but little attention has paid to the right ventricle (RV). We hypothesized that obese/overweight children would evidence RV dysfunction.
Cardiovascular magnetic resonance using displacement encoding with stimulated echoes (DENSE) is capable of assessing advanced measures cardiac mechanics such as strain and torsion. A potential hurdle to widespread clinical adoption DENSE the time required manually segment myocardium during post-processing images. To overcome this hurdle, we proposed a radical approach in which only three contours per image slice are for (instead typical 30–40 slice). We hypothesized that peak left...
Obesity is a risk factor for cardiovascular disease. There evidence of impaired left ventricular (LV) function associated with obesity, which may relate to mortality, but some studies have reported no dysfunction. Ventricular data are generally acquired under resting conditions, could mask subtle differences and potentially contribute these contradictory findings. Furthermore, abnormal mechanics (strains, strain rates, torsion) manifest prior global changes in cardiac (i.e., ejection...