Behavioral research has demonstrated three major components of the lexical-semantic processing system: automatic activation semantic representations, strategic retrieval and inhibition competitors. However, these component processes are inherently conflated in explicit decision tasks typically used functional magnetic resonance imaging (fMRI) research. Here, we combine logic behavioral priming studies neurophysiological phenomenon fMRI to dissociate neural bases across a series studies. A...

ObjectiveThis study aims to add clarity the relationship between deep and periventricular brain white matter hyperintensities (WMHs), cerebral blood flow (CBF), cerebrovascular risk in older persons.MethodsDeep hyperintensity (dWMH) (pWMH) regional gray (GM) (WM) from arterial spin labeling were quantified magnetic resonance imaging scans of 26 cognitively normal elderly subjects stratified by disease (CVD) risk. Fluid-attenuated inversion recovery images acquired using a high-resolution...

Advanced measures of cardiac function are increasingly important to clinical assessment due their superior diagnostic and predictive capabilities. Cine DENSE cardiovascular magnetic resonance (CMR) is ideal for quantifying advanced based on its high spatial resolution streamlined post-processing. While many studies have utilized cine in both humans small-animal models, the inter-test inter-observer reproducibility quantification mice has not been evaluated. This represents a critical...

An improved pre‐clinical cardiac chemical exchange saturation transfer (CEST) pulse sequence (cardioCEST) was used to selectively visualize paramagnetic CEST (paraCEST)‐labeled cells following intramyocardial implantation. In addition, cardioCEST examine the effect of diet‐induced obesity upon myocardial creatine contrast. sequences were designed from standard turbo‐spin‐echo and gradient‐echo sequences, a cardiorespiratory‐gated steady‐state cine sequence. vitro validation studies performed...

BACKGROUND To achieve the best possible outcome in surgical refractory epilepsy, seizure onset zone must be accurately identified prior to treatment. OBSERVATIONS A 38-year-old man presented with tonic-clonic and focal seizures 2–3 times per month, antiseizure medications. Scalp EEG, MRI, PET, ictal SPECT, magnetoencephalography, stereo-EEG (SEEG) did not provide conclusive localization. Subsequently, patient was included authors’ ongoing postictal arterial spin labeling (ASL) study...

Quantitative susceptibility mapping (QSM) is an MRI-based, computational method for anatomically localizing and measuring concentrations of specific biomarkers in tissue such as iron. Growing research suggests QSM a viable evaluating the impact iron overload neurological disorders on cognitive performance aging. Several software toolboxes are currently available to reconstruct maps from 3D GRE MR Images. However, few if any packages exist that offer fully automated pipelines QSM-based data...

Cardiovascular magnetic resonance using displacement encoding with stimulated echoes (DENSE) is capable of assessing advanced measures cardiac mechanics such as strain and torsion. A potential hurdle to widespread clinical adoption DENSE the time required manually segment myocardium during post-processing images. To overcome this hurdle, we proposed a radical approach in which only three contours per image slice are for (instead typical 30–40 slice). We hypothesized that peak left...

White matter (WM) microstructural declines have been demonstrated in Alzheimer's disease and amnestic mild cognitive impairment (aMCI). However, the pattern of WM changes aMCI after controlling for atrophy is unknown. Here, we a

Purpose To test the hypothesis that magnitude images from cine displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) can accurately quantify left ventricular (LV) volumes, mass, and ejection fraction (EF). Materials Methods Thirteen mice (C57BL/6J) were imaged using a 7T ClinScan MRI. A short‐axis stack of T2‐weighted black blood (BB) was acquired for calculation LV EF gold standard sum‐of‐slices methodology. DENSE during same session in three (basal, mid,...

Displacement Encoding with Stimulated Echoes (DENSE) encodes displacement into the phase of magnetic resonance signal. The encoding frequency (ke) maps measured to tissue while strength gradients affects image quality. 2D cine DENSE studies have used a ke 0.10 cycles/mm, which is high enough remove an artifact-generating echo from k-space, provide sensitivity displacements, and dephase blood pool. However, through-plane dephasing can unwanted pool without relying on ke. Additionally, comes...

This article describes the complex relationship between graft, bone, and biologic interference screw. Orthopedic surgeons have just begun to understand this relationship. Clinical outcome measurements tell very little about biology in bone tunnels.

The brain-blood partition coefficient (BBPC) is necessary for quantifying cerebral blood flow (CBF) when using tracer based techniques like arterial spin labeling (ASL). A recent improvement to traditional MRI measurements of BBPC, called calibrated short TR recovery (CaSTRR), has demonstrated a significant reduction in acquisition time BBPC maps mice. In this study CaSTRR applied cohort healthy canines (n = 17, age 5.0 - 8.0 years) protocol suited application humans at 3T. imaging included...

Represents peak strain and twist measured using a particular encoding frequency.**Statistical significance between measures of mechanics paired-sample t-test at level α = 0.05.

Purpose To determine the optimal respiratory navigator gating configuration for quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. Materials and Methods Two‐dimensional DENSE was performed on a 3 Tesla MRI two single‐navigator configurations (retrospective, prospective) combined “dual‐navigator” in 10 healthy adults 20 children. The also underwent breathhold as reference standard comparisons. Peak strains, signal‐to‐noise...

The goal of the study was to develop a novel, rapid Calibrated Short TR Recovery (CaSTRR) method measure brain-blood partition coefficient (BBPC) in mice. BBPC is necessary for quantifying cerebral blood flow (CBF) using tracer-based techniques like arterial spin labeling (ASL), but previous required prohibitively long acquisition times so constant equal 0.9 mL/g typically used regardless studied species, condition, or disease. An accelerated correction could improve regional specificity CBF...

Abstract INTRODUCTION Both micro‐ and macrostructural white matter (WM) abnormalities, particularly those related to axonal degeneration, are associated with cognitive decline in adults Down syndrome (DS) prior a diagnosis of Alzheimer disease. Neurofilament light chain (NfL) is support protein within myelinated axons released into blood following damage. In this study we investigated cross‐sectional relationships between WM microstructural changes as measured by diffusion tensor imaging...

Background Measures of cardiac mechanics such as myocardial wall strain are better predictors outcomes in patients with heart disease compared to traditional clinical measures and ejection fraction. Cine displacement encoding stimulated echoes (DENSE) is an ideal method for quantifying motion which encodes tissue the phase MR signal provides pixellevel resolution mechanics. To date, DENSE has been implemented limited 2-3 pixels across myocardium. While this higher than most other techniques...

<h3>BACKGROUND AND PURPOSE:</h3> Interpretation of fMRI depends on accurate functional-to-structural alignment. This study explores registration methods used by FDA-approved software for clinical and aims to answer the following question: What is degree misalignment when not performed, how well do current perform? <h3>MATERIALS METHODS:</h3> retrospective presurgical brain tumors compares nonregistered images 5 cost functions: Hellinger, mutual information, normalized correlation ratio,...

BackgroundObesity and metabolic syndrome are associated with increased risk of cardiovascular disease.Research suggests that altered cardiac mechanics (i.e., reduced strains, torsion, synchrony contraction) present in obesity; yet, the causes this mechanical dysfunction its relationship to other sequelae obesity (e.g., hypertension elevated blood glucose) not well understood.We hypothesize diet-induced mice leads reductions measures left ventricular (LV) mechanics, which develop acute...