Thierry Le Tourneau
A5039379911- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Antimicrobial Resistance in Staphylococcus
- Congenital Heart Disease Studies
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Pericarditis and Cardiac Tamponade
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Cardiovascular and exercise physiology
Nantes Université
2015-2025
Institut du Thorax
2015-2024
Inserm
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Centre Hospitalier Universitaire de Nantes
2015-2024
Centre d'Investigation Clinique de Nantes
2023
Institute of Cardiology
2023
Mayo Clinic in Arizona
2012-2022
Méditerranée Infection Foundation
2022
Institut de Recherche pour le Développement
2022
Aortic-valve stenosis can be complicated by bleeding that is associated with acquired type 2A von Willebrand syndrome. However, the prevalence and cause of hemostatic abnormality in aortic are unknown.We enrolled 50 consecutive patients stenosis, who completed a standardized screening questionnaire to detect history bleeding. Forty-two severe underwent valve replacement. Platelet function under conditions high shear stress, factor collagen-binding activity antigen levels, multimeric...
Functional tricuspid regurgitation (FTR) with structurally normal valve is of poorly defined mechanisms. Prevalence and clinical context idiopathic FTR (Id-FTR) (without overt TR cause) are unknown.To investigate prevalence, context, mechanisms specific to types, Id-FTR versus pulmonary hypertension-related (PHTN-FTR, systolic pressure ≥50 mm Hg), we analyzed 1161 patients prospectively quantified TR. (prevalence 12%) was associated aging atrial fibrillation. For mechanistic purposes,...
Aims Abnormal exercise test defined as the occurrence of limiting symptoms, fall in blood pressure below baseline, or complex ventricular arrhythmias is useful to predict clinical events asymptomatic patients with aortic stenosis (AS). The purpose this study was determine whether exercise-stress echocardiography (ESE) adds any incremental prognostic value resting AS having a normal response. Methods and results One hundred eighty-six at least moderate preserved LV ejection fraction (>/=50%)...
Isolated tricuspid valve surgery (ITVS) is considered to be a high-risk procedure, but in-hospital mortality markedly variable. This study sought develop dedicated risk score model predict the outcome of patients after ITVS for severe regurgitation (TR).
Abstract Aims The aim of this study was to identify determinants in-hospital and mid-term outcomes after isolated tricuspid valve surgery (ITVS) more specifically the impact regurgitation (TR) mechanism clinical presentation. Methods results Among 5661 consecutive adult patients who underwent a (TV) at 12 French tertiary centres in 2007–2017 collected from mandatory administrative database, we identified 466 (8% all surgeries) an ITVS. Most presented with advanced disease [47% New York Heart...
Background: Mitral valve prolapse (MVP) is a frequent disease that can be complicated by mitral regurgitation (MR), heart failure, arterial embolism, rhythm disorders, and death. Left ventricular (LV) replacement myocardial fibrosis, marker of maladaptive remodeling, has been described in patients with MVP, but the implications this finding remain scarcely explored. We aimed at assessing prevalence, pathophysiological prognostic significance LV fibrosis through late gadolinium enhancement...
Abstract Background and aims Benefit of tricuspid regurgitation (TR) correction timing intervention are unclear. This study aimed to compare survival rates after surgical or transcatheter conservative management according a TR clinical stage as assessed using the TRI-SCORE. Methods A total 2,413 patients with severe isolated functional were enrolled in TRIGISTRY (1217 conservatively managed, 551 valve surgery, 645 repair). The primary endpoint was at 2 years. Results TRI-SCORE low (≤3) 32%,...
Structural valve deterioration (SVD) is a major flaw of bioprostheses. Early SVD has been suspected in the last models Mitroflow bioprosthesis. We sought to assess incidence, mode, and impact on outcome large series aortic replacement.Six hundred seventeen consecutive patients (aged 76.1±6.3 years) underwent replacement with prosthesis (models 12A/LX) between 2002 2007. By echocardiography, 39 developed early (1.66% per patient-year), stenosis as main mode (n=36). Mean delay was only 3.8±1.4...
Intracoronary administration of autologous bone marrow cells (BMCs) leads to a modest improvement in cardiac function, but the effect on myocardial viability is unknown. The aim this randomized multicentre study was evaluate BMC therapy patients with decreased left ventricular ejection fraction (LVEF) after acute infarction (AMI) and identify predictive factors for viability. One hundred one AMI successful reperfusion, LVEF ≤45%, (resting Tl201-SPECT) were either control group (n = 49) or...
<h3>Objective</h3> To evaluate the predictors of pulmonary artery systolic pressure (PASP) in organic mitral regurgitation (MR) and its prognostic value after surgery. <h3>Design</h3> Prospective observational study, conducted from 1998 to 2006. <h3>Setting</h3> Echocardiography cardiac surgery departments, University Hospital. <h3>Patients</h3> was carried out 256 patients (63±12 years, 170 male) with MR (degenerative aetiology: 91%) referred for <h3>Main outcome measures</h3> PASP....
Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral surgery. MVP can cause arrhythmias, heart failure, sudden cardiac death, to date, causes of this disease are poorly understood. We now demonstrate that defects primary cilia genes their regulated pathways familial sporadic nonsyndromic cases. Our expression studies genetic ablation experiments confirmed a role regulating ECM deposition during development. Loss development resulted progressive...
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased but their susceptibility structural valve degeneration (SVD) limits use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly the xenoantigens galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc), could mediate deterioration through calcification. established a large longitudinal prospective international cohort of patients (n = 1668, 34 ±...
Abstract Background and Aims Severe tricuspid regurgitation is associated with increased mortality rates, but benefit of its correction ideal timing are not clearly determined. This study aimed to identify patient subsets who might from the surgery. Methods In TRIGISTRY, an international cohort consecutive patients severe isolated functional (33 centres, 10 countries), survival rates up years were compared between underwent valve surgery (repair or replacement) those conservatively managed,...
To assess the prevalence, determinants, and prognosis value of right ventricular (RV) ejection fraction (EF) impairment in organic mitral regurgitation.Two hundred eight patients (62±12 years, 138 males) with chronic regurgitation referred to surgery underwent an echocardiography biventricular radionuclide angiography regional function assessment. Mean RV EF was 40.4±10.2%, ranging from 10% 65%. severely impaired (≤35%) 63 (30%), (left EF<60% EF≤35%) found 34 (16%). Pathophysiologic...
We hypothesized that the structure and function of mature valves is largely dependent upon how these tissues are built during development, defects in can lead to pathological progression a disease phenotype. Thus, we sought uncover potential developmental origins mechanistic underpinnings causal myxomatous mitral valve disease. focus on filamin-A, cytoskeletal binding protein with strong links human disease, as regulatory interface control proper development. Filamin-A-deficient mice exhibit...