A5102009144- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Estrogen and related hormone effects
- Respiratory Support and Mechanisms
- Allergic Rhinitis and Sensitization
- Mobile Health and mHealth Applications
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Adrenal Hormones and Disorders
- Family and Patient Care in Intensive Care Units
- Esophageal and GI Pathology
- Health, Environment, Cognitive Aging
- Pleural and Pulmonary Diseases
- Urticaria and Related Conditions
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Healthcare Technology and Patient Monitoring
- Infection Control in Healthcare
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Hormonal Regulation and Hypertension
- Inflammatory mediators and NSAID effects
- Food Allergy and Anaphylaxis Research
Tallaght University Hospital
2013-2024
Trinity College Dublin
2024
Bristol-Myers Squibb (United States)
2023
Vhi Healthcare
2017
National Maternity Hospital
2016
Amron (United States)
2004-2008
GlaxoSmithKline (United Kingdom)
2006
Hokkaido University
2005
Johns Hopkins University
2004
Research Triangle Park Foundation
2000
In severe asthma, poor control could reflect issues of medication adherence or inhaler technique, that the condition is refractory. This study aimed to determine if an intervention with (bio)feedback on features use would identify refractory asthma and enhance technique adherence.Patients uncontrolled were subjected a stratified-by-site random block design. The intensive education group received repeated training in use, disease management. same intervention, enhanced by (bio)feedback-guided...
Glucocorticosteroids are a very effective treatment for asthma and other chronic inflammatory diseases. However, small proportion of patients is resistant to the therapeutic effects glucocorticoids. Pharmacokinetic ligand binding studies suggest that molecular abnormality in steroid resistance lies distal nuclear translocation. We have previously reported there decreased ability glucocorticoid receptors (GR) bind DNA-binding site peripheral blood mononuclear cells (PBMC) after dexamethasone...
Macrophage migration inhibitory factor (MIF) is an immunologic regulator that expressed in inflammatory and autoimmune disorders. We investigated MIF's role asthma using genetic approaches a mouse model cohort of patients. Mice genetically deficient MIF were primed aerosol-challenged with ovalbumin showed less pulmonary inflammation lower airway hyperresponsiveness than matched, wild-type controls. deficiency also resulted titers specific IgE, IgG(1), IgG(2a), decreased pulmonary, T(H)2...
To determine whether electronic monitoring of hand hygiene and voice prompts can improve decrease nosocomial infection rates in a surgical intermediate care unit.Three-phase quasi-experimental design. Phase I was direct observation; phase II computerized for failure to perform on room exit; III only.Nine-room, 14-bed unit university, tertiary-care institution. All patient rooms, utility room, staff lavatory were monitored electronically.All healthcare personnel including physicians, nurses,...
BACKGROUND: There are two isoforms of cyclo-oxygenase (COX), namely COX-1 and COX-2. is constitutively expressed in most tissues blood platelets. The metabolites derived from probably involved cellular housekeeping functions. COX-2 only following activation by inflammatory stimuli thought to be inflammation. METHODS: expression isoenzymes has been studied the bronchial mucosa 10 normal 18 asthmatic subjects, 11 whom had aspirin-sensitive asthma (ASA) seven non-aspirin-sensitive (NASA)...
Although glucocorticosteroids are a very effective treatment for asthma and other chronic inflammatory diseases, small proportion of patients resistant to their therapeutic effects. The molecular mechanism this steroid resistance is unclear. Steroid cannot be explained by pharmacokinetic mechanisms, defect in the binding steroids glucocorticoid receptors, nor defective nuclear translocation receptor, thereby suggesting that abnormality lies distal translocation. We examined ability...
Unstimulated peripheral blood mononuclear cells (PBMCs) from corticosteroid-resistant (CR) but not corticosteroid-sensitive (CS) asthmatics demonstrate increased activating peptide-1 (AP-1)- and decreased glucocorticoid receptor (GR)-DNA binding. We test whether these abnormalities are associated with excessive generation of c-fos, the inducible component AP-1. The c-fos transcription rate, mRNA protein levels, GR-DNA binding were quantitated in PBMCs, T cells, monocytes CS, CR, nonasthmatic...
Accumulating evidence suggests that the cytokine network is central to immunopathology of bronchial asthma and recent findings have suggested naturally occurring antagonists may also be involved. In this study we looked at expression interleukin-1 beta (IL-1beta) its receptor antagonist, IL-1ra, in normal asthmatic wall. Frozen biopsies from 12 18 individuals were double stained with EBM11 (a CD68 macrophage marker) either a rabbit anti-IL-1beta or anti-IL-1ra. Hue-saturation-intensity color...
Hemodynamic abnormalities have been implicated in the pathogenesis of increased glomerular permeability to protein diabetic and other glomerulopathies. Vascular factor (VPF) is one most powerful promoters vascular permeability. We studied effect stretch on VPF production by human mesangial cells intracellular signaling pathways involved. The application mechanical (elongation 10%) for 6 h induced a 2.4-fold increase over control mRNA level (P < 0.05). There was corresponding 3-fold 12 0....
Dual bronchodilation combining a long-acting β2-agonist (LABA) and muscarinic antagonist (LAMA) is the preferred choice of treatment recommended by Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 guidelines management patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). The once-daily (q.d.) fixed-dose combination (FDC) LABA, indacaterol 110 μg LAMA, glycopyrronium 50 (IND/GLY 110/50 q.d.) demonstrated superior improvements in lung function,...
Corticosteroid-resistant (CR) asthma is not caused by altered bioavailability of the administered drug, ligand-binding characteristics, or nuclear translocation activated human glucocorticoid receptor (hGR) complex. We have tested hypothesis that CR results from a consistent polymorphism in functionally diverse hGR cDNA using sensitive screening technique polymerase chain reaction (PCR) amplification and chemical mutational analysis. Total RNA was extracted peripheral blood monocytes derived...
BACKGROUND: Accumulating evidence suggests that the cytokine network is central to immunopathology of bronchial asthma and existence naturally occurring antagonists has added this complexity. Upregulation both interleukin 1 beta (IL-1 beta) its receptor antagonist, antagonist (IL-1ra), previously been observed on asthmatic epithelium compared with normal airways. METHODS: The effect inhaled beclomethasone dipropionate (BDP) epithelial expression IL-1 IL-1ra was studied. Frozen biopsy...
This proof-of-concept study retrospectively assessed the feasibility of applying a hybrid control arm design to completed phase III randomized controlled trial (RCT; CheckMate-057) in advanced non-small cell lung cancer using real-world data (RWD) source. The emulated consists an experimental (patients from RCT cohort) and RWD cohorts). For cohort, this used nationwide electronic health record-derived de-identified database. Three frequentist statistical borrowing methods were evaluated:...
<i>Background:</i> Atopic asthma is an allergic disease typically associated with T<sub>H</sub>2 cytokines. IL-17A also asthma, through the induction of chemokines. Mucosal CCL28 concentrations correlate cellular recruitment to inflamed airways and support migration IgA<sup>+</sup> B cells. Here, a link between IL-17A, IgE-secreting cell chemotaxis examined. <i>Methods:</i> Primary human airway cells epithelial line A549 were used characterize...