A5101411247- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- Dermatological and Skeletal Disorders
- Caveolin-1 and cellular processes
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Multiple Myeloma Research and Treatments
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Cancer Genomics and Diagnostics
- Alzheimer's disease research and treatments
- Marine and fisheries research
- Parathyroid Disorders and Treatments
- Cell Adhesion Molecules Research
- Molecular Biology Techniques and Applications
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Marine and coastal ecosystems
- Monoclonal and Polyclonal Antibodies Research
- Ichthyology and Marine Biology
- Tissue Engineering and Regenerative Medicine
- Neuroendocrine Tumor Research Advances
- Pediatric Urology and Nephrology Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Cephalopods and Marine Biology
University of South Alabama
2019-2025
Pontificia Universidad Católica de Chile
1984-2024
University of Alabama at Birmingham Hospital
2023
Louisiana State University
1997-2021
Louisiana State University Health Sciences Center Shreveport
2005-2019
University of California, Davis
2019
Louisiana State University in Shreveport
1997-2018
Universidad de Granada
2012-2017
Amyloidosis Foundation
2015
University of Alabama
1986-2015
Human mesangial cells (HMCs) are injured by either excessive amounts or abnormal light chains (LCs), a combination of both in patients with plasma cell dyscrasias. Consequently, these HMCs undergo phenotypic transformations. were incubated eight different light-chains (LCs) for 96 h. These cells, addition to 51 patient samples from AL-amyloidosis (AL-Am), light-chain deposition disease (LCDD), myeloma cast nephropathy (MCN) and controls analyzed immunohistochemistry CD68, muscle-specific...
Abstract Context.—Renal dysfunction in plasma cell dyscrasias is common. It the second most common cause of death patients with myeloma. Objective.—We evaluated 77 sequential autopsies performed on dying from complications during an 11-year period at University Arkansas for Medical Sciences. These consisted 15% all this time. Design.—The kidneys were by light microscopy using hematoxylin-eosin–stained sections as well Congo red and thioflavin T stains when amyloidosis was differential...
Background. Renal amyloidosis is associated with a variety of underlying disease processes. Although amyloid identical in appearance these diseases, the precursor proteins are different. Immunofluorescence microscopy has been used as primary tool diagnostic evaluation cause renal AL-amyloidosis. The purpose this study was to document sensitivity immunofluorescence
Abstract Context.—Most renal diseases with organized deposits are relatively uncommon conditions, and proper pathologic characterization determines the specific diagnosis. Different entities clinical correlates have been recognized, their correct diagnosis has an impact on patient management, treatment options, determination of prognosis. Objective.—The these conditions depends careful evaluation findings by light microscopy together immunofluorescence electron microscopy. The objective this...
Context.—Lesions associated with monoclonal light and heavy chains display a variety of glomerular, tubular interstitial, vascular manifestations. While some the entities are well recognized, including chain deposition diseases, AL (light chain) AH (heavy amyloidosis, (“myeloma”) cast nephropathy, other lesions centered on proximal tubules much less accurately identified, properly diagnosed, adequately understood in terms pathogenesis molecular mechanisms involved. These tubule–centered...
and principles in the interpretation of results. With emergence markedly different treatments, largely directed against specific types amyloid, typing is increasing clinical relevance should, therefore, be performed with great care.
Abstract Context.—Patients with plasma cell dyscrasias (myeloma) may exhibit a variety of renal manifestations as result damage from circulating light- and heavy-chain immunoglobulin components produced by the neoplastic cells. The alterations can occur in any compartments, significant number cases more than one compartment is affected. Research laboratory has helped considerably providing solid conceptual understanding how occurs. Objectives.—To detail advances that have been made diagnosis...
Our purpose was to evaluate the feasibility of performing fluorescence in situ hybridization (FISH) on routine urine samples and compare relative sensitivities cytology FISH for detecting urothelial carcinoma. Light microscopy (LM) using cytologic evaluation were used study 121 consecutive samples. A mixture fluorescent probes chromosomes 3, 7, 17, 9p21 locus detection numerical chromosomal abnormalities (UroVysion, Vysis/Abbott). Biopsy specimens from patients reviewed if available....