A5072604377- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Adolescent and Pediatric Healthcare
- Sex and Gender in Healthcare
- Neurological Complications and Syndromes
- Mental Health and Patient Involvement
- Diversity and Career in Medicine
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Organ and Tissue Transplantation Research
- Dialysis and Renal Disease Management
- Sodium Intake and Health
- Ethics in Clinical Research
- T-cell and B-cell Immunology
- Ophthalmology and Eye Disorders
- Pharmacological Effects and Toxicity Studies
McGill University
2016-2025
McGill University Health Centre
2016-2025
Royal Victoria Hospital
2016-2025
Royal Victoria Regional Health Centre
2016-2025
Translational Research in Oncology
2021-2024
Liechtenstein Institute
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Peter MacCallum Cancer Centre
2022
Université de Montréal
2022
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of American Society Histocompatibility and Immunogenetics Pittsburgh, PA (USA) focused on refining recent updates to classification, advances from working groups, standardization molecular diagnostics. This report kidney transplant details clarifications refinements criteria chronic active (CA) T cell–mediated rejection (TCMR), borderline, antibody-mediated (ABMR). main focus sessions how address...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark 30th anniversary first Classification, pre-meeting discussions were on past, present, and future Classification. This report is summary highlights that most important terms their effect including around microvascular inflammation biopsy-based transcript analysis diagnosis. In post-meeting survey, agreement...
Prior studies of sex differences in kidney graft survival showed conflicting results. We hypothesized that the association between recipient and failure risk differs by age donor sex. evaluated 159,417 patients recorded Scientific Registry Transplant Recipients database who received a first deceased-donor transplant (1995-2013). used time-varying Cox models to estimate death-censored failure. Models, stratified on adjusted for potential confounders, included current interaction term. Among...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to key focus on impact microvascular inflammation and biopsy-based transcript analysis Classification, further sessions were devoted other aspects kidney transplant pathology, particular T cell-mediated rejection, activity chronicity indices, digital xenotransplantation, clinical trials, surrogate...
Cardiovascular mortality is the leading cause of death in ESRD. Whereas innate and adaptive immunity have established roles cardiovascular disease, role humoral unknown. We conducted a retrospective cohort study first-time adult kidney transplant candidates (N=161,308) using data from Scientific Registry Transplant Recipients Centers for Medicare Medicaid Services to evaluate whether anti-human leukocyte antigen antibodies, measured as panel reactive antibodies (PRAs), are related...
Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). Vaccination may mitigate this risk; however, immunogenicity appears to be significantly impaired, with reports of increased breakthrough infection. It is unknown if vaccine infections milder or as severe in unvaccinated patients.
<h3>Background:</h3> Severe COVID-19 appears to disproportionately affect people who are immunocompromised, although Canadian data in this context limited. We sought determine factors associated with severe outcomes among recipients of organ transplants across Canada. <h3>Methods:</h3> performed a multicentre, prospective cohort study all solid from 9 transplant programs Canada received diagnosis March 2020 November 2021. Data were analyzed risk for oxygen requirement and other metrics...
The aim of this study was to determine how the Banff antibody-mediated rejection (ABMR) classification for kidney transplantation is interpreted in practice and affects therapy. Antibody-Mediated Injury Workgroup electronically surveyed clinicians pathologists worldwide regarding diagnosis treatment 6 case-based scenarios. participants' (95 72 renal pathologists) assigned diagnoses were compared intended (reference standard). reference standard differed by 26.1% (SD 28.1%) 34.5% 23.3%)...
To mitigate risks related to human leukocyte antigen (HLA) incompatibility, we assessed whether certain structurally defined HLA targets present in donors but absent from recipients, known as eplet mismatches (EMM), are associated with death-censored graft failure (DCGF).We studied a cohort of 118,313 American 0% panel reactive antibodies (PRA) first kidney transplant recipients (2000 2015) the Scientific Registry Transplant Recipients. Imputed allele-level donor and recipient HLA-A, -B, -C,...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark 30th anniversary first Classification, pre-meeting discussions were on past, present, and future Classification. This report is summary highlights that most important terms their effect Classification - around microvascular inflammation biopsy-based transcript analysis diagnosis. In post-meeting survey,...
ABSTRACT Introduction The diagnosis of antibody‐mediated rejection (AMR) requires input from several transplant professionals. Bringing clinical and laboratory experts together may help standardize care. Yet, little is known about current global practices multidisciplinary meetings for AMR management. Methods Banff Antibody‐Mediated Injury Working Group approached professional societies worldwide to distribute a survey on the availability, content, participants, perceived value, barriers...
<title>Abstract</title> Organ allocation to minimize Human Leukocyte Antigens (HLA) disparity between donor and recipient has been shown improve outcomes but is limited by the enormous HLA diversity. PIRCHE-II in silico model considers peptide binding characteristics of recipients quantitate molecular compatibility. We have applied a simplified match algorithm well characterised nested population-based cohort ~1500 heterogenous renal patients donors develop basic simulate optimised kidney...