A5048194032- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Pregnancy and Medication Impact
- Dialysis and Renal Disease Management
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- Medical Image Segmentation Techniques
- Complement system in diseases
- Medical Imaging Techniques and Applications
- Blood Pressure and Hypertension Studies
- HIV/AIDS drug development and treatment
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Advanced Radiotherapy Techniques
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical Practices and Patient Outcomes
Centre Hospitalier de l’Université de Montréal
2016-2025
Université de Montréal
2013-2025
Translational Research in Oncology
2019-2025
University of Alberta
2024
Hôpital Maisonneuve-Rosemont
2006-2023
Occupational Cancer Research Centre
2023
Héma-Québec
2023
Canadian Natural Resources
2015-2022
Peter MacCallum Cancer Centre
2022
The University of Melbourne
2022
Exosome-like vesicles containing an active 20 S proteasome core contribute to autoimmunity and vascular allograft inflammation.
Acute vascular rejection (AVR) is characterized by immune-mediated injury and heightened endothelial cell (EC) apoptosis. We reported previously that apoptotic ECs release a bioactive C-terminal fragment of perlecan referred to as LG3. Here, we tested the possibility LG3 behaves neoantigen, fuelling production anti-LG3 antibodies potential importance in regulating allograft injury. performed case–control study which compared IgG titers kidney transplant recipients with AVR (n = 15) versus...
Prior studies of sex differences in kidney graft survival showed conflicting results. We hypothesized that the association between recipient and failure risk differs by age donor sex. evaluated 159,417 patients recorded Scientific Registry Transplant Recipients database who received a first deceased-donor transplant (1995-2013). used time-varying Cox models to estimate death-censored failure. Models, stratified on adjusted for potential confounders, included current interaction term. Among...
We propose the use of conic and cubic surface equations (surfaces second third order) to directly approximate dual‐energy (the integral for log‐signal functions, i.e., negative logarithms relative detector signals, considered as functions basis‐material component thicknesses object) especially their inverses. These types require a minimum number calibration points, solutions are smooth, monotonic with correct linear asymptotic behavior. The accuracy this method is investigated compared that...
Commercial intact parathyroid hormone (I-PTH) assays detect molecular form(s) of human PTH, non-(1-84) different from the 84-amino acid native molecule. These accumulate in hemodialyzed patients. We investigated importance PTH interpretation increased I-PTH progressive renal failure.Five groups were studied: 26 healthy individuals, 12 patients, and 31 patients with failure subdivided according to their glomerular filtration rate (GFR) into 11 a GFR between 60 100 mL. min(-1). 1.73 m(-2), 30...
Rationale: Endothelial apoptosis is increased in association with acute and chronic vascular rejection (VR) of solid allografts. Apoptotic endothelial cells (EC) release LG3, a C-terminal fragment perlecan potential importance remodeling neointima formation. Objective: Our 2 goals were to determine whether circulating levels LG3 are VR renal allografts evaluate the impact on remodeling. Methods Results: We conducted case-control study compare serum human transplant patients VR,...
Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid organ transplant (SOT) recipients. In this case-control study, we determined the association between posttransplant PCP 3 variables: cytomegalovirus (CMV) infection, allograft rejection, prophylaxis. Eight centers participated. For each case (SOT recipient PCP), 3–5 controls recipients without PCP) were included. Controls matched to cases based on center, type of allograft, date transplantation (±6 months). We...
Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). Vaccination may mitigate this risk; however, immunogenicity appears to be significantly impaired, with reports of increased breakthrough infection. It is unknown if vaccine infections milder or as severe in unvaccinated patients.
<h3>Background:</h3> Severe COVID-19 appears to disproportionately affect people who are immunocompromised, although Canadian data in this context limited. We sought determine factors associated with severe outcomes among recipients of organ transplants across Canada. <h3>Methods:</h3> performed a multicentre, prospective cohort study all solid from 9 transplant programs Canada received diagnosis March 2020 November 2021. Data were analyzed risk for oxygen requirement and other metrics...
In this paper, we report on two methods for semiautomatic three-dimensional (3-D) prostate boundary segmentation using 2-D ultrasound images. For each method, a 3-D image was sliced into the series of contiguous images, either in parallel manner, with uniform slice spacing 1 mm, or rotational about an axis approximately through center prostate, angular 5°. The process initiated by manually placing four points selected slice, from which initial determined. This refined Discrete Dynamic...
Introduction: Delayed graft function (DGF), defined as the needfor dialysis during first week after renal transplantation, is animportant adverse clinical outcome. A previous model relied on16 variables to quantify risk of DGF, thereby undermining itsclinical usefulness. We explored possibility developing asimpler, equally accurate and more user-friendly paradigm forrenal transplant recipients from deceased donors.Methods: Logistic regression analyses addressed occurrenceof DGF in 532...
Little is known about the risk of venous thrombosis following kidney transplant. To determine this we estimated thromboembolic events (TEs) in a cohort consecutive patients who underwent transplantation at single tertiary care center over an 11-year period and calculated standardized incidence ratios (SIRs) for first TE transplant recipients compared with general population. We then performed nested case-control study without TEs to identify factors thrombosis. Among 913 (KTRs), 68 developed...
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care patients. In this paper, we propose a deep learning method that directly models function instead estimating hazard predict times for patients based on principle multi-task learning. By jointly time event, its rank cox partial log likelihood framework, our approach outperforms, terms prediction quality concordance index, other common methods analysis,...
Pretransplant autoantibodies to LG3 and angiotensin II type 1 receptors (AT1R) are associated with acute rejection in kidney transplant recipients, whereas antivimentin participate heart rejection. Ischemia–reperfusion injury (IRI) can modify self-antigenic targets. We hypothesized that ischemia–reperfusion creates permissive conditions for interact their antigenic targets leads enhanced renal damage dysfunction. In 172 we found pretransplant anti-LG3 antibodies were an increased risk of...