A5033488285- Renal Transplantation Outcomes and Treatments
- Neurological Complications and Syndromes
- Stellar, planetary, and galactic studies
- Organ Transplantation Techniques and Outcomes
- Astro and Planetary Science
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Transplantation: Methods and Outcomes
- Astrophysics and Star Formation Studies
- Renal Diseases and Glomerulopathies
- Astronomy and Astrophysical Research
- Pharmacological Effects and Toxicity Studies
- HIV Research and Treatment
- Pregnancy and Medication Impact
- Gamma-ray bursts and supernovae
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal and Vascular Pathologies
- Muscle and Compartmental Disorders
- Organ Donation and Transplantation
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Immunodeficiency and Autoimmune Disorders
- HIV-related health complications and treatments
Hôpital Pellegrin
2025
Médecins du Monde
2025
Hôpital Paul-Brousse
2025
Centre Hospitalier de Tourcoing
2017-2024
McGill University
2006-2024
Université de Montréal
1997-2023
Hôpital Maisonneuve-Rosemont
2009-2022
Institut Pasteur
2021
Centre Hospitalier Universitaire de Montpellier
2020
Université de Montpellier
2020
Background. The safety, tolerability, and pharmacokinetics of conventional cyclosporine (ConCsA) microemulsion (MeCsA) were compared under conditions normal clinical practice in a prospective, randomized, concentration-controlled, pharmacoepidemiologic study. Methods. Between September 1994 March 1995, 1097 stable renal transplant recipients 14 Canadian centers randomized 2:1 to treatment with MeCsA or ConCsA. Patients commenced on each study drug at dose equal their previous therapy ConCsA,...
We conducted a randomized, multicenter study to determine whether treatment of subclinical rejection with increased corticosteroids resulted in beneficial outcomes renal transplant patients receiving tacrolimus (TAC), mycophenolate mofetil (MMF) and prednisone. One hundred twenty‐one were randomized biopsies at 0,1,2,3 6 months (Biopsy arm), 119 0 only (Control arm). The primary endpoint the was prevalence sum interstitial tubular scores (ci + ct) > 2 (Banff) months. Secondary endpoints...
We present the discovery of a comoving planetary-mass companion ∼42'' (∼2000 AU) from young M3 star, GU Psc, likely member AB Doradus Moving Group (ABDMG). The was first identified via its distinctively red i − z color (>3.5) through survey made with Gemini-S/GMOS. Follow-up Canada–France–Hawaii Telescope/WIRCam near-infrared (NIR) imaging, Gemini-N/GNIRS NIR spectroscopy and Wide-field Infrared Survey Explorer photometry indicate spectral type T3.5 ± 1 reveal signs low gravity which we...
Precise measurements of chemical abundances in planetary atmospheres are necessary to constrain the formation histories exoplanets. A recent study WASP-127b, a close-in puffy sub-Saturn orbiting its solar-type host star 4.2 d, using HST and Spitzer revealed feature-rich transmission spectrum with strong excess absorption at 4.5 um. However, limited spectral resolution coverage these instruments could not distinguish between CO and/or CO2 causing this signal, both low high C/O ratio scenarios...
The distribution of close-in exoplanets is shaped by a complex interplay between atmospheric and dynamical processes. Desert-Rim Exoplanets Atmosphere Migration (DREAM) program aims at disentangling those processes through the study hot Neptune desert, whose rim hosts planets that are undergoing, or survived, evaporation orbital migration. In this first paper, we use Rossiter-McLaughlin revolutions (RMR) technique to investigate architecture 14 ranging from mini-Neptune Jupiter-size covering...
Hyperlipidemia appears to play an integral role in loss of glucose-stimulated insulin secretion (GSIS) type 2 diabetes. This impairment can be simulated vitro by chronic culture 832/13 insulinoma cells with high concentrations free fatty acids, or study lipid-laden islets from Zucker diabetic rats. Here we show that impaired GSIS is not a simple result saturation lipid storage pathways, as adenovirus-mediated overexpression cytosolically localized variant malonyl-CoA decarboxylase either...
Soluble leptin receptor (SLR) represents the major binding activity in plasma. It is generated by alternative splicing of OB-R mRNA (OB-Re) and/or ectodomain shedding membrane-spanning receptors. To determine role SLR activation its long-form receptor, OB-Rb, we established vitro assays using a cell line stably expressing OB-Rb. Human embryonic kidney 293 lines overexpressing OB-Rb show dose-dependent leptin-induced signal transducer and activator transcription 3 (STAT3) tyrosine...
The metastable helium triplet in the near-infrared (10833{\AA}) is among most important probes of exoplanet atmospheres. It can trace their extended outer layers and constrain mass-loss. We use high-resolution spectropolarimeter SPIRou on CFHT to search for spectrally resolved atmospheres eleven exoplanets, ranging from warm mini-Neptunes hot Jupiters orbiting G, K, M dwarfs. Observations were obtained as part Legacy Survey complementary open-time programs. apply a homogeneous data reduction...
Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid organ transplant (SOT) recipients. In this case-control study, we determined the association between posttransplant PCP 3 variables: cytomegalovirus (CMV) infection, allograft rejection, prophylaxis. Eight centers participated. For each case (SOT recipient PCP), 3–5 controls recipients without PCP) were included. Controls matched to cases based on center, type of allograft, date transplantation (±6 months). We...
Abstract We present a photometric detection of the first brightness dips unique variable star KIC 8462852 since end Kepler space mission in 2013 May. Our regular surveillance started 2015 October, and sequence dipping began 2017 May continuing on through 2017, when was no longer visible from Earth. distinguish four main 1%–2.5% dips, named “ Elsie ,” Celeste Skara Brae Angkor which persist timescales several days to weeks. results so far are as follows: (i) there apparent changes stellar...
We present the first exoplanet atmosphere detection made as part of SPIRou Legacy Survey, a Large Observing Program 300 nights exploiting capabilities SPIRou, new near-infrared high-resolution (R ~ 70 000) spectro-polarimeter installed on Canada-France-Hawaii Telescope (CFHT; 3.6-m). observed two transits HD 189733, an extensively studied hot Jupiter that is known to show prominent water vapor absorption in its transmission spectrum. When combining transits, we successfully detect planet's...
While NLRC4-dependent sensing of intracellular Gram-negative pathogens such as Salmonella enterica serovar typhimurium is a beneficial host response, the Pseudomonas aeruginosa type 3 secretion system (T3SS) has been shown to be involved in pathogenicity. In mice, different pathogen-associated microbial patterns are sensed by combination NLRC4-inflammasome with neuronal apoptosis inhibitory proteins (NAIPs). NAIP2 PscI, an inner-rod protein P. T3SS. Surprisingly, only single human NAIP...
Abstract A determination of the initial mass function (IMF) current, incomplete census 10 Myr-old TW Hya association (TWA) is presented. This built from a literature compilation supplemented with new spectra and 17 radial velocities ongoing membership surveys, as well reanalysis Hipparcos data that confirmed HR 4334 (A2 Vn) member. Although dominant uncertainty in IMF remains incompleteness, detailed statistical treatment carried out to make independent binning while accounting for small...
We present the results of a search for new circumstellar disks around low-mass stars and brown dwarfs with spectral types >K5 that are confirmed or candidate members nearby young moving groups. Our input sample was drawn from BANYAN surveys Malo et al. Gagn\'e Two-Micron All-Sky Survey Wide-field Infrared Explorer data were used to detect near- mid-infrared excesses would reveal presence disks. A total 13 targets convincing identified: four nine already known in literature. The candidates...
There has been concern that the increased drug exposure associated with treatment cyclosporine microemulsion (CsA-ME) would lead to an increase in adverse events.The long-term safety and tolerability of conventional (CsA) CsA-ME were compared a randomized, multicenter, pharmacoepidemiologic study involving 1097 stable renal transplant patients after 18 months follow-up.No significant difference was seen change serum creatinine or calculated clearance between two groups. Episodes...
Conversion from a calcineurin-inhibitor-based immunosuppression to rapamycin-based may preserve kidney graft function. The side effects of rapamycin can limit its usefulness, but their management and evolution are rarely reported in clinical trials. We performed retrospective cohort study patients transplanted before December 31, 2008 who received replace calcineurin inhibitors. In 219 studied, 98% presented ≥1 after starting rapamycin. Side occurring ≥10% were dyslipidemia (52%, 95%...
Meeting donor management goals (DMGs) has been reported to decrease the incidence of delayed graft function (DGF) after kidney transplant, but whether this relationship is independent cold machine perfusion unclear. We aimed determine meeting DMGs associated with a reduced DGF, use perfusion. collected data on consecutive brain-dead donors and their KT recipients (KTRs) between June 2013 December 2016 in 5 adult transplant centers. evaluated were met at neurologic death (DND) later time...
Recombinant human erythropoietin (rHuEPO) is effective in correcting anemia hemodialysis, peritoneal dialysis, and predialysis patients. Limited studies patients with failing renal allografts suggest a similar efficacy but provide little information concerning benefits, dose requirements, or adverse events. This study examined these considerations group of 40 (18 men; 22 women) aged 40.3 +/- 13.8 yr stable, chronic allograft failure. All had hemoglobin < 95 g/L serum creatinine > 250 mumol/L...
Objectives Since February 2017, an increase of acute hepatitis A (AHA) cases has been notified in North France. We aimed to report clinical and virological features 49 treated three hospitals Lille European Metropolis (LEM). Methods All adult patients for AHA 3 LEM between 20 5 July 2017 were included. Demographic characteristics, exposure risk factors virus (HAV), manifestations concomitant sexually transmitted infections (STI) retrospectively recorded. Results Forty-nine diagnosed among...