A5018221221- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Neurological Complications and Syndromes
- Renal Diseases and Glomerulopathies
- Pharmacological Effects and Toxicity Studies
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Lipoproteins and Cardiovascular Health
- Pregnancy and Medication Impact
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Diabetes Treatment and Management
- Hepatitis B Virus Studies
- Chronic Kidney Disease and Diabetes
- Animal Virus Infections Studies
- Pharmaceutical Economics and Policy
- Influenza Virus Research Studies
- Organ and Tissue Transplantation Research
- Viral-associated cancers and disorders
- Blood Coagulation and Thrombosis Mechanisms
- Polyomavirus and related diseases
Johns Hopkins Medicine
2025
Johns Hopkins University
2025
University of Oxford
2023
University Health Network
2011-2022
Toronto General Hospital
2006-2022
Sandia National Laboratories California
2020
University of Toronto
2008-2019
University of Glasgow
2005-2015
Tufts Medical Center
2011
Brigham and Women's Hospital
2011
Abstract. Dual transplant of marginal kidneys otherwise not considered for single may give access to an expanded pool cadaveric organs without exposing recipients the drawbacks a limited nephron mass supply. This prospective, case-control study compares adverse events and graft outcome in 24 two from donors who were >60 yr old or had diabetes, hypertension, non-nephrotic proteinuria (cases), with that 48 age- gender-matched control subjects received ideal grafts at same center given...
Abstract Ribavirin, a synthetic guanosine analogue, possesses broad spectrum of activity against DNA and RNA viruses. It has been previously shown to attenuate the course fulminant hepatitis in mice produced by murine virus strain 3. We therefore studied effects ribavirin on 3 replication, macrophage production proinflammatory mediators including TNF, IL-1, procoagulant (PCA), fgl2 prothrombinase; Th1/Th2 cytokine production. Although had inhibitory viral replication (<1 log), even at...
Despite the need to expand donor pool, it is unclear what parameters should be used. The value of renal pathology and calculated creatinine clearance (CrCl) in determining recipient outcome was assessed 57 kidney transplants from 34 donors whom pretransplant biopsies were performed because age > or =60, hypertension, and/or vascular disease. We retrospectively compared clinical outcomes these recipients control selected have same baseline demographics but receiving low risk who significantly...
Development of new therapeutic strategies to improve long-term transplant outcomes requires improved understanding the mechanisms by which these complications limit survival.The association acute rejection and new-onset diabetes was determined in first posttransplantation year with failure from any cause, death-censored graft loss, death a functioning 27,707 adult recipients kidney-only transplants, survival at least 1 yr, performed between 1995 2002 United States.In multivariate analyses,...
We conducted a prospective randomized study in which patients with biopsy-confirmed idiopathic membranous nephropathy were assigned to receive either six-month course of prednisone given on alternate days (45 mg per square meter body-surface area; n = 81) or no specific treatment (n 77). The mean duration follow-up was 48 months. Patients the group (median age, 46 years) entered disease 15 months, median creatinine clearance 1.2 ml second 1.73 m2 (range, 0.25 2.6), and rate urinary protein...
Background. The safety, tolerability, and pharmacokinetics of conventional cyclosporine (ConCsA) microemulsion (MeCsA) were compared under conditions normal clinical practice in a prospective, randomized, concentration-controlled, pharmacoepidemiologic study. Methods. Between September 1994 March 1995, 1097 stable renal transplant recipients 14 Canadian centers randomized 2:1 to treatment with MeCsA or ConCsA. Patients commenced on each study drug at dose equal their previous therapy ConCsA,...
HALLORAN, PHILIP F.; APRILE, MARUE A.; FAREWELL, VERN; LUDWIN, DAVID; SMITH, E. KINSAY; TSAI, SHIAN Y.; BEAR, ROBERT COLE, EDWARD H.; FENTON, STANLEY S.; CATTRAN, DANIEL C. Author Information
Delayed graft function (DGF) associates with an increased risk for failure, but its link death (DWGF) is unknown. We used the US Renal Data System to assemble a cohort of all first, adult, deceased-donor kidney transplant recipients from January 1, 1998, through December 31, 2004. In total, 11,542 (23%) 50,246 required at least one dialysis session in first week after transplantation. Compared patients without DGF, DGF were significantly more likely die functioning (relative hazard 1.83 [95%...
Background— Kidney transplant recipients, like other patients with chronic kidney disease, experience excess risk of cardiovascular disease and elevated total homocysteine concentrations. Observational studies suggest increased is a factor for disease. The impact lowering levels in recipients unknown. Methods Results— In double-blind controlled trial, we randomized 4110 stable to multivitamin that included either high dose (n=2056) or low (n=2054) folic acid, vitamin B6, B12 determine...
Benefits of conversion from calcineurin inhibitor (CNI) to mammalian target rapamycin inhibitor-based immunosuppression in long-term kidney transplant patients remain uncertain.ASCERTAIN was a 24-month, open-label, multicenter study. Kidney more than 6 months posttransplant receiving CNI (baseline glomerular filtration rate [GFR] 30-70 mL/min/1.73 m) were randomized everolimus with elimination (n=127) or minimization (n=144), continued unchanged (controls, n=123) assess the effect on...
The COVID-19 pandemic has hit the entire world in an almost unprecedented way. crisis spread rapidly, disease burden and casualties continue to rise, impact of is spreading through developing countries. Social distancing, travel restrictions, intensified testing have improved rate rise new cases some regions; however, it remains unclear when normality will return. Mechanisms remain largely unclear; treatment, if available, mostly supportive. As during times war, challenges coronavirus change...
ABSTRACT. Transplantation offers superior life expectancy and quality of compared with dialysis in young patients end-stage renal failure. However, the initial risks mortality morbidity are high. This study used a decision analysis model to evaluate costs benefits kidney transplantation versus continued for older A analytic comparing cadaveric hemodialysis treatment was developed. The base case considered theoretical cohort aged 65 yr without known comorbidity or contraindications who would...
Renal transplant recipients experience premature cardiovascular disease and death. The association of inflammation, all-cause mortality, events in renal has not been examined a large prospective controlled trial.ALERT was randomized, double-blind, placebo-controlled study the effect fluvastatin on outcomes 2102 recipients. Patients initially randomized to or placebo 5- 6-yr trial were offered open-label 2-yr extension original study. between inflammation markers, high-sensitivity C-reactive...