A5101782352- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Algorithms and Data Compression
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Gene expression and cancer classification
- Genetic and phenotypic traits in livestock
- Nutrition and Health in Aging
- Frailty in Older Adults
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Machine Learning in Bioinformatics
- Cellular Automata and Applications
- T-cell and B-cell Immunology
- Enzyme-mediated dye degradation
- Sustainability and Ecological Systems Analysis
- RNA modifications and cancer
- bioluminescence and chemiluminescence research
- Immunotoxicology and immune responses
- Mobile Health and mHealth Applications
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Head and Neck Anomalies
- Congenital heart defects research
Montreal Heart Institute
2024-2025
Peking University
2023-2025
McGill University
2020-2024
Huazhong Agricultural University
2011-2024
Université de Montréal
2024
Shenzhen Maternity and Child Healthcare Hospital
2024
University of Copenhagen
2023
University of Science and Technology Beijing
2021-2022
Heze Municipal Hospital
2020
Nanjing Tech University
2018
Abstract Currently, diabetic infectious wound treatments remain a significant challenge for regenerative medicine due to the unicity of clinical dressings, which lack systemic multifunctional dressings with high absorbability, customizable shape, rapid self‐healing, guiding tissue regeneration, and restoring physiological functions. Here, DNA hydrogel is conveniently obtained through grafting units polyethyleneimine dynamic cross‐linking doped heating function black phosphorus quantum dots....
Abstract A grade 3 burn is a nonstatic fatal injury, which can lead to complete damage the skin structure, accompanied by series of symptoms such as persistent inflammation, pain, pruritus, ulcer, and peripheral neuropathy. Although primary clinical treatment grafting, it cannot comprehensively solve symptoms. Here, multifunctional DNA hydrogel integrated system conveniently obtained through dynamic cross‐linking unit, polyacrylamide, l ‐ascorbate 2‐phosphate ( ‐A2P) formation dense hydrogen...
Abstract The multifunctionality and sustainability of ecosystems are strongly dependent on their ability to withstand recover from disturbances—that is, ecosystem resilience (ER). However, the dynamics attributes ER remain largely unknown, especially in China, where climatic anthropogenic pressures high. In this study, we evaluated spatiotemporal patterns China 2001 2020 using solar-induced chlorophyll fluorescence. We estimated relative independent importance climate change, CO 2 , factors...
Colocalization analysis is commonly used to assess whether two or more traits share the same genetic signals identified in genome-wide association studies (GWAS), and important for prioritizing targets functional follow-up of GWAS results. Existing colocalization methods can have suboptimal performance when there are multiple causal variants one genomic locus.
To mitigate risks related to human leukocyte antigen (HLA) incompatibility, we assessed whether certain structurally defined HLA targets present in donors but absent from recipients, known as eplet mismatches (EMM), are associated with death-censored graft failure (DCGF).We studied a cohort of 118,313 American 0% panel reactive antibodies (PRA) first kidney transplant recipients (2000 2015) the Scientific Registry Transplant Recipients. Imputed allele-level donor and recipient HLA-A, -B, -C,...
Circular RNAs (circRNAs) are involved in the development of human cancers, including cervical cancer (CC). However, role and mechanism circRNA hsa_circ_0000285 (circ_0000285) CC remain largely unknown.Thirty paired adjacent normal tissue samples were harvested. cell lines SiHa HeLa cultured this study. The expression circ_0000285, miR197-3p ELK1 was detected via qRT-PCR or Western blot. assessed viability, colony formation, apoptosis, cycle, autophagy using MTT, colony-formation assays, flow...
Identifying causal variants from genome-wide association studies (GWAS) is challenging due to widespread linkage disequilibrium (LD) and the possible existence of multiple in same genomic locus. Functional annotations genome may help prioritize that are biologically relevant thus improve fine-mapping GWAS results. Classical methods conducting an exhaustive search variant-level configurations have a high computational cost, especially when underlying genetic architecture LD patterns complex....
Summary Fusarium head blight (FHB) and the presence of mycotoxin deoxynivalenol (DON) pose serious threats to wheat production food safety worldwide. DON, as a virulence factor, is crucial for spread FHB pathogens on plants. However, germplasm resources that are naturally resistant DON DON‐producing inadequate in Here, detoxifying bacteria genes responsible epimerization were used enhance resistance pathogens. We characterized complete pathway molecular basis leading thorough detoxification...
Abstract Background Characterizing genetic effect heterogeneity across subpopulations with different environmental exposures is useful for identifying exposure-specific pathways, understanding biological mechanisms underlying disease and further pinpointing modifiable risk factors prevention management. Classical gene-by-environment interaction (GxE) analysis can be used to characterize heterogeneity. However, it have a high multiple testing burden in the context of genome-wide association...
Abstract Major depressive disorder (MDD) associated genetic variants reside primarily in the non-coding, regulatory genome. Here we investigate genome-wide differences and putative gene-regulatory effects of disease risk-variants by examining chromatin accessibility combined with single-cell gene-expression profiles over 200,000 cells from dorsolateral prefrontal cortex (DLPFC) 84 individuals MDD neurotypical controls. MDD-associated alterations were prominent deep-layer excitatory neurons...
Abstract Summary Mendelian randomization is being utilized to assess causal effects of polygenic exposures, where many genetic instruments are subject horizontal pleiotropy. Existing methods for detecting and correcting pleiotropy have important assumptions that may not be fulfilled. Built upon the core gene hypothesis, we developed MR Corge performing sensitivity analysis randomization. identifies a small number putative more likely affect genes with direct biological role in an exposure...
Circulating proteins influence disease risk and are valuable drug targets. To enhance the discovery of protein-phenotype associations identify potential therapeutic targets across diverse populations, we conducted proteome-phenome-wide Mendelian randomization in three ancestries, followed by comprehensive sensitivity analyses. We tested causal effects up to 2,265 unique on a curated list 355 distinct phenotypes, identifying 726,035 pairs European, 33,078 African, 115,352 East Asian...
Abstract Fine-mapping methods based on summary statistics from genome-wide association studies (GWAS) and linkage disequilibrium (LD) information are widely used to identify potential causal variants. However, LD mismatch between the external reference panel GWAS population is common can lead compromised accuracy of fine-mapping. We developed RSparsePro, a probabilistic graphical model with an efficient variational inference algorithm, perform robust fine-mapping in presence mismatch. In...
Abstract Genetic colocalization analyses are frequently conducted to determine if causal signals at a genetic locus shared between two phenotypes. However, is rarely undertaken the HLA locus, due its complex linkage disequilibrium (LD) and high polymorphism density. This lack of inference method limits our ability translate associations into therapeutic targets. Here we present that uses alleles, instead nucleotide variants, perform traits genes. The method, which call HLA-colocalization,...
Abstract Motivation Colocalization analysis is commonly used to assess whether two or more traits share the same genetic signals identified in genome-wide association studies (GWAS), and important for prioritizing targets functional follow-up of GWAS results. Existing colocalization methods can have suboptimal performance when there are multiple causal variants one genomic locus. Results We propose SharePro extend COLOC framework analysis. Share-Pro integrates linkage disequilibrium (LD)...
The majority of genome-wide association studies (GWAS) loci are not annotated to known genes in the human genome, which renders biological interpretations difficult. Transcriptome-wide (TWAS) associate complex traits with genotype-based prediction gene expression deriving from quantitative loci(eQTL) studies, thus improving interpretability GWAS findings. However, these results can sometimes suffer a high false positive rate, because predicted different may be highly correlated due linkage...