A5038560577- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Cardiac Ischemia and Reperfusion
- Neuropeptides and Animal Physiology
- Vagus Nerve Stimulation Research
- Pharmacological Receptor Mechanisms and Effects
- Pharmacological Effects and Toxicity Studies
- Signaling Pathways in Disease
- Receptor Mechanisms and Signaling
- Galectins and Cancer Biology
- Single-cell and spatial transcriptomics
- Cannabis and Cannabinoid Research
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Neurogenesis and neuroplasticity mechanisms
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Amyotrophic Lateral Sclerosis Research
- Peroxisome Proliferator-Activated Receptors
- Cancer, Stress, Anesthesia, and Immune Response
- Multiple Sclerosis Research Studies
- Sirtuins and Resveratrol in Medicine
McGill University
2020-2024
The University of Sydney
2024
Douglas Mental Health University Institute
2020-2024
Université Laval
2015-2024
University of Groningen
2022
University of Amsterdam
2022
University of Toronto
2019
Mashhad University of Medical Sciences
2019
University of Tehran
2007-2019
Sensorion (France)
2019
While reactive microgliosis is a hallmark of advanced stages amyotrophic lateral sclerosis (ALS), the role microglial cells in events initiating and/or precipitating disease onset largely unknown. Here we provide novel vivo evidence distinct adaptive shift functional phenotypes preclinical superoxide dismutase 1 (SOD1)-mutant-mediated disease. Using mouse model for live imaging activation crossed with SOD1 G93A and G37R models, discovered that preonset phase SOD1-mediated characterized by...
Early-life stress (ELS) leads to increased vulnerability psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated ELS-induced negative health outcomes, but how ELS impacts microglia, the main tissue-resident macrophages of central nervous system, is unknown. Here, we determined effects by limited bedding and nesting material during first week life (postnatal days [P]2-9) on microglial (i) morphology; (ii) hippocampal gene expression; (iii)...
There is a pressing need for research that will lead to the development of new therapeutic approaches treating inflammatory bowel disease (IBD). The aim this study was investigate effects tropisetron, 5-Hydroxytryptamine (5-HT)-3 receptor antagonist with anti-inflammatory properties in model experimental colitis rat.Acetic acid rats used. Colitis induced by intracolonal instillation 4% (v/v) acetic acid. One hour after induction colitis, intraperitoneal (IP) or intrarectal (IR) tropisetron...
Uncontrolled microglial activation may lead to the development of inflammation-induced brain damage. Here, we uncover a ribosome-based mechanism/checkpoint involved in control innate immune response and activation. Using an vivo model system for analysis dynamic translational state ribosomes, with mRNAs as input newly synthesized peptides output, find marked dissociation microglia mRNA protein networks following challenge. Highly upregulated ribosome-associated were not translated, resulting...
The cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark degenerating neurons in amyotrophic lateral sclerosis (ALS) and subsets frontotemporal dementia (FTD). In order to reduce TDP-43 pathology, we generated single-chain (scFv) antibodies against the RNA recognition motif 1 (RRM1) TDP-43, which involved abnormal protein self-aggregation interaction with p65 NF-κB. Virus-mediated delivery into nervous system scFv antibody, named VH7Vk9, reduced microgliosis mouse...
We recently described a novel ribosome-based regulatory mechanism/checkpoint that controls innate immune gene translation and microglial activation in non-sterile inflammation orchestrated by RNA binding protein SRSF3. Here we describe role of SRSF3 the regulation microglia/macrophage phenotypes after experimental stroke. Using model-system for analysis dynamic translational state ribosomes show 24 h stroke highly upregulated mRNAs are not translated resulting marked dissociation mRNA...
Abstract Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form net-like coverings around certain neurons in the brain. PNNs primarily composed chondroitin sulfate (CS) proteoglycans from lectican family consist CS-glycosaminoglycan side chains attached to core protein. CS disaccharides can exist various isoforms with different sulfation patterns. Literature suggests disaccharide patterns influence function as well their labeling. This study was conducted...
Abstract Background Alzheimer's disease ( AD ) is a neurodegenerative disorder featured by deposition of beta‐amyloid (Aβ) plaques in the hippocampus and associated cortices progressive cognitive decline. Tropisetron, selective 5‐ HT 3 receptor antagonist, conventionally used to counteract chemotherapy‐induced emesis. Recent investigations describe antiphlogistic properties for tropisetron. It has been shown that tropisetron protects against rat embolic stroke. We investigated protective...
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme involved in the recycling of nicotinamide to maintain adequate NAD levels inside cells. It has been postulated be pharmacological target, as it overexpressed cancer cells well inflammatory diseases. We describe synthesis and characterization novel class one-digit nanomolar NAMPT inhibitors based on vitro characterization. The most active compound tested, 30c, displayed activity xenograft allograft models, strengthening potential...
Abnormal cytoplasmic mislocalization of transactive response DNA binding protein 43 (TARDBP or TDP-43) in degenerating neurons is a hallmark amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Our previous work suggested that nuclear factor kappa B (NF-κB) may constitute therapeutic target for TDP-43-mediated disease. Here, we investigated the effects root extract Withania somnifera (Ashwagandha), an herbal medicine...
Emerging data implicate nicotinamide phosphoribosyl transferase (NAMPT) in the pathogenesis of cancer and inflammation. NAMPT inhibitors have proven beneficial inflammatory animal models arthritis endotoxic shock as well autoimmune encephalitis. Given role responses spinal cord injury (SCI), effect was examined this setting.We investigated effects inhibitor FK866 an experimental compression model SCI.Twenty-four hr following induction SCI, a significant functional deficit accompanied...