A5055797223- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Proteoglycans and glycosaminoglycans research
- Fibroblast Growth Factor Research
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Neurological Disease Mechanisms and Treatments
- Inflammatory Bowel Disease
- Memory and Neural Mechanisms
- Glaucoma and retinal disorders
- Neurogenesis and neuroplasticity mechanisms
- Glycosylation and Glycoproteins Research
- Tryptophan and brain disorders
McGill University
2023-2024
Douglas Mental Health University Institute
2022-2024
Abstract Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form net-like coverings around certain neurons in the brain. PNNs primarily composed chondroitin sulfate (CS) proteoglycans from lectican family consist CS-glycosaminoglycan side chains attached to core protein. CS disaccharides can exist various isoforms with different sulfation patterns. Literature suggests disaccharide patterns influence function as well their labeling. This study was conducted...
Abstract Microglia, known for their diverse roles in the central nervous system, have recently been recognized involvement degrading extracellular matrix. Perineuronal nets (PNNs), a specialized form of this matrix, are crucial stabilizing neuronal connections and constraining plasticity. Our group reported increased PNN densities ventromedial prefrontal cortex (vmPFC) depressed individuals that died by suicide adulthood after experiencing childhood abuse (DS-CA) compared to matched...
Abstract The central function of the striatum and its dopaminergic (DA) afferents in motor control integration cognitive emotional processes is commonly explained by two striatal efferent pathways characterized projection neurons (SPNs) expressing DA D1 receptors D2 (D1-SPNs D2-SPNs), without regard to SPNs coexpressing both (D1/D2-SPNs). We developed an approach that enables targeting these hybrid demonstrated although are less abundant, they play a major role guiding other main...
Abstract Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form net-like coverings around certain neurons in the brain. PNNs primarily composed chondroitin sulfate (CS) proteoglycans from lectican family consist CS-glycosaminoglycan (CS-GAG) side chains attached to core protein. CS disaccharides can exist various isoforms with different sulfation patterns. Literature suggests disaccharide patterns influence function as well their labeling. This study was conducted...
Microglia, known for their diverse roles in the central nervous system, have recently been recognized involvement degrading extracellular matrix. Perineuronal nets (PNNs), a specialized form of this matrix, are crucial stabilizing neuronal connections and constraining plasticity. Our group reported increased PNN densities ventromedial prefrontal cortex (vmPFC) depressed individuals that died by suicide adulthood after experiencing childhood abuse (DS-CA) compared to matched controls. To...
Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing deficits patients. In a previous study, we showed blocking D2 dopamine receptors (D2R), core action of APD, led to profound reshaping mesohippocampal fibers, synaptic transmission impairments learning memory the mouse hippocampus (HP). However, it is currently unknown how excessive affects HP-related functions, APD would impact HP functions such...
Abstract Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing deficits patients. In a previous study, we showed blocking D2 dopamine receptors (D2R), core action of APD, led to profound reshaping mesohippocampal fibers, synaptic transmission impairments learning memory the mouse hippocampus (HP). However, it is currently unknown how excessive affects HP-related functions, APD would impact HP functions...
Abstract The olfactory bulb (OB), a major structure of the limbic system, has been understudied in human investigations psychopathologies such as depression. To explore more directly molecular features OB depression, global comparative proteome analysis was carried out with post-mortem samples from 11 males having suffered depression and 12 healthy controls. We identified 188 differentially abundant proteins (with adjusted p<0.05) between depressed cases Gene ontology gene enrichment...