A5036446265- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- MicroRNA in disease regulation
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- RNA modifications and cancer
- Neuroendocrine regulation and behavior
- Neurological Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Axon Guidance and Neuronal Signaling
- Amino Acid Enzymes and Metabolism
- Nerve injury and regeneration
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
Douglas Mental Health University Institute
2016-2025
McGill University
2016-2025
Art Research Centre of the Slovak Academy of Sciences
2024
The University of Sydney
2024
Ludwig-Maximilians-Universität München
2024
Douglas College
2014-2023
Yale University
2022
University of Maryland, Baltimore
2022
Université de Tours
2021-2022
University of Toronto
2020-2022
<h3>Context</h3>Our genome adapts to environmental influences, in part through epigenetic mechanisms, including DNA methylation. Variations the quality of early environment are associated with alterations methylation rodents, and recent data suggest similar processes humans response early-life adversity.<h3>Objective</h3>To determine genome-wide induced by trauma.<h3>Design</h3>Genome-wide study promoter individuals severe abuse during childhood.<h3>Patients, Setting, Main Outcome...
Most studies investigating the neurobiology of depression and suicide have focused on serotonergic system. While it seems clear that alterations play a role in pathogenesis these major public health problems, dysfunction additional neurotransmitter systems other molecular may also be implicated. Microarray expression are excellent screening tools to generate hypotheses about processes at play. In this study we investigated brain regions known implicated likely represent valid global...
Microglia can adopt different morphologies, ranging from a highly ramified to an amoeboid-like phenotype. Although morphological properties of microglia have been described in rodents, little is known about their fine features humans. The aim this study was characterize the morphometric human gray and white matter dorsal anterior cingulate cortex (dACC), region implicated behavioral adaptation neuroinflammation. These were compared those murine order gain better appreciation differences...
Significance Thirty to fifty percent of depressed individuals are unresponsive commonly prescribed antidepressant treatments, suggesting that biological mechanisms, such as stress-induced inflammation and blood vessel dysfunction, remain untreated. The blood–brain barrier is the ultimate frontier between brain harmful toxins or inflammatory signals circulating in blood. Depression vulnerability chronic social stress associated with loss this integrity; however, mechanisms involved poorly...
Child abuse has devastating and long-lasting consequences, considerably increasing the lifetime risk of negative mental health outcomes such as depression suicide. Yet neurobiological processes underlying this heightened vulnerability remain poorly understood. The authors investigated hypothesis that epigenetic, transcriptomic, cellular adaptations may occur in anterior cingulate cortex a function child abuse.Postmortem brain samples from human subjects (N=78) rodent model impact early-life...
Abstract Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers using small RNA-sequencing in paired samples from MDD enrolled large, randomized placebo-controlled trial duloxetine collected before 8 weeks treatment. Our results revealed differential expression miR-146a-5p,...
Blood–brain barrier (BBB) alterations contribute to stress vulnerability and the development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unclear. Here we report that high expression astrocytic cannabinoid receptor 1 (CB1) in nucleus accumbens (NAc) shell, particularly end-feet ensheathing blood vessels, is associated with during chronic social adult male mice. Viral-mediated overexpression Cnr1 astrocytes NAc shell results baseline anxiolytic...
Objective Gene expression changes have been reported in the brains of suicide completers. More recently, differences promoter DNA methylation between completers and comparison subjects specific genes associated with these gene patterns, implicating alterations as a plausible component pathophysiology suicide. The authors used genome-wide approach to investigate extent Method Promoter was profiled using methylated immunoprecipitation (MeDIP) followed by microarray hybridization hippocampal...
Abstract Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as well several debilitating central nervous system (CNS) disorders. In order to fully elucidate the diverse of nicotinic CNS function and dysfunction, a detailed knowledge their cellular subcellular localizations is essential. To date, methods precisely localize have predominantly relied on use anti‐receptor subunit antibodies. Although data obtained by immunohistology immunoblotting are...
Abstract Background Schizophrenia is a severe neuropsychiatric disorder that hypothesized to result from disturbances in early brain development. There mounting evidence support role for developmentally regulated epigenetic variation the molecular etiology of disorder. Here, we describe systematic study schizophrenia-associated methylomic adult and its relationship changes DNA methylation across human fetal Results We profile matched prefrontal cortex cerebellum tissue schizophrenia patients...