A5035373559- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Child Nutrition and Feeding Issues
- Family and Disability Support Research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Child and Adolescent Psychosocial and Emotional Development
- Cannabis and Cannabinoid Research
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Bone health and treatments
- Prenatal Substance Exposure Effects
- BRCA gene mutations in cancer
- Medical Imaging and Pathology Studies
- Bipolar Disorder and Treatment
- Water Treatment and Disinfection
- Genomics and Chromatin Dynamics
- Nutrition, Genetics, and Disease
- Polyamine Metabolism and Applications
Université Laval
2015-2025
Centres Intégré Universitaires de Santé et de Services Sociaux
2016-2023
Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale
2016-2023
Occupational Cancer Research Centre
2023
Institut Universitaire en Santé Mentale de Québec
2012-2017
Johns Hopkins University
2009-2015
National Human Genome Research Institute
2014
National Institutes of Health
2014
Centre de Médecine Préventive
2012
University of Lethbridge
2004-2005
<h3>Context</h3>Our genome adapts to environmental influences, in part through epigenetic mechanisms, including DNA methylation. Variations the quality of early environment are associated with alterations methylation rodents, and recent data suggest similar processes humans response early-life adversity.<h3>Objective</h3>To determine genome-wide induced by trauma.<h3>Design</h3>Genome-wide study promoter individuals severe abuse during childhood.<h3>Patients, Setting, Main Outcome...
Abstract There has been a great interest and few successes in the identification of complex disease susceptibility genes recent years. Association studies, where large number single‐nucleotide polymorphisms (SNPs) are typed sample cases controls to determine which associated with specific disease, provide powerful approach for gene mapping. Genes those studies may contain numbers SNPs that classical statistical methods cannot handle simultaneously without requiring prohibitively sizes. By...
It is unclear whether the association between impulsive-aggressive behaviours and suicide exists across different ages.Via psychological autopsy, we examined a total of 645 subjects aged 11-87 years who died by suicide. Proxy-based interviews were conducted using SCID-I & SCID-II or K-SADS series behavioural personality-trait assessments. Secondarily, 246 living controls similarly assessed.Higher levels impulsivity, lifetime history aggression, novelty seeking associated with younger age...
Genome wide array studies have reported limited success in identifying genetic markers conferring risk for suicidal behavior (SB). This may be attributable to study designs with primary outcome other than SB. We performed a GWAS on suicides and cases history of nonfatal suicide attempts compared psychiatric controls healthy volunteers. A consortium USA, Canadian German teams assembled two groups (suicide attempters suicides, N = 577) non‐attempter (N 1,233). Logistic regression was used test...
A dozen genes/regions have been confirmed as genetic risk factors for oral clefts in human association and linkage studies, animal models argue even more genes may be involved. Genomic sequencing studies should identify specific causal variants reveal additional influencing to clefts, which a complex heterogeneous etiology. We conducted whole exome (WES) study search potentially using affected relatives drawn from multiplex cleft families. Two or three second, third, higher degree 55...
While the genetic and environmental contributions to developmental dyslexia ( DD ) have been studied extensively, effects of identified risk susceptibility specified hazardous factors usually investigated separately. We assessed potential gene‐by‐environment GxE interactions on ‐related reading, spelling memory phenotypes. The presence were for DYX1C1 , DCDC2 KIAA0319 ROBO1 genes, seven moderators in 165 nuclear families which at least one member had by implementing a general test...
Since the beginning of COVID-19 pandemic, many countries, including Canada, have adopted unprecedented physical distancing measures such as closure schools and non-essential businesses, restrictions on gatherings household visits. We described time trends in social contacts for pre-pandemic pandemic periods Quebec, Canada.CONNECT is a population-based study conducted shortly before (2018/2019) during (April 2020 - February 2021), using same methodology both periods. recruited participants by...
Abstract Altered stress reactivity is considered to be a risk factor for both major depressive disorder and suicidal behavior. The authors have sought expand their previous findings implicating altered expression of spermidine/spermine N 1 ‐acetyltransferase (SAT1), the rate‐limiting enzyme involved in catabolism polyamines spermidine spermine polyamine response (PSR), across multiple brain regions between control individuals depressed who died by suicide. Microarray probesets annotated SAT1...
In recent years, gene expression, genetic association, and metabolic studies have implicated the polyamine system in psychiatric conditions, including suicide. Given extensive regulation of genes involved metabolism, as well their interconnections with metabolism other amino acids, we were interested further investigating expression polyamine-related across brain order to obtain a more comprehensive view dysregulation this To end, examined related 22 regions sample 29 mood-disordered suicide...
Little attention has been paid to neurotoxicants on the risk of dementia. Exposure known such as polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is suspected have adverse cognitive effects in older populations.To assess whether plasma concentrations PCBs OC are associated with decline, Alzheimer's disease (AD) all-cause dementia Canadian population.Analyses were based data from Study Health Aging, a 3-phase, 10-year population-based study individuals aged 65+ years....
Abstract Random Forest is a prediction technique based on growing trees bootstrap samples of data, in conjunction with random selection explanatory variables to define the best split at each node. In case quantitative outcome, tree predictor takes numerical value. We applied first replicate Genetic Analysis Workshop 13 simulated data set, sibling pairs as our units analysis and identity by descent (IBD) selected loci variables. With knowledge true model, we performed two sets analyses three...
Abstract Disease progression in prospective clinical and epidemiological studies is often conceptualized terms of transitions between disease states. Analysis data from such can be complicated by a number factors, including the presence individuals various prevalent states with unknown prior history, interval censored observations state misclassified measurements We present an approach where are modelled as hidden continuous time Markov model using imperfect observations. Covariate effects...
The polyamine system has been implicated in a number of psychiatric conditions, which display both alterations levels and altered expression genes related to metabolism. Studies have identified associations between genetic variants spermidine/spermine N1-acetyltransferase (SAT1) anxiety suicide, several polymorphisms appear play important roles determining gene expression.We genotyped 63 polymorphisms, spread across four polyaminergic (SAT1, spermine synthase (SMS), oxidase (SMOX), ornithine...
Abstract Motivation: Family-based designs are regaining popularity for genomic sequencing studies because they provide a way to test cosegregation with disease of variants that too rare in the population be tested individually conventional case–control study. Results: Where only few affected subjects per family sequenced, probability any variant would shared by all relatives—given it occurred one member—provides evidence against null hypothesis complete absence linkage and association. A P...
Suicide and suicide attempts are complex behaviors that result from the interaction of different factors, including genetic variants increase predisposition to suicidal behaviors. Copy number variations (CNVs) deletions or duplications a segment DNA usually larger than one kilobase. These structural changes, although quite rare, have been associated with liability mental disorders, such as autism, schizophrenia, bipolar disorder. No genome-wide level studies published investigating potential...
Genetically high-risk children carry indicators of brain dysfunctions that adult patients with schizophrenia or bipolar disorder display. The accumulation risk would have a higher predictive value later transition to psychosis mood than each individual indicator. Since more 50% report having been exposed childhood trauma, we investigated whether exposure trauma during was associated the early in youths at genetic risk.
Founder events influenced the genetic diversity within Quebec province, increasing frequency of certain rare pathogenic variants in regional populations. Some regions such as Beauce remain understudied despite evidence a founder effect. Leveraging extensive genealogical data, we found specific structure emerging following initial settlement, with gradual increase inbreeding and kinship coefficients low ancestors diversity. Profiting from distinctiveness region, identified 28 higher carrier...
ABSTRACT A large proportion of genetic variations involved in complex diseases are rare and located within noncoding regions, making the interpretation underlying biological mechanisms a daunting task. Although technical methodological progress has been made to annotate genome, current disease‐rare‐variant association tests incorporating such annotations suffer from two major limitations. First, they generally restricted case−control designs unrelated individuals, which often require tens or...
Abstract Objective: Inflammatory markers may be associated with breast cancer risk. We assessed the association between expression levels of proinflammatory (interleukin 6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase 2, leptin, serum amyloid A1, interleukin 8, and signal transducer activator transcription 3) anti-inflammatory (transforming growth factor-β, 10, lactoferrin) in normal tissue mammographic density, a strong risk indicator, among 163 patients. Methods: The...
Abstract Following our report of a linkage at 12q24 with phenotype obesity under antipsychotics, we tested the pro‐melanin‐concentrating hormone (PMCH) candidate gene for possible association in humans body mass index (BMI; kg/m 2 ) unrelated schizophrenic patients (SZ) receiving antipsychotics (N = 300) and controls (CTL; N 150). Subjects were classified obese (OB) (BMI ≥ 30 ), overweight (25 ≤ BMI < normal weight 25 groups. Single nucleotide polymorphisms (SNP) rs7973796 rs11111201,...