A5032968625- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- Treatment of Major Depression
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Diet, Metabolism, and Disease
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Functional Brain Connectivity Studies
- Adipose Tissue and Metabolism
- Substance Abuse Treatment and Outcomes
- Opioid Use Disorder Treatment
- Neural and Behavioral Psychology Studies
- Fatty Acid Research and Health
- Identity, Memory, and Therapy
- Pain Management and Opioid Use
University of Guelph
2015-2025
University of Toronto
2025
University of Oklahoma
2024
Concordia University
2001-2002
McGill University
1996-2000
Abstract Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers using small RNA-sequencing in paired samples from MDD enrolled large, randomized placebo-controlled trial duloxetine collected before 8 weeks treatment. Our results revealed differential expression miR-146a-5p,...
Experiments in our laboratory have shown that central noradrenergic (NA) activation plays a major role stress-induced reinstatement of drug seeking rats. In the present experiments, we investigated effects blockade β-NA adrenoceptors bed nucleus stria terminalis (BNST) and region amygdala (CeA) on footshock- cocaine-induced reinstatement. Rats were trained to self-administer cocaine (0.5 mg/kg, i.v.) for 9 d and, after 5–7 drug-free period, given extinction sessions followed by test...
Major Depressive Disorder (MDD) is among the most prevalent and disabling medical conditions worldwide. Identification of clinical biological markers ("biomarkers") treatment response could personalize decisions lead to better outcomes. This paper describes aims, design, methods a discovery study biomarkers in antidepressant response, conducted by Canadian Biomarker Integration Network Depression (CAN-BIND). The CAN-BIND research program investigates identifies that help predict outcomes...
To report the symptomatic and functional outcomes in patients with major depressive disorder (MDD) during a 2-phase treatment trial to estimate value of early improvement after 2 weeks predicting clinical response escitalopram subsequently adjunctive aripiprazole.Participants MDD (N = 211) identified Montgomery-Asberg Depression Rating Scale (MADRS) confirmed Mini-International Neuropsychiatric Interview were recruited from 6 outpatient centers across Canada (August 2013 through December...
Blast injury to brain, a hundred-year old problem with poorly characterized neuropathology, has resurfaced as health concern in recent deployments Iraq and Afghanistan. To characterize the neuropathology of blast injury, we examined brains veterans for presence amyloid precursor protein (APP)-positive axonal swellings typical diffuse (DAI) compared them healthy controls well opiate overdose, anoxic-ischemic encephalopathy, non-blast TBI (falls motor vehicle crashes).In cases history, found...
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Abstract Major depressive disorder (MDD) is primarily treated with antidepressants, yet many patients fail to respond adequately, and identifying antidepressant response biomarkers thus of clinical significance. Some hypothesis-driven investigations epigenetic markers for treatment have been previously made, but genome-wide approaches remain unexplored. Healthy participants ( n = 112) MDD 211) between 18–60 years old were recruited an 8-week trial escitalopram treatment. Responders...
Abstract Rats with extensive lesions to the mammillary body region, hippocampus, or rats which had received a control operation were trained postoperatively on two visuo‐spatial conditional associative learning tasks in they learn associate spatial cues particular visual/auditory stimuli. The animals subsequently working memory task, eight‐arm radial maze. region able acquire at rate comparable that of operated animals, whereas those hippocampal not. By contrast, lesion hippocampus...