A5023923022- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Digital Mental Health Interventions
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pharmacogenetics and Drug Metabolism
- Adolescent and Pediatric Healthcare
- Primary Care and Health Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Maternal Mental Health During Pregnancy and Postpartum
- Workplace Health and Well-being
- Innovations in Medical Education
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Healthcare professionals’ stress and burnout
- Employment and Welfare Studies
- Bariatric Surgery and Outcomes
- Eating Disorders and Behaviors
University of Michigan
2016-2025
Michigan Medicine
2018-2024
McGill University
1984-2024
The Christie NHS Foundation Trust
2024
University Hospitals Birmingham NHS Foundation Trust
2024
Queen Elizabeth Hospital
2024
Michigan United
2021-2023
University of Virginia
2023
Nathan Kline Institute for Psychiatric Research
2023
Sage Therapeutics (United States)
2023
The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines bipolar disorder in 2005, along with international commentaries subsequent updates 2007, 2009, 2013. last two were collaboration the International Society Bipolar Disorders (ISBD). These 2018 CANMAT ISBD Treatment Guidelines represent significant advances field since full edition was including to diagnosis management as well new research into pharmacological psychological treatments. have...
Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O’Donovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran Young LT, Milev R, Bond DJ, Frey BN, Goldstein BI, Lafer B, Birmaher Ha K, Nolen WA, Berk M. Canadian Network for Mood and Anxiety Treatments (CANMAT) International Society Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines the management patients with bipolar disorder: 2013. Disord 2012: 00: 000–000. © 2012 John Wiley & Sons A/S.Published by...
The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines the management of bipolar disorder in 2005, with a 2007 update. This second update, conjunction International Society Bipolar Disorders (ISBD), reviews new evidence is designed to be used previous publications. recommendations acute mania remain mostly unchanged. Lithium, valproate, several atypical antipsychotics continue first‐line treatments mania. Tamoxifen now suggested as third‐line augmentation option....
Current prescribing practices for major depressive disorder (MDD) produce limited treatment success. Although pharmacogenomics may improve outcomes by identifying genetically inappropriate medications, studies to date were in scope. Outpatients (N = 1167) diagnosed with MDD and a patient- or clinician-reported inadequate response at least one antidepressant enrolled the Genomics Used Improve DEpression Decisions (GUIDED) trial - rater- patient-blind randomized controlled trial. Patients as...
Abstract Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers using small RNA-sequencing in paired samples from MDD enrolled large, randomized placebo-controlled trial duloxetine collected before 8 weeks treatment. Our results revealed differential expression miR-146a-5p,...
Background The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines the management of major depressive disorder (MDD) in 2016. Owing to advances field, an update was needed incorporate new evidence provide revised recommendations assessment MDD adults. Methods CANMAT convened a editorial group comprised academic clinicians patient partners. A systematic literature review conducted, focusing on reviews meta-analyses since 2016 guidelines....
This study assessed the efficacy and safety of a 14-day treatment course once-daily zuranolone 50 mg, an investigational oral positive allosteric modulator γ-aminobutyric acid type A (GABA
Objective: Bipolar disorder is associated with a high frequency of both completed suicides and suicide attempts. The primary aim this study was to identify clinical predictors attempts in subjects bipolar disorder. Methods: We studied 336 diagnosis I, II, or schizoaffective (bipolar type). Structured Clinical Interview for DSM‐IV (SCID‐I) administered subsequently two expert psychiatrists established diagnosis. Predictors were examined attempters non‐attempters. Results: lifetime rate the...
In 2005, the Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines management of bipolar disorder. This update reviews new evidence since previous publication incorporates recommendations based on most current treatment various phases It is designed to be used in conjunction with 2005 CANMAT Guidelines. The acute mania remain mostly unchanged. Lithium, valproate several atypical antipsychotics continue recommended as first‐line treatments mania. For depression, data...
Objective:Numerous studies have linked childhood trauma with depressive symptoms over the life span. However, it is not known whether particular neurovegetative symptom clusters or affective disorders are more closely early abuse than others. In a large community sample from Ontario, authors examined history of physical sexual in was associated depression, mania, both.Method:The World Health Organization Composite International Diagnostic Interview used to assess 8,116 individuals aged 15–64...
Psychosocial research in bipolar disorder (BD) has not yet assessed the relative benefits of a short course psychoeducation (PE), compared with longer cognitive-behavioural therapy (CBT) containing psychoeducational principles. This pilot study evaluated efficacy and added benefit adding CBT to standard brief PE, as maintenance for BD.Seventy-nine consenting adult men women BD on stable medication regimens, who were full or partial remission from an index episode (BD I = 52; II 27),...
Article Abstract Objective: Bipolar disorder is insufficiently controlled by medication, so several adjunctive psychosocial interventions have been tested. Few studies compared these treatments, all of which are lengthy, expensive, and difficult to disseminate. We the relative effectiveness a brief psychoeducation group intervention more comprehensive longer individual cognitive-behavioral therapy intervention, measuring longitudinal outcome in mood burden bipolar disorder. Method: This...