A5024208397- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Electrolyte and hormonal disorders
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Adolescent and Pediatric Healthcare
- Ion channel regulation and function
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Phosphodiesterase function and regulation
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Genetic Syndromes and Imprinting
- Mental Health Research Topics
- Neurogenesis and neuroplasticity mechanisms
- Endoplasmic Reticulum Stress and Disease
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Family Support in Illness
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Adenosine and Purinergic Signaling
University of Toronto
2015-2025
Centre for Addiction and Mental Health
2011-2025
New College
2023
Université de Montréal
2023
Family Research Institute
2023
Canada Research Chairs
2015-2016
Health Sciences Centre
2015
Sunnybrook Health Science Centre
2015
University of British Columbia
2007-2013
Dalhousie University
2012
Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O’Donovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran Young LT, Milev R, Bond DJ, Frey BN, Goldstein BI, Lafer B, Birmaher Ha K, Nolen WA, Berk M. Canadian Network for Mood and Anxiety Treatments (CANMAT) International Society Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines the management patients with bipolar disorder: 2013. Disord 2012: 00: 000–000. © 2012 John Wiley & Sons A/S.Published by...
Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology of bipolar disorder (BD), major depressive (MDD), and schizophrenia (SCZ). Glutathione (GSH) is free radical scavenger in brain. Diminished GSH levels elevate cellular vulnerability towards stress; characterized by accumulating reactive oxygen species. The aim this study was to determine if mood disorders SCZ are associated with abnormal its functionally related enzymes. Post-mortem prefrontal cortex...
Accumulating evidence suggests that mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of bipolar disorder schizophrenia. It remains unclear whether dysfunction, specifically complex I impairment, is associated with increased damage and, if so, this relationship specific disorder.To evaluate decreased levels electron transport chain subunit NDUFS7 are activity proteins in prefrontal cortex patients disorder, schizophrenia, or major depressive disorder.Postmortem...
Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels cytokines are potential candidates. aim of this study was to examine both cytokine BDNF their relationship BD patients the early late stages disorder. We measured serum BDNF, TNF-α, IL-6 IL-10 total 60 we...
Background: Recent studies indicate the presence of mitochondrial dysfunction in brains subjects with bipolar disorder (BD). Because electron transport chain is a major source for production reactive oxygen species that cause oxidative stress, we sought to determine present study if BD associated stress. Methods: Postmortem anterior cingulate brain sections from BD, depressive (MDD), or schizophrenia, and nonpsychiatric, non‐neurologic comparison controls were generously provided by Stanley...
Chronic restraint stress, psychosocial as well systemic or oral administration of the stress-hormone corticosterone induces a morphological reorganization in rat hippocampus, which adrenal steroids and excitatory amino acids mediate reversible remodeling apical dendrites on CA3 pyramidal cell neurons hippocampus. This stress-induced neuronal is accompanied also by behavioral changes, some can be prevented with selective antidepressant anticonvulsive drug treatments. Lithium an effective...
Abstract Previously, we found decreased mitochondrial complex I subunits levels and increased protein oxidation nitration in postmortem prefrontal cortex ( PFC ) from patients with bipolar disorder BD schizophrenia SCZ ). The objectives of this study were to replicate our findings an independent sample subjects , examine more specifically oxidative nitrosative damage synaptosomal proteins lipid peroxidation myelin. We isolated mitochondria, synaptosomes, myelin using a percoll gradient...
Article Abstract Objective: Bipolar disorder is insufficiently controlled by medication, so several adjunctive psychosocial interventions have been tested. Few studies compared these treatments, all of which are lengthy, expensive, and difficult to disseminate. We the relative effectiveness a brief psychoeducation group intervention more comprehensive longer individual cognitive-behavioral therapy intervention, measuring longitudinal outcome in mood burden bipolar disorder. Method: This...
Background Neuroimaging studies have demonstrated an association between lithium (Li) treatment and brain structure in human subjects. A crucial unresolved question is whether this reflects direct neurochemical effects of Li or indirect secondary to prevention episodes bipolar disorder (BD). Method To address knowledge gap, we compared manually traced hippocampal volumes 37 BD patients with at least 2 years (Li group), 19 <3 months lifetime exposure over ago (non-Li group) 50 healthy...
Hajek T, Cullis J, Novak Kopecek M, Höschl C, Blagdon R, O’Donovan Bauer Young L MacQueen G, Alda M. Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment. Bipolar Disord 2012: 14: 261–270. © 2012 The Authors. Journal compilation John Wiley & Sons A/S. Objective: volume decrease associated with is among the most replicated findings unipolar depression. absence hippocampal changes studies individuals disorder (BD) may reflect neuroprotective...