A5101846707- Vascular Malformations and Hemangiomas
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Tumors and Oncological Cases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Thermochemical Biomass Conversion Processes
- Cancer therapeutics and mechanisms
- Cardiovascular Function and Risk Factors
- Sulfur Compounds in Biology
- Cancer Immunotherapy and Biomarkers
- Cardiac pacing and defibrillation studies
- Renal and related cancers
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Cerebrospinal fluid and hydrocephalus
- Cardiac Ischemia and Reperfusion
- Cancer-related molecular mechanisms research
- Shoulder Injury and Treatment
- Teratomas and Epidermoid Cysts
- Autophagy in Disease and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
Gansu Provincial Hospital
2019-2024
Xi'an Medical University
2018-2024
Shenyang Institute of Engineering
2023-2024
Donghua University
2022-2024
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
2023-2024
Inner Mongolia Medical University
2024
National Clinical Research
2024
Children's Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Second Affiliated Hospital of Jilin University
2024
<h3>Background:</h3> Regeneration of the myocardium and improved ventricular function have been demonstrated in patients with acute myocardial infarction (MI) treated by intracoronary delivery autologous bone marrow mononuclear cells (BMC) a few days after successful reperfusion percutaneous coronary intervention (PCI); however, effects cell infusion chronic MI are still unknown. <h3>Aims:</h3> To investigate whether BMC into infarct-related artery healed could lead to improvement left (LV)...
Abstract Silicosis is a common occupational disease and represents significant contributor to respiratory morbidity mortality worldwide. Lipid-laden macrophages, or foam cells, are observed in the lungs of patients with silicosis but mechanisms mediating their formation remain poorly understood. In this study, we sought elucidate by which silica promotes cell lung, determine whether uptake lipids alone sufficient drive TGF-β production alveolar macrophages. Consistent previous reports, found...
Three-dimensional (3D) printing is emerging as an innovative technology, which widely used in cardiovascular disease at bench and bedside. During the last decade, with development of 3D industry, many printed models have been clinic, because it can provide advantage haptic feedback, direct manipulation, enhanced doctors' understanding anatomy underlying pathologies. In addition to preparation models, technology also shows great application potential regenerative medicine has advantages...
Silicosis is a refractory disease. Previous studies indicate that damaged alveolar epithelial cells act as driver in pulmonary fibrosis. Our results show acquire the mesenchymal phenotype are associated with pathogenesis of silicosis. c-Src kinase, non-receptor tyrosine has been shown to be positive regulator organ fibrosis, but specific mechanisms remain unclear and rarely researched The activated Phosphatidylinositol-3 kinases/AKT(PI3K/AKT) pathway promotes We aimed determine whether...
This study aimed to elucidate the effects of Qingrehuoxue Formula (QRHXF) on NSCLC and its underlying mechanisms.Nude mouse model subcutaneous tumors was established.QRHXF erastin were administered orally intraperitoneally, respectively.Mice's body weight tumor volumes measured.The QRHXF epithelial-mesenchymal transition (EMT), tumor-associated angiogenesis matrix metalloproteinases (MMPs) assessed.Importantly, we also analysed anti-NSCLC form aspect ferroptosis apoptosis investigate...
The aim of this study was to examine the effect ACS14, a hydrogen sulfide (H(2)S)-releasing derivative aspirin (Asp), on Asp-induced gastric injury. Gastric hemorrhagic lesions were induced by intragastric administration Asp (200 mg/kg, suspended in 0.5% carboxymethyl cellulose solutions) volume 1 ml/100 g body weight. ACS14 (1, 5 or 10 mg/kg) given 30 min before administration. total area erosions, H(2)S concentration and oxidative stress tissues measured three hours after Asp. Treatment...
Hydrogen sulfide (H2S) is a gaseous signaling molecule, which plays critical role in number of physiological and pathological progresses. In order to determine the effect endogenous H2S on gastric ischemia-reperfusion (GI-R), we evaluated mucosal damage rats intraperitoneally injected with DL-propargylglycine (PAG, 50 mg/kg/day) or L-cysteine (L-cys, for 7 days before GI-R. GI-R injury was achieved by clamping celiac artery 30 min, followed reperfusion 60 min. Gastric macroscopically...
Abstract Background Inflammation-induced dysfunction of hepatic stellate cells (HSCs) is involved in schistosomiasis-associated liver fibrosis, and soluble egg antigen (SEA) a crucial pathogen-associated molecular pattern associated with injury schistosomiasis. In addition, numerous studies have shown that caspase-1-mediated pyroptosis participates the development multiple inflammation-related diseases. However, whether pyroptotic cell death HSCs SEA-mediated damage not well understood....
We aimed to investigate the expression of EGFR and autophagy-related markers Beclin1 LC3 in cervical cancer.Beclin1, LC3, were analyzed 80 samples squamous cell carcinoma (SCC), 40 high-grade intraepithelial neoplasia (CIN), normal tissues by immunohistochemistry. The protein rates with χ (2) Fisher's exact tests. Differences overall survival (OS) determined using Kaplan-Meier method log-rank tests.Cervical cancer, CIN, epithelial cells expressed 26.2%, 77.5%, 82.5% patients, respectively,...
Hypoxia-inducible factor 2α (HIF2α) plays critical roles in cancer progression. Although the mechanisms of HIF2α translation and degradation have been well studied, mechanism for regulation at transcriptional level is still not fully understood. Here, we present evidence that DNA methylation promoter contributes to transcription EPAS1 coding HIF2α. Methylated CpG binding protein 3 (MBD3) intricate regulatory mechanism. We showed MBD3 bound breast cells amplified through demethylating located...
Abstract Background Small-diameter vascular grafts have become the focus of attention in tissue engineering. Thrombosis and aneurysmal dilatation are two major complications loss access after surgery. Therefore, we focused on fabricating 3D printed electrospun loaded with tetramethylpyrazine (TMP) to overcome these limitations. Methods Based electrospinning printing, 3D-printed TMP were fabricated. The inner layer graft was composed poly(L-lactic-co-caprolactone) (PLCL) nanofibers outer...
<b>Background</b> The thoracoacromial artery perforator (TAAP) flap used in its pedicle or the free microvascular variant is an emerging for use as a reconstructive option head and neck region. <b>Patients Methods</b> Between 2006 2013, 17 patients with mean age of 34 years (range, 17–59 years) underwent TAAP procedure reconstruction postoncologic posttraumatic defects. <b>Results</b> was to reconstruct (<i>n</i> = 5) hypopharyngeal defects 5); resurface lower hemiface 4), tongue 1),...