A5102020355- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Probiotics and Fermented Foods
- Aortic aneurysm repair treatments
- Infant Nutrition and Health
- Extracellular vesicles in disease
- Osteoarthritis Treatment and Mechanisms
- Inflammatory Bowel Disease
- Nitric Oxide and Endothelin Effects
- Genetics, Aging, and Longevity in Model Organisms
- Congenital heart defects research
- CRISPR and Genetic Engineering
- Nanoparticle-Based Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Circular RNAs in diseases
- Silk-based biomaterials and applications
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Skin Protection and Aging
- Infectious Aortic and Vascular Conditions
- Periodontal Regeneration and Treatments
- Cancer-related gene regulation
- Sulfur Compounds in Biology
Shanghai Children's Medical Center
2009-2025
Shanghai Jiao Tong University
2008-2025
University of Science and Technology of China
2014
Renji Hospital
2008
Cartilage engineering strategies using mesenchymal stem cells (MSCs) could provide preferable solutions to resolve long-segment tracheal defects. However, the drawbacks of widely used chondrogenic protocols containing TGF-β3, such as inefficiency and unstable cellular phenotype, are problematic. In our research, optimize differentiation human umbilical cord MSCs (hUCMSCs), kartogenin (KGN) preconditioning was performed prior TGF-β3 induction. hUCMSCs were preconditioned with 1 µM KGN for 3...
Pericardial barrier destruction, inflammatory cell infiltration, and fibrous tissue hyperplasia, trigger adhesions after cardiac surgery. There are few anti-adhesion materials that both functional sutureable for pericardial reconstruction. Besides, a studies have reported on the mechanism of preventing adhesion. Herein, membrane with sutureability was developed via modified electrospinning method. It composed poly(l-lactide-co-caprolactone) (PLCL) nanofibers, poly(vinyl alcohol) (PVA)...
Abstract Small RNAs recognize, bind, and regulate other complementary cellular RNAs. The introduction of small to eukaryotic cells frequently results in unintended silencing related, but not identical, RNAs: a process termed off-target gene silencing. Off-target is one the major concerns during application RNA-based technologies for discovery treatment human disease. commonly thought be due inherent biochemical limitations RNAi machinery. Here we show that following exogenous sources...
Coronary artery bypass grafting often requires autologous veins as alternatives. The limited source and problem of over-expansion are major obstacles for vein grafts, which could be solved by small-diameter artificial vascular graft. However, their clinical application is thrombosis restenosis caused incomplete endothelialization abnormal smooth muscle cells (SMCs) proliferation. Nitric oxide (NO) hydrogen sulfide (H2S) crucial signaling molecules in the cardiovascular system, known to...
Abstract Background Small-diameter vascular grafts have become the focus of attention in tissue engineering. Thrombosis and aneurysmal dilatation are two major complications loss access after surgery. Therefore, we focused on fabricating 3D printed electrospun loaded with tetramethylpyrazine (TMP) to overcome these limitations. Methods Based electrospinning printing, 3D-printed TMP were fabricated. The inner layer graft was composed poly(L-lactic-co-caprolactone) (PLCL) nanofibers outer...