A5030654117- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Nuclear Physics and Applications
- Boron Compounds in Chemistry
- Quantum Computing Algorithms and Architecture
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Gene expression and cancer classification
- Liver physiology and pathology
- Pain Management and Placebo Effect
- Transcranial Magnetic Stimulation Studies
- AI in cancer detection
- Brain Metastases and Treatment
- Bioinformatics and Genomic Networks
- Algorithms and Data Compression
- Carcinogens and Genotoxicity Assessment
- Neurological disorders and treatments
- Digital Mental Health Interventions
- Ultrasound and Hyperthermia Applications
- Management of metastatic bone disease
Augusta University
2021-2024
Queen's University
2013-2024
University of California, San Diego
2023-2024
Quantum Group (United States)
2023
Verasci (United States)
2022
University of California, Los Angeles
2022
Janssen (United States)
2022
Boehringer Ingelheim (Germany)
2022
Neurocrine Biosciences (United States)
2022
Newron Pharmaceuticals (United States)
2022
The epithelial to mesenchymal transition (EMT) is a molecular process through which an cell undergoes transdifferentiation into phenotype. role of EMT in embryogenesis well-characterized and increasing evidence suggests that elements the may be important other processes, including metastasis drug resistance various different cancers.Agilent 4 × 44 K whole human genome arrays selected reaction monitoring mass spectrometry were used investigate mRNA protein expression A2780 cisplatin sensitive...
Depression is a heterogeneous mental illness. Neurostimulation treatments, by targeting specific nodes within the brain's emotion-regulation network, may be useful both as therapies and probes for identifying clinically relevant depression subtypes.Here, we applied 20 sessions of magnetic resonance imaging-guided repetitive transcranial stimulation (rTMS) to dorsomedial prefrontal cortex in 47 unipolar or bipolar patients with medication-resistant major depressive episode.Treatment response...
Despite its high toll on society, there has been little recent improvement in treatment efficacy for major depressive disorder (MDD). The identification of biological markers successful response may allow more personalized and effective treatment. Here we investigate whether resting-state functional connectivity predicted to with repetitive transcranial magnetic stimulation (rTMS) dorsomedial prefrontal cortex (dmPFC). Twenty-five individuals treatment-refractory MDD underwent a 4-week...
Major Depressive Disorder (MDD) is among the most prevalent and disabling medical conditions worldwide. Identification of clinical biological markers ("biomarkers") treatment response could personalize decisions lead to better outcomes. This paper describes aims, design, methods a discovery study biomarkers in antidepressant response, conducted by Canadian Biomarker Integration Network Depression (CAN-BIND). The CAN-BIND research program investigates identifies that help predict outcomes...
<h3>Background</h3> We report a study of machine learning applied to the phenotyping psychiatric diagnosis for research recruitment in youth depression, conducted with 861 labelled electronic medical records (EMRs) documents. A model was built that could accurately identify individuals who were suitable candidates on depression. <h3>Objective</h3> Our objective meet inclusion criteria as well unsuitable patients would require exclusion. <h3>Methods</h3> methods included applying system coded...
Advances in machine learning (ML) methodologies, combined with multidisciplinary collaborations across biological and physical sciences, has the potential to propel drug discovery development. Open Science fosters this collaboration by releasing datasets methods into public space; however, further education widespread acceptance adoption of approaches are necessary tackle plethora known disease states.
Major depressive disorder (MDD) is a prevalent and debilitating psychiatric disease that leads to substantial loss of quality life. There has been little progress in developing new MDD therapeutics due poor understanding heterogeneity individuals' responses treatments. Electroencephalography (EEG) poised improve this, owing the ease large-scale data collection advancement computational methods address artifacts. This review summarizes viability EEG for brain-based biomarkers MDD. We examine...
Cellular changes that occur within the liver before and during fibrosis have been studied. At various times (0-90 days) after gamma irradiation (0-25 Gy) of whole liver, hepatocytes nonparenchymal cells were isolated by enzymatic dissociation differential centrifugation. Differential cell counts done to quantify yield cells. Hepatocyte function in vitro was assayed uptake rose bengal compared with clearance dye vivo. Intracellular alanine aminotransferase (ALT) aspartate (AST) used estimate...
The interval between X-irradiation of the lumbar spinal cord mice and onset hindquarter paralysis was observed to be inversely related amount radiation administered. Using l...
Background: Deep brain stimulation (DBS) is a neurosurgical intervention with demonstrated effectiveness for treatment resistant depression (TRD), but longitudinal studies on the stability of cognitive parameters following are limited. The objectives this study to (i) identify baseline predictors response subcallosal cingulate gyrus (SCG) DBS unipolar TRD and (ii) compare neurocognitive performance prior 12 months after implantation. Methods: Twenty patients received SCG months. A...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited effective therapeutic options. Gemcitabine plus nab-Paclitaxel (GnP) and FOLFIRINOX (FFX) are commonly used first-line chemotherapies for advanced PDAC. However, disease heterogeneity late-stage diagnosis remain to result in poor prognosis. There need predictive biomarkers selecting patients likely respond either regimen. Here, we analyzed data from the COMPASS trial identify mutational...
The whole livers of rats were exposed intraoperatively to graded doses (0 75 Gy) 137Cs gamma radiation. At various times 155 days) after liver irradiation, minimally invasive, nondestructive tests (rose bengal retention and plasma alkaline phosphatase, glutamic-oxaloacetic acid transaminase, glutamic-pyruvic transaminase) performed on at least half the surviving animals in each dose group assess developing injury. Liver histology was done sacrificed 96 100 days irradiation. Radiation damage...
Rats were whole-body irradiated with 8-MeV cyclotron-produced neutrons and 137Cs gamma rays to study the role of enteric bacteria endotoxin in intestinal radiation syndrome. Decrease weight was used as an index radiation-induced breakdown mucosa. Neutron gamma-ray doses that sublethal for death resulted a dose-dependent decrease weight, reaching minimal values 2 3 days after exposure, followed by recovery within 5 irradiation. photon caused greater mucosal little or no evidence recovery. The...
Dexamethasone (DEX) and captopril are effective drugs in the treatment of radiation nephropathy experimental animals. The aim present study was to determine relative effectiveness two see if their combination is more than either drug alone. For this purpose both kidneys 143 rats were exposed surgically irradiated with 13-20 Gy gamma rays. surrounding tissues, exception a segment lumbar cord, shielded. Each group had free access acidified drinking water containing DEX (94 micrograms/l), (500...
Testicular damage as measured by decreased incorporation of labeled tracers, testes weight, or DNA content has been investigated a possible biological test system for intercomparing fast ...