A5010961636- Treatment of Major Depression
- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Balance, Gait, and Falls Prevention
- Mental Health Treatment and Access
- Tryptophan and brain disorders
- Cardiac Health and Mental Health
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Cerebral Palsy and Movement Disorders
- Mental Health and Psychiatry
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Health and Well-being Studies
- Child and Adolescent Psychosocial and Emotional Development
- Intensive Care Unit Cognitive Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disorders and Treatments
- Perfectionism, Procrastination, Anxiety Studies
- EEG and Brain-Computer Interfaces
University of Toronto
2016-2025
University Health Network
2016-2025
Toronto Rehabilitation Institute
2008-2025
Centre for Mental Health
2018-2024
Toronto Dementia Research Alliance
2024
Toronto General Hospital
2002-2023
University of Massachusetts Chan Medical School
2023
RELX Group (Netherlands)
2020-2023
Health Net
2017-2021
University of Birmingham
2020
Depression is a heterogeneous mental illness. Neurostimulation treatments, by targeting specific nodes within the brain's emotion-regulation network, may be useful both as therapies and probes for identifying clinically relevant depression subtypes.Here, we applied 20 sessions of magnetic resonance imaging-guided repetitive transcranial stimulation (rTMS) to dorsomedial prefrontal cortex in 47 unipolar or bipolar patients with medication-resistant major depressive episode.Treatment response...
Despite its high toll on society, there has been little recent improvement in treatment efficacy for major depressive disorder (MDD). The identification of biological markers successful response may allow more personalized and effective treatment. Here we investigate whether resting-state functional connectivity predicted to with repetitive transcranial magnetic stimulation (rTMS) dorsomedial prefrontal cortex (dmPFC). Twenty-five individuals treatment-refractory MDD underwent a 4-week...
The benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied. Download a PDF the Research Summary. We conducted two-step, open-label trial involving 60 years age depression. In step 1, patients were randomly assigned 1:1:1 ratio to augmentation existing antidepressant medication aripiprazole, bupropion, switch from bupropion. Patients who did benefit ineligible for 1 2 1:1 lithium nortriptyline. Each...
OBJECTIVE: Atypical antipsychotics are thought not to elevate prolactin levels. The authors examined data suggesting that atypical do levels but more transiently than typical antipsychotics. METHOD: Prolactin in 18 male patients with schizophrenia who were receiving monitored over the 24-hour period following administration of their daily oral dose risperidone, olanzapine, or clozapine. RESULTS: baseline risperidone (mean=27 ng/ml, SD=14) abnormally high, olanzapine (mean=9 SD=5) and...
Working memory deficits are common among individuals with Alzheimer's dementia (AD) or mild cognitive impairment (MCI). Yet, little is known about the mechanisms underlying these deficits. Theta-gamma coupling-the modulation of high-frequency gamma oscillations by low-frequency theta oscillations-is a neurophysiologic process working memory. We assessed relationship between theta-gamma coupling and in AD MCI. hypothesized that: (1) would display most significant impairments followed MCI...
Autobiographical memory in major depression has been characterized as overgeneralized, with patients recalling few episodic details, prioritizing general schematic events. However, whether this effect reflects impaired or semantic memory, domain-general cognitive processes, is unknown. We used the Interview (Levine, Svoboda, Hay, Winocur, & Moscovitch, 2002) to derive and contributions autobiographical severe depression. also assessed for public events famous people. Depressed were on...
Prescriptions for antipsychotic medications continue to increase across many brain disorders, including off-label use in children and elderly individuals. Concerning animal uncontrolled human data suggest antipsychotics are associated with change structure, but our knowledge, there no controlled studies that have yet addressed this question.To assess the effects of on structure humans.Prespecified secondary analysis a double-blind, randomized, placebo-controlled trial over 36-week period at...
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Abstract Background Alzheimer’s dementia (AD) is associated with electroencephalography (EEG) abnormalities including in the power ratio of beta to theta frequencies. EEG studies mild cognitive impairment (MCI) have been less consistent identifying such abnormalities. One potential reason not excluding aperiodic components, which are cognition than periodic components. Here, we investigate whether and components disrupted differently AD or MCI vs. healthy control (HC) individuals a based...
Fall risk is high for older adults with dementia. Gait impairment contributes to increased fall risk, and gait changes are common in people dementia, although the reliable assessment of challenging this population. This study aimed develop an automated approach performing assessments based on data that collected frequently unobtrusively, analysed using computer vision methods. Recent developments have led availability open source human pose estimation algorithms, which automatically estimate...
<h3>Importance</h3> Psychotic depression is a severely disabling and potentially lethal disorder. Little known about the efficacy tolerability of continuing antipsychotic medication for patients with psychotic in remission. <h3>Objective</h3> To determine clinical effects once an episode has responded to combination treatment antidepressant agent. <h3>Design, Setting, Participants</h3> Thirty-six week randomized trial conducted at 4 academic medical centers. Patients aged 18 years or older...
Falls are a leading cause of morbidity and mortality in older adults with dementia residing long-term care. Having access to frequently updated accurate estimate the likelihood fall over short time frame for each resident will enable care staff provide targeted interventions prevent falls resulting injuries. To this end, machine learning models update risk within next 4 weeks were trained on longitudinal data from 54 adult participants dementia. Data participant included baseline clinical...
To examine the independent association of depression following acute stroke with impairment in activities daily living (ADL), authors conducted a cross-sectional analysis patients enrolled Stroke Data Bank (U.S.A.) who had completed Center for Epidemiological Studies Depression Scale (CES-D). Scores on Barthel Index, measure ADL, were compared between depressed (CES-D > or = 16) and nondepressed < 15) at 7-10 days after stroke. Of 626 CES-D, 160 depressed. Depressed evidenced greater ADL...