A5009127768- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Tryptophan and brain disorders
- Treatment of Major Depression
- Mental Health and Psychiatry
- Stress Responses and Cortisol
- Adolescent and Pediatric Healthcare
- Suicide and Self-Harm Studies
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Maternal Mental Health During Pregnancy and Postpartum
- Neurology and Historical Studies
- Psychoanalysis and Psychopathology Research
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Obsessive-Compulsive Spectrum Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Psychiatric care and mental health services
Centre National de la Recherche Scientifique
2016-2025
Institut de Neurosciences de la Timone
2018-2025
Université de Montpellier
2023-2025
Centre Hospitalier Universitaire de Montpellier
2021-2025
Fondation FondaMental
2016-2025
Hôpital Albert-Chenevier
2015-2025
Inserm
2017-2025
Institut de Génomique Fonctionnelle
2022-2025
Assistance Publique Hôpitaux de Marseille
2015-2024
Aix-Marseille Université
2015-2024
Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the pathway linking basolateral amygdala to anterior cingulate cortex is essential for pain-induced depression. Moreover, activation this naive male mice, absence on-going pain, sufficient trigger depressive-like behaviors, as well transcriptomic alterations recapitulate core molecular features...
To date, it remains impossible to guarantee that short-term treatment given a patient suffering from major depressive episode (MDE) will improve long-term efficacy. Objective biological measurements and biomarkers could help in predicting the clinical evolution of MDE are still warranted. better understand reason nearly half patients respond poorly current antidepressive treatments, we examined gene expression profile peripheral blood samples collected 16 severe 13 matched controls. Using...
The cortico-limbic system is critically involved in emotional responses and resulting adaptive behaviors. Within this circuit, complementary regions are believed to be either the appraisal or regulation of affective state. However, respective contribution these bottom-up top-down mechanisms during emotion processing remains clarified. We used a new functional magnetic resonance imaging (fMRI) paradigm varying 3 parameters: valence, congruency, allocation attention, distinguish variation...
As almost all mental disorders are associated with increased suicidal-related behavior, anhedonia might be a trans-diagnostic dimension to target for suicide prevention.For this 3-year-long prospective study, 2,839 outpatients mood were recruited. They divided in: (a) two groups according the occurrence or not of suicidal ideation during follow-up, and (b) attempts follow-up. Anhedonia was assessed using composite score (the French version 14-item Snaith-Hamilton Pleasure Scale item 13 Quick...
Persistent functional impairment is common in bipolar disorder (BD) and influenced by a number of demographic, clinical, cognitive features. The goal this project was to estimate compare the influence key factors on community function multiple cohorts well-characterized samples individuals with BD.Thirteen from 7 countries included n = 5882 BD across sites. statistical approach consisted systematic uniform application analyses Each site performed logistic regression analysis empirically...
Poor adherence to medication is frequent in bipolar disorder (BD) and has been associated with several factors. To date, the relationship between low neuropsychological functioning BD still unclear. As age might have opposing influences on adherence, our aim was investigate this link a particular focus effect of age.In cross-sectional study, we included 353 patients divided into two age-groups (16-46; 47-71) from French cohort diagnosed (type I, II, NOS) strictly euthymic. All had...
Abstract It remains unclear why many patients with depression do not respond to antidepressant treatment. In three cohorts of individuals and treated serotonin-norepinephrine reuptake inhibitor ( N = 424) we show that responders, but non-responders, display an increase GPR56 mRNA in the blood. a small group subjects also is downregulated PFC died by suicide. mice, chronic stress-induced Gpr56 downregulation blood prefrontal cortex (PFC), which accompanied depression-like behavior, can be...
Abstract Major depressive disorder (MDD) is primarily treated with antidepressants, yet many patients fail to respond adequately, and identifying antidepressant response biomarkers thus of clinical significance. Some hypothesis-driven investigations epigenetic markers for treatment have been previously made, but genome-wide approaches remain unexplored. Healthy participants ( n = 112) MDD 211) between 18–60 years old were recruited an 8-week trial escitalopram treatment. Responders...
Although cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods euthymia, little is known about phenotype heterogeneity among patients with BD.We investigated neuropsychological performance in 258 euthymic BD recruited via the French network expert centers for BD. We used test battery assessing six domains cognition. Hierarchical cluster analysis cross-sectional data was to determine optimal number subgroups and assign each patient specific cluster....
Abstract Bipolar disorder (BD) has been associated with premature cellular aging shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals prematurely TL. The aims present study were replicate this observation in larger sample and analyze expression levels genes age or TL subsample these individuals. was measured on peripheral blood DNA using quantitative polymerase chain reaction 542 BD clustering analyses performed. Gene...