Cynthia Marie‐Claire
A5114374166- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Genetic Syndromes and Imprinting
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Adolescent and Pediatric Healthcare
- Genetic Associations and Epidemiology
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Cannabis and Cannabinoid Research
- Schizophrenia research and treatment
- Forensic Toxicology and Drug Analysis
- Peptidase Inhibition and Analysis
- Child and Adolescent Psychosocial and Emotional Development
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Telomeres, Telomerase, and Senescence
- Psychological and Temporal Perspectives Research
- Signaling Pathways in Disease
- Child Abuse and Trauma
Inserm
2016-2025
Université Paris Cité
2016-2025
Optimisation Thérapeutique en Neuropsychopharmacologie
2019-2025
Hôpital Lariboisière
2024
Assistance Publique – Hôpitaux de Paris
2021-2024
Hypertension pulmonaire : physiopathologie et innovation thérapeutique
2022-2024
Université de Strasbourg
2024
Sorbonne Paris Cité
2012-2024
Institut des Neurosciences Cellulaires et Intégratives
2024
Centre National de la Recherche Scientifique
1999-2023
Abstract Objectives Genome‐wide association studies (GWAS) have become increasingly popular to identify associations between single nucleotide polymorphisms (SNPs) and phenotypic traits. The GWAS method is commonly applied within the social sciences. However, statistical analyses will need be carefully conducted use of dedicated genetics software required. This tutorial aims provide a guideline for conducting genetic analyses. Methods We discuss explain key concepts illustrate how conduct...
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action incompletely understood, and prediction outcomes limited. In our previous multi-omics study Pharmacogenomics Bipolar Disorder (PGBD) sample combining transcriptomic genomic data, we found that focal adhesion, extracellular matrix (ECM), PI3K-Akt signaling networks were associated with response to lithium. this study, replicated results using network propagation methods in a genome-wide...
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health that affects about 1% of population worldwide. Nevertheless, lithium not consistently effective, with only 30% patients showing favorable response to treatment. To provide personalized options patients, it essential identify prediction biomarkers such polygenic scores. In this study, we developed score (Li + PGS ) in BD. gain further insights into lithium’s possible...
Abstract The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we performed exploratory study the contributions immune-relevant genetic factors to response lithium (Li) treatment clinical presentation BP. First, assessed association large collection immune-related genes (4925) with Li response, defined by...
Little is known about the cellular effects induced by 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy), although changes in gene expression have been observed following treatments with other psychostimulants. Thus, aim of this study was to investigate mice, relationships between ras‐dependent protein kinase ERK and MDMA‐induced reinforcement using conditioned place preference (CPP) locomotor activity measurements. This completed real‐time quantitative PCR method a immediate early‐genes...
The molecular components ensuring the strict exopeptidase action of aminopeptidase N (APN) and related zinc aminopeptidases M1 family have not yet been clearly established. specific recognition N-terminal amino acid substrates by enzymes has proposed to involve either complexation free group catalytic ion or an interaction with anionic binding site, which could be constituted aspartate glutamate residue. To investigate existence such ionic site-directed mutagenesis experiments performed on...
Objectives: We examine whether the lithium response is associated with changes in expression of core clock genes.Methods: The effect a therapeutic concentration (1 mM) on levels 17 circadian genes was examined lymphoblastoid cell lines (LCLs) derived from two well-characterized groups bipolar disorder patients, defined as non-responders (NR, n = 20) or excellent responders (ER, 16). Quantitative real-time PCR (qRT-PCR) conducted at 2, 4 and 8 days (d2, d4 d8) without exposure.Results: At d2,...
Abstract The 10–15-years decrease in life expectancy observed individuals with bipolar disorder (BD) has been linked to the concept of accelerated cellular aging. Telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) have proposed as markers aging comparisons between BD healthy controls (HC) sometimes led conflicting results. Previous studies had moderate sample sizes combining these two into a single analysis are scarce. Using quantitative polymerase chain reaction, we measured...
Abstract Background Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce long-term burden mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial on disease-associated conditions, including sleep cardiovascular disorders. However, individual responses Li vary within between diagnostic subtypes BP (e.g. BP-I BP-II) according clinical presentation. Moreover, linked adverse side-effects that...
Preliminary studies suggest that lithium (Li) response might be associated with some circadian gene polymorphisms, we therefore performed a pharmacogenetic study on the core clock genes in two independent samples suffering from bipolar disorder ( BD ) and thoroughly characterized for their Li response. Two Caucasian (165 58 patients) treated were selected recruited French multicenter assessed using Alda scale. The genotyped Human660 H660 OmniExpress OE BeadChips gene‐based association...
Abstract Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker available to reliably define eligibility criteria a with Li. We examined whether prophylactic Li (assessed retrospectively) associated distinct blood DNA methylation profiles. Bisulfite-treated total samples from individuals BD type 1 (15 excellent-responders (LiERs) versus 11 non-responders (LiNRs)) were used targeted...
Abstract Bipolar disorder (BD) has been associated with premature cellular aging shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals prematurely TL. The aims present study were replicate this observation in larger sample and analyze expression levels genes age or TL subsample these individuals. was measured on peripheral blood DNA using quantitative polymerase chain reaction 542 BD clustering analyses performed. Gene...
Morphine may affect the properties of blood-brain barrier (BBB) by modifying expression certain BBB markers. We have determined effect chronic morphine treatment on and function some markers in rat. The mRNAs 19 selected genes encoding caveolins, endothelial transporters, receptors tight junctions proteins total RNA isolated cortex microvessels were assayed quantitative RT-PCR (qRT-PCR). Mdr1a, Mrp1, Bcrp, Glut-1 Occludin, was slightly increased, while that Flk-1 decreased from...
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium the best-established long-term treatment for BD, even though individual response variable. Evidence suggests that some this variability has genetic basis. This supported largest genome-wide association study (GWAS) lithium to date conducted International Consortium on Genetics (ConLiGen). Recently, we performed first analysis involvement miRNAs in...
Abstract Background Polygenic scores (PGSs) hold the potential to identify patients who respond favourably specific psychiatric treatments. However, their biological interpretations remain unclear. In this study, we developed pathway-specific PGSs (PS PGS ) for lithium response and assessed association with clinical in bipolar disorder (BD). Methods Using sets of genes involved pathways affected by lithium, nine PS evaluated associations International Consortium on Lithium Genetics cohort...