A5091397491- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Genetic Associations and Epidemiology
- Psychosomatic Disorders and Their Treatments
- COVID-19 and Mental Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health disparities and outcomes
- Health, psychology, and well-being
- Neuroendocrine regulation and behavior
- Genetic Syndromes and Imprinting
- Long-Term Effects of COVID-19
- Genetics and Neurodevelopmental Disorders
- Smoking Behavior and Cessation
- Clinical Reasoning and Diagnostic Skills
- Healthcare Decision-Making and Restraints
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Behavioral Health and Interventions
- Neural dynamics and brain function
- Mental Health and Psychiatry
University of Tübingen
2024
IU International University of Applied Sciences
2024
Deutsche Knochenmarkspenderdatei
2021-2024
Felix Platter-Hospital
2021-2024
Idaho National Laboratory
2024
Universitätsmedizin Göttingen
2011-2023
University of Göttingen
2010-2023
University of Basel
2022
Medical College of Wisconsin
2010-2018
Cardinal Stritch University
2006-2010
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying sources of can help generate novel clinical hypotheses etiology assist in development biomarkers for indexing disease progression prognosis. Here we were interested case-control differences intracranial volume (ICV) each eight subcortical measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a...
Abstract Background Misdiagnosing bipolar depression can lead to very deleterious consequences of mistreatment. Although depressive symptoms may be similarly expressed in unipolar and disorder, changes specific brain networks could distinct, being therefore informative markers for the differential diagnosis. We aimed characterize alterations candidate large‐scale (frontoparietal, cingulo‐opercular, default mode) symptomatic patients using resting state fMRI, a cognitively low demanding...
Schizophrenia and depression are prevalent psychiatric disorders, but their underlying neural bases remains poorly understood. Neuroimaging evidence has pointed towards the relevance of functional connectivity aberrations in default mode network (DMN) hubs, dorso-medial prefrontal cortex precuneus, both commonalities differences resting state those two regions across disorders not been formally assessed. Here, we took a transdiagnostic approach to investigate 75 patients with schizophrenia...
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health that affects about 1% of population worldwide. Nevertheless, lithium not consistently effective, with only 30% patients showing favorable response to treatment. To provide personalized options patients, it essential identify prediction biomarkers such polygenic scores. In this study, we developed score (Li + PGS ) in BD. gain further insights into lithium’s possible...
Abstract The Covid-19 pandemic highly impacts mental health worldwide. Patients with psychiatric disorders are a vulnerable risk population for worsening of their condition and relapse symptoms. This study investigates the pandemic-related course psychosocial burden in patients pre-existing disorders. With newly developed Goettingen Burden Symptom Inventory (Goe-BSI) has been traced retrospectively (1) before (beginning 2020), (2) at its beginning under maximum lockdown conditions (March (3)...
Abstract Background Polygenic scores (PGSs) hold the potential to identify patients who respond favourably specific psychiatric treatments. However, their biological interpretations remain unclear. In this study, we developed pathway-specific PGSs (PS PGS ) for lithium response and assessed association with clinical in bipolar disorder (BD). Methods Using sets of genes involved pathways affected by lithium, nine PS evaluated associations International Consortium on Lithium Genetics cohort...
In a laboratory smoking experiment, 25 couples in which 1 or both partners continued to smoke despite of them having heart lung disease discussed health-related disagreement before and during period smoking. Immediately afterward, the used independent joysticks recall their continuous emotional experience interaction while watching themselves on video. Participants dual-smoker reported increased positive emotion contingent upon lighting up, whereas those single-smoker opposite. The results...
While the COVID-19 pandemic continues, patients with pre-existing mental disorders are increasingly recognized as a risk group for adverse outcomes. However, data conflicting and cover only short time spans so far. Here, we investigate medium-term peri-lockdown-related changes of health outcomes in such longitudinal study. A cohort 159 comprising all major (ICD-10 F0-F9) were interviewed twice Goettingen psychosocial Burden Symptom Inventory (Goe-BSI) to evaluate burden, psychiatric symptoms...
Monoclonal antibodies prepared to human myelin-associated glycoprotein were shown react with a population of peripheral blood mononuclear cells. The is similar the large granular lymphocytes or natural killer cells defined by antibody Leu 7 (also called HNK-1). also includes exhibiting 2 marker for suppressor/cytotoxic T results indicate shared antigenicity between nervous system and immune may be relevant pathogenesis demyelinating diseases.
Recent functional neuroimaging studies have provided evidence that human verbal working memory is represented by two complementary neural systems, a left lateralized premotor-parietal network implementing articulatory rehearsal and presumably phylogenetically older bilateral anterior-prefrontal/inferior-parietal subserving non-articulatory maintenance of phonological information. In order to corroborate these findings from neuroimaging, we performed targeted behavioural study in patients...
Voxel-based morphometry (VBM) is a commonly used method to study volumetric variations on whole brain basis. However, it often criticized for potential confounds, mainly based imperfect spatial registration. We therefore aimed evaluate if VBM and "gold standard" manual volumetry are measuring the same effects with respect subcortical gray matter volumes. Manual regions-of-interest were drawn in hippocampus, amygdala, nucleus accumbens, thalamus, putamen, pallidum, caudate bilaterally....
HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine impact genotype on severity SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into supertypes by functional or predicted structural similarities peptide-binding grooves did not predict COVID-19 severity. Further, observe a heterozygote advantage benefit diplotypes with...
DTNBP1 is one of the most established susceptibility genes for schizophrenia, and hippocampal volume reduction major neuropathological findings in this severe disorder. Consistent with these findings, encoded protein dysbindin-1 has been shown to be diminished glutamatergic neurons schizophrenic patients. The aim study was investigate effects two single nucleotide polymorphisms on grey matter volumes human subjects using voxel-based morphometry. Seventy-two were included genotyped respect...
Cyclic AMP response element-binding protein (CREB) contributes to adaptation of mesocorticolimbic networks by modulating activity-regulated transcription and plasticity in neurons. Activity or expression changes CREB the nucleus accumbens (NAc) orbital frontal cortex (OFC) interact with behavioral during reward-motivated learning. However, these findings from animal models have not been evaluated humans. We tested whether CREB1 genotypes affect decisions related brain activation, using BOLD...