A5015808096- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Mental Health Research Topics
- Electrolyte and hormonal disorders
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurotransmitter Receptor Influence on Behavior
- Problem Solving Skills Development
- Pharmacological Effects and Toxicity Studies
- Memory and Neural Mechanisms
- Fetal and Pediatric Neurological Disorders
- Sexuality, Behavior, and Technology
- Perfectionism, Procrastination, Anxiety Studies
- Sex and Gender in Healthcare
- Genomics and Rare Diseases
- Adrenal Hormones and Disorders
- Obsessive-Compulsive Spectrum Disorders
- Adolescent and Pediatric Healthcare
- Transcranial Magnetic Stimulation Studies
King's College London
2017-2025
National Institute of Mental Health
2024
National Institutes of Health
2024
South London and Maudsley NHS Foundation Trust
2021-2023
National Health Service
2023
Maudsley Hospital
2023
Bethlem Royal Hospital
2022
Dokuz Eylül University
2013-2019
University of North Carolina at Chapel Hill
2014
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
Cognitive remediation therapy (CRT) may benefit people with bipolar disorder type I and II for whom cognitive impairment is a major contributor to disability. Extensive research has demonstrated CRT improve cognition psychosocial functioning in different diagnoses, but randomised trials of evidenced programmes are lacking disorders. The Remediation Bipolar (CRiB) study aimed determine whether an established programme feasible acceptable disorders.This proof-of-concept, single-blind trial...
Background Several lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation unaffected first-degree relatives BD patients may help to distinguish structural biomarkers genetic risk without the confounding effects burden illness, medication or clinical state. In present study, we applied tract-based spatial statistics study WM changes in BD, siblings and controls. Method A total 27 euthymic type I, 20 29 healthy controls who did not...
Objectives The current study aimed to assess both response inhibition ( RI ) and interference control IC in euthymic patients with bipolar disorder BD ‐Ps) as well asymptomatic first‐degree relatives ‐Rs) healthy controls HC s) order evaluate trait‐as opposed illness‐associated features of these components. Methods ‐Ps (n = 35) who had been the state for at least six months, ‐Rs 30), s 33) completed a Stop‐Signal Task SST Stroop , respectively. Groups were compared on stop‐signal reaction...
Abstract: Depression accounts for the predominant burden associated with bipolar disorder. The identification and management of depression are challenging, since differs from unipolar depression, responding poorly to traditional antidepressants, which may also induce a switch hypomania/mania, mixed states and/or cause rapid cycling. Current treatment options limited guidelines vary greatly in their recommendations, reflecting gaps inconsistencies current evidence base. Moreover, some...
So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed examine CT SA differences between BDI, FR healthy controls (HC). 3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected 29 HC. obtained with FreeSurfer version 5.3.0. Generalized estimating equations used compare groups. Group comparisons...
Introduction: This study aimed to assess the reliability and validity of Turkish version The DSM-5 Level 2 Depression Scale. Method: group included a case that consisted clinical sample diagnosed with depressive disorder continued treatment in child adolescent psychiatry unit community sample. was carried out 218 children 160 parents. Child Inventory Strengths Difficulties Questionnaire- Parent Form were used along Scale for assessment. Results: In analyses, Cronbach alpha internal...