Torbjørn Elvsåshagen
A5036872905- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Epigenetics and DNA Methylation
- Sleep and Wakefulness Research
- Health, Environment, Cognitive Aging
- Electrolyte and hormonal disorders
- Genetic Syndromes and Imprinting
- Sleep and related disorders
- Birth, Development, and Health
- Heart Rate Variability and Autonomic Control
- Personality Disorders and Psychopathology
- Sleep and Work-Related Fatigue
- Neuroscience and Music Perception
- Telomeres, Telomerase, and Senescence
- Diet and metabolism studies
- Bioinformatics and Genomic Networks
Oslo University Hospital
2016-2025
University of Oslo
2016-2025
Weatherford College
2024
Broad Institute
2019
Institute of Clinical Research
2013
Smerteklinikken
2008
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying sources of can help generate novel clinical hypotheses etiology assist in development biomarkers for indexing disease progression prognosis. Here we were interested case-control differences intracranial volume (ICV) each eight subcortical measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
The neuropeptide oxytocin has shown promise as a treatment for symptoms of autism spectrum disorders (ASD). However, clinical research progress been hampered by poor understanding oxytocin's dose-response and sub-optimal intranasal delivery methods. We examined two doses delivered using novel Breath Powered device designed to improve direct nose-to-brain activity in double-blind, crossover, randomized, placebo-controlled trial. In randomized sequence single-dose sessions, 17 male adults with...
ABSTRACT Bipolar disorder is a highly heritable psychiatric that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases 31,358 controls European descent, with follow-up analysis 822 sentinel variants at loci P<1×10 -4 in an independent sample 9,412 137,760 controls. In combined analysis, 30 reached significant evidence for association, which 20 were novel. These contain genes encoding ion channels neurotransmitter...
Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It unclear whether such alterations progressively change over time, how this related to the number of mood episodes. To address question, we analyzed a large diverse international sample longitudinal magnetic resonance imaging (MRI) clinical data examine changes time in BD.Longitudinal MRI from ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307...
Background Elucidating the neurobiological effects of sleep and waking remains an important goal neurosciences. Recently, animal studies indicated that is for cell membrane myelin maintenance in brain these structures are particularly susceptible to insufficient sleep. Here, we tested hypothesis a day deprivation would be associated with changes diffusion tensor imaging (DTI) indices white matter microstructure sensitive axonal alterations. Methods Twenty-one healthy adult males underwent...
Abstract Background Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in MDD patients, whether this process clinical characteristics a large multi-center international dataset. Methods performed mega-analysis by pooling measures derived from T1-weighted MRI scans 29 samples worldwide. Normative was estimated predicting chronological age (10-75 years) 7 subcortical volumes, 34...
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that part of a psychosis continuum, dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific mechanisms SMI not known yet. Recently, dyslipidemia has linked systemic inflammasome activation, elevated atherogenic lipid ratios shown correlate with circulating levels inflammatory biomarkers SMI. It is, however, yet if increased cholesterol load leads...
The thalamus is a vital communication hub in the center of brain and consists distinct nuclei critical for consciousness higher-order cortical functions. Structural functional thalamic alterations are involved pathogenesis common disorders, yet genetic architecture remains largely unknown. Here, using scans genotype data from 30,114 individuals, we identify 55 lead single nucleotide polymorphisms (SNPs) within 42 loci 391 genes associated with volumes its nuclei. In an independent validation...
Objectives The neurobiological substrate of bipolar II disorder (BD-II) remains largely unknown. A few previous studies have found evidence for cerebral cortical thinning in mixed samples BD-II and I patients; however, no study thickness or surface area has been limited to BD-II. In the present study, we compared magnetic resonance imaging (MRI)-based indices between individuals with healthy controls. Methods Thirty-six a DSM-IV diagnosis 42 controls underwent 3T MRI. Comparisons relative...