A5040266732- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Lanthanide and Transition Metal Complexes
- Hemoglobinopathies and Related Disorders
- Fetal and Pediatric Neurological Disorders
- Cardiac Imaging and Diagnostics
- Health, Environment, Cognitive Aging
- Cardiovascular Health and Disease Prevention
- Glioma Diagnosis and Treatment
- Bone and Joint Diseases
- HIV-related health complications and treatments
- HIV Research and Treatment
- Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Radiomics and Machine Learning in Medical Imaging
- Machine Learning in Healthcare
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2020-2025
Amsterdam Neuroscience
2019-2025
Ghent University
2019-2024
University of Amsterdam
2016-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2024
Radboud University Medical Center
2017-2024
Radboud University Nijmegen
2017-2024
University of California, San Diego
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
This article focuses on clinical applications of arterial spin labeling (ASL) and is part a wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group to update expand recommendations provided 2015 ASL consensus paper. Although paper general guidelines MRI, there was lack guidance disease‐specific parameters. Since that time, availability demand MRI has increased. position provides using specific scenarios, including acute ischemic stroke...
Abstract Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision‐making. This guidelines article provides a comprehensive overview quantitative imaging brain using multi‐timepoint arterial spin labeling (ASL), along with recommendations its acquisition quantification. A major benefit acquiring ASL data multiple label durations and/or post‐labeling delays (PLDs) being able to...
Response to antidepressant treatment in major depressive disorder varies substantially between individuals, which lengthens the process of finding effective treatment. The authors sought determine whether a multimodal machine learning approach could predict early sertraline response patients with disorder. They assessed predictive contribution MR neuroimaging and clinical assessments at baseline after 1 week
Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of acquisition quantification. In community-wide effort towards robust reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers scanners. The procedures used in ExploreASL capitalize published processing advancements address challenges multi-center datasets...
Macro-vascular artifacts are a common arterial spin labeling (ASL) finding in populations with prolonged transit time (ATT) and result vascular regions spuriously increased cerebral blood flow (CBF) tissue decreased CBF. This study investigates whether there is an association between the spatial signal distribution of single post-label delay ASL CBF image ATT. In 186 elderly hypertension (46% male, 77.4 ± 2.5 years), we evaluated associations coefficient variation (CoV) The CoV ATT metrics...
Despite successful antiretroviral therapy, people living with human immunodeficiency virus (PLWH) experience higher rates of age-related morbidity, including abnormal brain structure, function, and cognitive impairment. This has raised concerns that PLWH may accelerated aging-related pathology. We performed a multicenter longitudinal study 134 virologically suppressed (median age, 56.0 years) 79 demographically similar (HIV)–negative controls 57.2 years). To measure performance pathology, we...
Abstract Background We classified non‐demented European Prevention of Alzheimer's Dementia (EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and assessed their neuropsychological imaging profiles. Materials methods From 1500 EPAD participants, 312 were excluded. Cerebrospinal fluid cut‐offs 1000 pg/mL for amyloid beta (Aß)1‐42 27 p‐tau181 validated using Gaussian mixture models. Given strong correlation p‐tau t‐tau (R 2 = 0.98, P < 0.001), neurodegeneration was...
Abstract Magnetic resonance imaging (MRI) technology has profoundly transformed current healthcare systems globally, owing to advances in hardware and software research innovations. Despite these advances, MRI remains largely inaccessible clinicians, patients, researchers low‐resource areas, such as Africa. The rapidly growing burden of noncommunicable diseases Africa underscores the importance improving access equipment well training opportunities on continent. Consortium for Advancement...
Brain-age can be inferred from structural neuroimaging and compared to chronological age (brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer’s disease (AD), but its validation against markers neurodegeneration AD is lacking. Here, imaging-derived measures the UK Biobank dataset (N=22,661) were used predict brain-age 2,314 cognitively unimpaired (CU) individuals at higher risk mild cognitive impaired (MCI)...
Importance Weight loss induced by bariatric surgery (BS) is associated with improved cognition and changed brain structure; however, previous studies on the association have used small cohorts short follow-up periods, making it difficult to determine long-term neurological outcomes BS. Objective To investigate associations of weight after BS structure perfusion. Design, Setting, Participants This cohort study included participants from Bariatric Surgery Rijnstate Radboudumc Neuroimaging...
Arterial spin labelling (ASL) enables non-invasive quantification of regional brain perfusion using MRI. ASL was used in the Reducing Pathology Alzheimer's Disease through Angiotensin TaRgeting (RADAR) multi-centre trial to pilot assessment effects anti-hypertension drug losartan on cerebral blood flow (CBF). In setting, disparities implementation scanners from different manufacturers lead inherent differences measured CBF and its associated parameters (e.g. spatial coefficient variation...
To investigate arterial spin labeling (ASL)-MRI for the early diagnosis of and differentiation between two most common types presenile dementia: Alzheimer's disease (AD) frontotemporal dementia (FTD), distinguishing age-related from pathological perfusion changes. Thirteen AD 19 FTD patients, 25 age-matched older 22 younger controls underwent 3D pseudo-continuous ASL-MRI at 3 T. Gray matter (GM) volume cerebral blood flow (CBF), corrected partial effects, were quantified in entire...
Purpose Prior to the implementation of arterial spin labeling (ASL) in clinical multi-center studies, it is important establish its status quo inter-vendor reproducibility. This study evaluates and compares intra- reproducibility pseudo-continuous ASL (pCASL) as clinically implemented by GE Philips. Material Methods 22 healthy volunteers were scanned twice on both a 3T Philips scanner. The main difference between vendors was readout module: spiral 3D fast echo vs. 2D gradient-echo...
The current study aims to evaluate the neurologic state of perinatally HIV-infected children on combination antiretroviral therapy and attain a better insight into pathogenesis their persistent cognitive deficits.We included between 8 18 years healthy controls matched for age, sex, ethnicity, socioeconomic status. All participants underwent 3.0 T MRI with 3D-T1-weighted, 3D-fluid-attenuated inversion recovery, diffusion-weighted series evaluation cerebral volumes, white matter...
The current study assesses the feasibility and value of crushed cerebral blood flow (CBFcrushed) arterial transit time (ATT) estimations for large clinical imaging studies in elderly with hypertension.Two pseudo-continuous spin labeling (ASL) scans without crushers (CBFnon-crushed) were performed 186 hypertension, from which CBF ATT maps calculated. Standard territory subdivided into proximal, intermediate distal territories, based on measured ATT. coefficient variation (CV) physiological...
Abstract Accurate identification of brain function is necessary to understand neurocognitive aging, and thereby promote health well‐being. Many studies aging have investigated with the blood‐oxygen level‐dependent (BOLD) signal measured by functional magnetic resonance imaging. However, BOLD a composite neural vascular signals, which are differentially affected aging. It is, therefore, essential distinguish age effects on versus function. The variability at rest (known as resting state...