A5053749628- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Gastrointestinal motility and disorders
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Neurological and metabolic disorders
- Dementia and Cognitive Impairment Research
- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Stress Responses and Cortisol
- Dietary Effects on Health
- Enhanced Recovery After Surgery
Radboud University Nijmegen
2023-2024
Radboud University Medical Center
2023-2024
Rijnstate Hospital
2023-2024
The major vascular cause of dementia is cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) amongst others. While the underlying pathology SVD remains unclear, chronic hypertension and neuroinflammation are recognized as important risk factors for conversion normal-appearing (NAWM) to WMH. Unfortunately, most studies investigating role in WMH relied on peripheral blood markers, e.g., markers systemic or inflammation, a proxy inflammation brain itself. However,...
Importance Weight loss induced by bariatric surgery (BS) is associated with improved cognition and changed brain structure; however, previous studies on the association have used small cohorts short follow-up periods, making it difficult to determine long-term neurological outcomes BS. Objective To investigate associations of weight after BS structure perfusion. Design, Setting, Participants This cohort study included participants from Bariatric Surgery Rijnstate Radboudumc Neuroimaging...
Importance Bariatric surgery–induced weight loss is often associated with improved cognitive function. However, improvement in function not always exhibited by all patients, and the mechanisms behind remain unknown. Objective To investigate association of changes adipokines, inflammatory factors, mood, physical activity alterations after bariatric surgery among patients severe obesity. Design, Setting, Participants This cohort study included 156 obesity (body mass index [calculated as...
Obesity is associated with impaired inhibitory control and low-grade systemic inflammation. Systemic inflammation adversely affects neurocognitive performance. Here, we investigate the effects of metabolic bariatric surgery on its influence neural mechanisms underlying control. In a sample 47 individuals obesity, assessed processing pre- 2 years post-bariatric by probing activation connectivity during an fMRI Stroop task. We investigated whether surgery-induced changes in plasma markers were...
Depression and obesity are associated with impaired inhibitory control. Behavioral evidence indicates an exacerbating additive effect when both conditions co-occur. However, the underlying neural mechanisms remain unclear. Moreover, systemic inflammation affects neurocognitive performance in individuals depression obesity. Here, we investigate effects of on correlates control, examine as a connecting pathway.
Abstract Background and Objectives Bariatric surgery (BS) is an effective treatment for obesity. However, some individuals experience insufficient weight loss after surgery. Therefore, we investigated whether cognitive control affects Roux-en-Y gastric bypass (RYGB). Methods Within this exploratory observational study, part of the BARICO study (BAriatric Rijnstate Radboudumc neuroImaging Cognition in Obesity), participants aged between 35 55 years eligible RYGB were included. Before BS, body...
Obesity is a multifactorial disease associated with low-grade inflammation. The gut thought to be involved in obesity-related inflammation, as it continuously exposed antigens from food, microbiota and metabolites. However, the exact underlying mechanisms are still unknown. Therefore, we examined relation between pathology, microbiota, its metabolites cytokines adults severe obesity. Individuals eligible for bariatric surgery were included. Fecal plasma samples collected at timepoint, assess...