A5003141598- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Fetal and Pediatric Neurological Disorders
- Diet and metabolism studies
- Moyamoya disease diagnosis and treatment
- Alzheimer's disease research and treatments
- Cerebrospinal fluid and hydrocephalus
- Adipose Tissue and Metabolism
- Cerebrovascular and genetic disorders
- Regulation of Appetite and Obesity
Radboud University Nijmegen
2019-2025
Radboud University Medical Center
2019-2025
Epilepsy, intellectual and cortical sensory deficits, psychiatric manifestations are the most frequent of mitochondrial diseases. How dysfunction affects neural structure function remains elusive, mostly because a lack proper in vitro neuronal model systems with dysfunction. Leveraging induced pluripotent stem cell technology, we differentiated excitatory neurons (iNeurons) normal (low heteroplasmy) impaired (high on an isogenic nuclear DNA background from patients common pathogenic m.3243A...
The major vascular cause of dementia is cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) amongst others. While the underlying pathology SVD remains unclear, chronic hypertension and neuroinflammation are recognized as important risk factors for conversion normal-appearing (NAWM) to WMH. Unfortunately, most studies investigating role in WMH relied on peripheral blood markers, e.g., markers systemic or inflammation, a proxy inflammation brain itself. However,...
Abstract White matter hyperintensities (WMH) are the most prevalent markers of cerebral small vessel disease (SVD), which is major vascular risk factor for dementia. Microvascular pathology and neuroinflammation suggested to drive transition from normal-appearing white (NAWM) WMH, particularly in individuals with hypertension. However, current imaging techniques cannot capture ongoing NAWM changes. The into WMH a continuous process, yet lesions often examined dichotomously, may explain their...
Introduction: Intracranial arterial calcifications (IAC) are considered a surrogate for intracranial large artery atherosclerosis but IAC can also represent non-atherosclerotic aging. People with have an increased risk of dementia. Nonetheless, the interplay between IAC, atherosclerosis, luminal stenosis and stiffness as determinants neurodegeneration remains unclear. Methods: We analyzed 161 brain autopsy cases from Brain Arterial Remodeling Study. dissected each components circle Willis...
Introduction: Previous studies have shown an association between vascular disease and Alzheimer’s disease, but there are few considered a relationship brain arterial remodeling biomarkers of Alzheimer's disease. Our study aims to find the specific characteristics in pathology. Method: We analyzed 132 autopsy cases from Brain Arterial Remodeling Study (BARS), collection brains multiple banks United States abroad. sections were obtained systematically by each bank, anatomical location was...
Cerebral small vessel disease (SVD) is diagnosed through imaging hallmarks like white matter hyperintensities (WMH). Novel hypotheses imply that endothelial dysfunction, blood-brain barrier (BBB) disruption and neurovascular inflammation contribute to conversion of normal-appearing (NAWM) into WMH in hypertensive individuals. Aiming unravel the association between chronic hypertension earliest pathogenesis, we characterized microvascular pathology periventricular NAWM post-mortem brains...
The long-term impact of stroke on Alzheimer’s disease (AD) progression, particularly regarding sex-specific differences, remains unknown. Using a longitudinal study design, we investigated transient middle cerebral artery occlusion in 3.5-month-old APPswe/PS1dE9 (APP/PS1) and wild-type mice. In vivo, assessed behavior, blood flow (CBF), structural integrity by neuroimaging, as well post-mortem myelin (polarized light imaging, PLI), neuroinflammation, amyloid beta (Aβ) deposition. APP/PS1...
Cerebral small vessel disease is a neurological that affects the brain microvasculature and which commonly observed among elderly. Although at first it was considered innocuous, nowadays regarded as one of major vascular causes dementia. Radiological signs include subcortical infarcts, white matter magnetic resonance imaging hyperintensities, lacunes, enlarged perivascular spaces, cerebral microbleeds, atrophy; however, great heterogeneity in clinical symptoms patients. The pathophysiology...
Exercise and dietary interventions are promising approaches to tackle obesity its obesogenic effects on the brain. We investigated impact of exercise possible synergistic branched-chain amino acids (BCAA) supplementation brain behavior in high-fat-diet (HFD)-induced obese Ldlr−/−.Leiden mice. Baseline measurements were performed chow-fed mice assess metabolic risk factors, cognition, structure using magnetic resonance imaging. Thereafter, a subgroup was sacrificed, serving as healthy...
Abstract The major vascular cause of dementia is cerebral small vessel disease (SVD). Its diagnosis relies on imaging hallmarks, such as white matter hyperintensities (WMH). WMH present a heterogenous pathology, including myelin and axonal loss. Yet, these might be only the “tip iceberg.” Imaging modalities imply that microstructural alterations underlie still normal‐appearing (NAWM), preceding conversion to WMH. Unfortunately, direct pathological characterization affecting myelinated fibers...
Summary Epilepsy, intellectual and cortical sensory deficits psychiatric manifestations are among the most frequent of mitochondrial diseases. Yet, how dysfunction affects neural structure function remains largely elusive. This is mostly due to lack a proper in vitro translational neuronal model system(s) with impaired energy metabolism. Leveraging induced pluripotent stem cell technology, from cohort patients common pathogenic m.3243A>G variant encephalomyopathy, lactic acidosis...