Katharina Dohm
A5034891814- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Child Abuse and Trauma
- Electroconvulsive Therapy Studies
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Stress Responses and Cortisol
- Traumatic Brain Injury Research
- Digital Mental Health Interventions
- Transcranial Magnetic Stimulation Studies
- Health, Environment, Cognitive Aging
- Suicide and Self-Harm Studies
- Mental Health Treatment and Access
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
University of Münster
2016-2025
Jena University Hospital
2022
University Hospital Frankfurt
2022
Goethe University Frankfurt
2022
Friedrich Schiller University Jena
2022
University of Bonn
2021
Philipps University of Marburg
2013-2021
Martin Luther University Halle-Wittenberg
2021
Technische Universität Dresden
2021
University Hospital Münster
2014-2021
<h3>Importance</h3> Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depression. However, biomarkers that accurately predict a response to ECT remain unidentified. <h3>Objective</h3> To investigate whether certain factors identified by structural magnetic resonance imaging (MRI) techniques are able response. <h3>Design, Setting, and Participants</h3> In this nonrandomized prospective study, gray matter structure was assessed twice at approximately 6 weeks...
Major depression has been repeatedly associated with amygdala hyper‐responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is clear whether this “limbic bias” a correlate or represents vulnerability marker preceding the onset disease. Because childhood maltreatment potent risk factor for development major in later life, we explored amygdalar bias maltreated but healthy subjects....
Identifying neurobiological differences between patients with major depressive disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta-analyses have raised concerns regarding the replicability relevance brain alterations in depression.
Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one the most prevalent and disabling disorders, major depressive disorder (MDD), no informative biomarkers have been identified.
Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge. The identification of neurobiological markers may help to differentiate these disorders, particularly during depressive episodes. This cross-sectional study, including 33 patients with UD, BD, and 34 healthy controls, is one the first directly compare UD BD respect reward processing. A card-guessing paradigm was employed brain activity associated processing investigated by means fMRI. 3...
Anhedonia has long been recognized as a key feature of major depressive disorders, but little is known about the association between hedonic symptoms and neurobiological processes in depressed patients. We investigated whether amygdala mood-congruent responses to emotional stimuli patients are correlated with anhedonic at automatic levels processing.We measured responsiveness subliminally presented sad happy facial expressions matched healthy controls using functional magnetic resonance...
Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It unclear whether such alterations progressively change over time, how this related to the number of mood episodes. To address question, we analyzed a large diverse international sample longitudinal magnetic resonance imaging (MRI) clinical data examine changes time in BD.Longitudinal MRI from ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307...
Biased emotion processing has been suggested to underlie the etiology and maintenance of depression. Neuroimaging studies have shown mood-congruent alterations in amygdala activity patients with acute depression, even during early, automatic stages processing. However, due a lack prospective over periods longer than 8 weeks, it is unclear whether these neurofunctional abnormalities represent persistent correlate depression remission. In this case-control study, we aimed examine brain...
More than half of all patients with major depressive disorder (MDD) experience a relapse within 2 years after recovery. It is unclear how affects brain morphologic features during the course MDD.To use structural magnetic resonance imaging to identify changes associated in MDD.In this longitudinal case-control study, acute MDD at baseline and healthy controls were recruited from University Münster Department Psychiatry March 21, 2010, November 14, 2014, reassessed 11, 2012, October 28, 2016....
The absence of neurobiological diagnostic markers bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We investigated if changes in fractional anisotropy (FA) could help differentiate BD from UD the state depression.Using diffusion tensor imaging (DTI) we employed a voxel-based analysis approach examine 86 patients experiencing an acute major depressive episode according DSM-IV (N=39 BD, mean age 39.2 years; N=43 UD, 39.0 years), and 42 healthy controls (HC,...
Abstract It has been difficult to find robust brain structural correlates of the overall severity major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal and investigated this for insomnia, both a key symptom modifiable risk factor MDD. Cortical thickness, surface area subcortical volumes were assessed from T1-weighted magnetic resonance imaging (MRI) scans 1053 MDD patients (age range 13-79 years) 15 cohorts within ENIGMA Working Group. Insomnia was...
Retrospective self-reports of childhood maltreatment (CM) are widely used. However, their validity has been questioned due to potential depressive bias. Yet, investigations this matter sparse. Thus, we investigated what extent retrospective reports vary in relation longitudinal changes symptomatology. Two-year temporal stability was assessed via the Childhood Trauma Questionnaire (CTQ). Diagnosis major disorder (MDD) and symptoms were using Structured Clinical Interview for DSM-IV Beck...
Background Processes of phasic fear responses to threatening stimuli are thought be distinct from sustained, anticipatory anxiety toward an unpredicted, potential threat. There is evidence for dissociable neural correlates and sustained anxiety. Whereas increased amygdala activity has been associated with fear, linked activation the bed nucleus stria terminalis (BNST), anterior cingulate cortex (ACC), insula. So far, only a few studies have focused on dissociation processes related both in...
Obesity has been characterized by alterations in brain structure and function associated with emotion processing regulation. Particularly, aberrations food-related reward have frequently demonstrated obese subjects. However, it remains unclear whether reward-associated functional obesity are specific for stimuli or represent a general deficit processing, extending to other stimulus domains. Given the crucial role of rewarding effects development ongoing discussion on overlapping...
Background Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depression. However, little known regarding brain functional processes mediating ECT effects. Method In a non-randomized prospective study, magnetic resonance imaging data during automatic processing subliminally presented emotional faces were obtained twice, about 6 weeks apart, in patients with major depressive disorder (MDD) before and after treatment (ECT, n = 24). Additionally, control sample...
The investigation of disease course-associated brain structural alterations in Major Depressive Disorder (MDD) have resulted heterogeneous findings, possibly due to low reliability single clinical variables used for defining course. present study employed a principal component analysis (PCA) on multiple investigate effects cumulative lifetime illness burden structure large and sample MDD patients.Gray matter volumes (GMV) was estimated n = 681 patients (mean age: 35.87 years; SD 12.89; 66.6%...