Katharina Brosch
A5078810947- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Health, Environment, Cognitive Aging
- Traumatic Brain Injury Research
- Genetic Associations and Epidemiology
- Suicide and Self-Harm Studies
- Treatment of Major Depression
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Resilience and Mental Health
- Psychosomatic Disorders and Their Treatments
- Neuroscience and Music Perception
- COVID-19 and Mental Health
- Electrolyte and hormonal disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Migration, Health and Trauma
- Obsessive-Compulsive Spectrum Disorders
Philipps University of Marburg
2019-2025
Brain (Germany)
2019-2025
Justus-Liebig-Universität Gießen
2021-2025
Feinstein Institute for Medical Research
2024-2025
Center for Behavioral Brain Sciences
2021-2025
Institute of Behavioral Sciences
2024
Zucker Hillside Hospital
2024
Northwell Health
2024
The Center for Mind-Body Medicine
2023
University of Münster
2021-2022
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one the most prevalent and disabling disorders, major depressive disorder (MDD), no informative biomarkers have been identified.
Abstract Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying layout. We tested large-scale structural in schizophrenia relate to normative and functional connectome architecture, systematically evaluated robustness generalizability of network-level alterations. Leveraging anatomical MRI scans from 2439 adults 2867 healthy controls 26 ENIGMA sites data...
Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It unclear whether such alterations progressively change over time, how this related to the number of mood episodes. To address question, we analyzed a large diverse international sample longitudinal magnetic resonance imaging (MRI) clinical data examine changes time in BD.Longitudinal MRI from ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307...
Abstract Major depressive disorder (MDD), bipolar (BD), and schizophrenia spectrum (SSD, schizophrenia, schizoaffective disorder) overlap in symptomatology, risk factors, genetics, other biological measures. Based on previous findings, it remains unclear what transdiagnostic regional gray matter volume (GMV) alterations exist across these disorders, with which factors they are associated. GMV (3-T magnetic resonance imaging) was compared between healthy controls (HC; n = 110), DSM-IV-TR...
Abstract Schizophrenia is frequently associated with obesity, which linked neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto changes in schizophrenia. We obtained MRI-derived cortical and subcortical measures body mass index (BMI) from 1260 individuals schizophrenia 1761 controls 12 independent research sites within ENIGMA-Schizophrenia Working Group. jointly modeled statistical effects BMI using mixed effects. was additively structure many...
Abstract Up to 70% of patients with major depressive disorder present psychomotor disturbance (PmD), but at the time understanding its pathophysiology is limited. In this study, we capitalized on a large sample examine neural correlates PmD in depression. This study included 820 healthy participants and 699 remitted ( n = 402) or current 297) Patients were further categorized as having retardation, agitation, no PmD. We compared resting-state functional connectivity (ROI-to-ROI) between...
Schizotypy is a risk phenotype for the psychosis spectrum and pilot studies suggest biological continuum underlying this across health disease. It unclear whether might include brain structural associations in networks altered schizophrenia disorders, such as fronto-thalamo-striatal system or nodes of default mode network, precuneus. In study, we analyze large multi-center cohort 673 nonclinical subjects phenotyped schizotypal traits (using Schizotypal Personality Questionnaire-Brief...
Abstract Factorial dimensions and neurobiological underpinnings of formal thought disorders (FTD) have been extensively investigated in schizophrenia spectrum (SSD). However, FTD are also highly prevalent other disorders. Still, there is a lack knowledge about transdiagnostic, structural brain correlates FTD. In N = 1071 patients suffering from DSM-IV major depressive disorder, bipolar or SSD, we calculated psychopathological factor model based on the SAPS SANS scales. We tested association...
Retrospective self-reports of childhood maltreatment (CM) are widely used. However, their validity has been questioned due to potential depressive bias. Yet, investigations this matter sparse. Thus, we investigated what extent retrospective reports vary in relation longitudinal changes symptomatology. Two-year temporal stability was assessed via the Childhood Trauma Questionnaire (CTQ). Diagnosis major disorder (MDD) and symptoms were using Structured Clinical Interview for DSM-IV Beck...
Temporal neural synchrony disruption can be linked to a variety of symptoms major depressive disorder (MDD), including mood rigidity and the inability break cycle negative emotion or attention biases. This might imply that altered dynamic may play role in persistence exacerbation MDD symptoms. Our study aimed investigate changes whole-brain patterns brain functional connectivity activity related depression using hidden Markov model (HMM) on resting-state magnetic resonance imaging (rs-fMRI)...
Abstract Psychiatric disorders show heterogeneous symptoms and trajectories, with current nosology not accurately reflecting their molecular etiology the variability symptomatic overlap within between diagnostic classes. This heterogeneity impedes timely targeted treatment. Our study aimed to identify psychiatric patient clusters that share clinical genetic features may profit from similar therapies. We used high-dimensional data clustering on deep transdiagnostic groups in a discovery...
Abstract Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived subcortical volumes and body mass index (BMI) 1134 1601 control individuals 17 independent research sites within ENIGMA-BD Working Group. jointly modeled BMI using mixed-effects modeling tested for mediation group differences by nonparametric bootstrapping. All...
Background Studying phenotypic and genetic characteristics of age at onset (AAO) polarity (PAO) in bipolar disorder can provide new insights into disease pathology facilitate the development screening tools. Aims To examine architecture AAO PAO their association with characteristics. Method Genome-wide studies (GWASs) polygenic score (PGS) analyses ( n = 12 977) 6773) were conducted patients from 34 cohorts a replication sample 2237). The was investigated two these cohorts. Results Earlier...
The investigation of disease course-associated brain structural alterations in Major Depressive Disorder (MDD) have resulted heterogeneous findings, possibly due to low reliability single clinical variables used for defining course. present study employed a principal component analysis (PCA) on multiple investigate effects cumulative lifetime illness burden structure large and sample MDD patients.Gray matter volumes (GMV) was estimated n = 681 patients (mean age: 35.87 years; SD 12.89; 66.6%...
Childhood maltreatment (CM) represents a potent risk factor for major depressive disorder (MDD), including poorer treatment response. Altered resting-state connectivity in the fronto-limbic system has been reported maltreated individuals. However, previous results smaller samples differ largely regarding localization and direction of effects.We included healthy depressed [n = 624 participants with MDD; n 701 control (HC) participants] that underwent functional MRI measurements provided...
Syntax, the grammatical structure of sentences, is a fundamental aspect language. It remains debated whether reduced syntactic complexity unique to schizophrenia spectrum disorder (SSD) or it also present in major depressive (MDD). Furthermore, association syntax (including and diversity) with language-related neuropsychology psychopathological symptoms across disorders unclear. Thirty-four SSD patients thirty-eight MDD diagnosed according DSM-IV-TR as well forty healthy controls (HC) were...