A5110939889- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Folate and B Vitamins Research
- Traditional Chinese Medicine Studies
- Hemispheric Asymmetry in Neuroscience
- Epigenetics and DNA Methylation
Beijing HuiLongGuan Hospital
2016-2025
Peking University
2015-2025
National Institute of Mental Health
2025
SUNY Upstate Medical University
2025
Yale University
2022
University of Tartu
2022
Stellenbosch University
2020
École Polytechnique Fédérale de Lausanne
2020
University of Basel
2020
Beijing Normal University
2010-2020
Numerous studies argue that cortical reorganization may contribute to the restoration of motor function following stroke. However, evolution changes during post-stroke has been little studied. This study sought identify dynamic in functional organization, particularly topological characteristics, execution network stroke recovery process. Ten patients (nine male and one female) with subcortical infarctions were assessed by neurological examination scanned resting-state magnetic resonance...
Human brain function undergoes complex transformations across the lifespan. We employed resting-state functional MRI and graph-theory approaches to systematically chart lifespan trajectory of topological organization human whole-brain networks in 126 healthy individuals ranging age from 7 85 years. Brain were constructed by computing Pearson's correlations blood-oxygenation-level-dependent temporal fluctuations among 1024 parcellation units followed graph-based network analyses. observed...
A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines data from many institutions worldwide. However, introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether batch adjustment method, ComBat, can further reduce site-related...
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
Although research has provided abundant evidence for Taichi-induced improvements in psychological and physiological well-being, little is known about possible links to brain structure of Taichi practice. Using high-resolution MRI 22 Tai Chi Chuan (TCC) practitioners 18 controls matched age, sex education, we set out examine the underlying anatomical correlates long-term practice at two different levels regional specificity. For this purpose, parcel-wise vertex-wise analyses were employed...
The default-mode network (DMN) is a set of functionally connected regions that play crucial roles in internal cognitive processing. Previous resting-state fMRI studies have demonstrated the intrinsic functional organization DMN undergoes remarkable reconfigurations during childhood and adolescence. However, these mainly focused on cross-sectional designs with small sample sizes, limiting consistency interpretations findings. Here, we used large longitudinal data comprising 305 typically...
Abstract This study aimed to quantify dynamic structural changes in the brain after subcortical stroke and identify areas that contribute motor recovery of affected limbs. High‐resolution MRI neurological examinations were conducted at five consecutive time points during year following 10 patients with left hemisphere infarctions involving pathways. Gray matter volume (GMV) was calculated using an optimized voxel‐based morphometry technique, GMV evaluated a mixed‐effects model. After stroke,...
Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct of structures involved the presumed peripheral-central interaction still unclear. Seventy-nine previously treatment-naïve first-episode patients who were within 2-week antipsychotics initial stabilization, and 41 age- sex-matched healthy controls enrolled study. Group differences subcortical regional measured by MRI subclinical cardiovascular,...
Failure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes resistance are unknown, but it associated earlier age at onset and more severe cognitive deficits. authors tested the hypothesis white matter deficits involved both neurodevelopment severity higher risk resistance.The study sample (N=122; mean age, 38.2 years) included initiation (N=45), whose were responsive (N=40), resistant...
Post-stroke depression (PSD) is one of the most frequent psychiatric disorders after stroke. However, underlying brain mechanism PSD remains unclarified. Using amplitude low-frequency fluctuation (ALFF) approach, we aimed to investigate abnormalities neural activity in patients, and further explored frequency time properties ALFF changes PSD.Resting-state fMRI data clinical were collected from 39 patients (PSD), 82 S without (Stroke), 74 age- sex-matched healthy controls (HC). across three...
<i>Objectives:</i> The mechanism underlying olfactory dysfunction in Parkinson’s disease (PD) remains unknown. current study aims to investigate the relationship between sequential changes of volume change cortex associated with function and degree deficiency performance PD. <i>Methods:</i> Based on arbitrary cut-off score measured by ‘five odors detection arrays’, subjects were classified into three groups: PD patients impairment (OPD, n = 12), without (NPD, 14),...
Numerous studies have reported that the amnestic-type mild cognitive impairment (aMCI) patients impaired brain structural integrity and functional alterations separately.To investigate changes of gray matter amplitude low-frequency oscillations in with aMCI by combining magnetic resonance imaging (fMRI).Thirty-four 34 controls were recruited. We adopted optimized voxel-based morphometry to detect regions volume (GMV) loss induced aMCI. Then regional differences slow-4 band (0.027-0.073 Hz)...
Abstract Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white integrity. We proposed the regional vulnerability index (RVI) to translate results Enhancing Neuro Imaging Genetics Meta‐Analysis studies individual level. calculated RVIs for cortical, subcortical, measurements a multimodality RVI. evaluated RVI as measure sensitive schizophrenia‐specific neuroanatomical symptoms studied timeline...
A dysfunctional default mode network (DMN) has been reported in patients with schizophrenia. However, the stability of deficits not determined across different stages disorder.We examined functional connectivity DMN subsystems 125 first-episode schizophrenia (FES) or recurrent (RES), compared to that 82 healthy controls. We tested robustness findings an independent cohort 158 and 39 performed resting-state analysis, strength connections within between three (core, dorsal medial prefrontal...
Objective To explore differences and similarities in relationships between subcortical structure volumes neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression (MDD), healthy controls (HCs). Methods We presented findings from neurocognitive analyses of 244 subjects (109 patients with FES; 63 BD, 30 MDD, 42 HCs). Using FreeSurfer software, 16 selected structures were automatically segmented analyzed for results seven...
Abstract Background and Hypothesis Population-based morphological covariance networks are widely reported to be altered in schizophrenia. Individualized brain network approaches have emerged recently. We hypothesize that individualized disrupted Study Design constructed single-subject for 203 patients with first-episode schizophrenia (FES) 131 healthy controls separately based on regional cortical thickness (CT), fractal dimension (FD), gyrification index, sulcal depth (SD) by dividing the...