A5100684500- Epigenetics and DNA Methylation
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Cancer-related gene regulation
- Reproductive Biology and Fertility
- Neuroblastoma Research and Treatments
- Plant Stress Responses and Tolerance
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Plant nutrient uptake and metabolism
- Ubiquitin and proteasome pathways
- Plant Gene Expression Analysis
- Ferroptosis and cancer prognosis
- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- Genetic Mapping and Diversity in Plants and Animals
- Traditional Chinese Medicine Analysis
- Receptor Mechanisms and Signaling
- Plant Molecular Biology Research
- Machine Learning in Bioinformatics
- Plant and animal studies
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Renal and related cancers
Jilin Agricultural University
2023-2025
Beijing University of Chinese Medicine
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2020-2025
Wuhan University of Technology
2025
Xi'an Jiaotong University
2020-2025
Yanbian University
2025
Sun Yat-sen University
2017-2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Guizhou University
2021-2024
Abstract According to traditional Chinese medicine (TCM) constitutional theory, individuals with phlegm-dampness constitution (PDC) are at increased risk for metabolic disorders. Previous studies have indicated that PDC exhibit gene expression changes associated disorders, even normal indices. However, the biological mechanisms underlying these remain unclear. The gut microbiota has recently emerged as a promising avenue elucidating TCM principles. Here, we revealed distinct and serum...
N6-methyladenosine (m6A) is the most prevalent epigenetic modification of messenger RNA (mRNA) in higher eukaryotes; this mainly catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as key factor. Although m6A has been proven to play an essential role diverse biological processes, our knowledge Mettl3 still limited because mutations are lethal embryos both mammals and plants. In study, we knocked down microinjection its specific short interfering RNAs (siRNAs)...
All extant core-eudicot plants share a common ancestral genome that has experienced cyclic polyploidizations and (re)diploidizations. Reshuffling of the generates abundant genomic diversity, but role this diversity in shaping hierarchical architecture, such as chromatin topology gene expression, remains poorly understood. Here, we assemble chromosome-level genomes one diploid three tetraploid Panax species conduct in-depth comparative epigenomic analyses. We show chromosomal interactions...
Abstract Background The ferroptosis inhibitory gene Solute carrier family 7 member 11 (SLC7A11) provides a new strategy for anticancer treatment. However, its function in renal cell carcinoma (RCC) remains elusive. Methods expression and somatic mutation information of SLC7A11 RCC samples were determined using Cancer Genome Atlas (TCGA), International Consortium (ICGC), Gene Expression Omnibus (GEO), Oncomine, cBioPortal databases. prognostic value was assessed through survival analysis,...
Can exposure to palmitic acid (PA), a common saturated fatty acid, modulate autophagy in both human and mouse trophoblast cells through the regulation of acyl-coenzyme A-binding protein (ACBP)?
Scientific Report10 January 2017free access Source DataTransparent process The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition Ye Yang State Key Laboratory of Reproductive Medicine, Department Histology Embryology, Nanjing Medical University, Nanjing, China Reproduction, Obstetrics Gynecology Hospital Affiliated to Search more papers by this author Cheng Zhou Ying Wang Weixiao Liu Stem Cell Biology, Institute Zoology, the Chinese Academy...
High reproductive compatibility between crops and their wild relatives can provide benefits for crop breeding but also poses risks agricultural weed evolution. Weedy rice is a feral relative of that infests paddies causes severe losses worldwide. In regions tropical Asia where the progenitor occurs, weedy could be influenced by hybridization with species. Genomic analysis this phenomenon has been very limited. Here we use whole genome sequence analyses 217 wild, cultivated samples to show...
Panax L. is a medicinally important genus within family Araliaceae, where almost all species are of cultural significance for traditional Chinese medicine. Previous studies suggested two independent origins the East Asia and North America disjunct distribution this multiple rounds whole genome duplications (WGDs) might have occurred during evolutionary process. We employed chloroplast nuclear markers to investigate evolution diversification Panax. Our phylogenetic analyses confirmed previous...
Panax L. (the ginseng genus) is a shade-demanding group within the family Araliaceae and all of its species are crucial significance in traditional Chinese medicine. Phylogenetic biogeographic analyses demonstrated that two rounds whole genome duplications accompanying with geographic ecological isolations promoted diversification species. However, contributions cytoplasmic genomes to adaptive evolution remained largely uninvestigated. In this study, we sequenced chloroplast mitochondrial 11...
Abstract Aging has many effects on the female reproductive system, among which decreased oocyte quality and impaired embryo developmental potential are most important factors affecting fertility. However, mechanisms underlying aging not yet fully understood. Here, we selected normal reproductively mice constructed a protein expression profile of metaphase II (MII) oocytes from three age groups. A total 187 differentially expressed (DE) proteins were identified, bioinformatics analyses showed...
Aquaporins (AQPs) are a kind of transmembrane proteins that exist in various organs the human body. AQPs play an important role regulating water transport, lipid metabolism and glycolysis cells. Clear cell renal carcinoma (ccRCC) is common malignant tumor kidney, prognosis worse than other types cancer (RCC). The impact on ccRCC potential relationship between occurrence development demanded to be investigated. In this study, we first explored expression pattern by using Oncomine, UALCAN, HPA...
In this study, an effective method for preparation of bioactive galloylated procyanidin B2-3′-O-gallate (B2-3′-G) was first developed by incomplete depolymerization grape seed polymeric procyanidins (PPCs) using l-cysteine (Cys) in the presence citric acid. The structure–activity relationship B2-3′-G further evaluated vitro through establishing lipopolysaccharide (LPS)-induced inflammation RAW264.7 cells. results suggested that better protective effects against were attributed to its...
aims: to develop a mild and efficient synthetic method for the synthesis of dibenzo[a,g]carbazoles background: conventional methods usually include extending conjugate structure carbazole-based molecules. Recently, photoredox catalysis has been applied into these dibenzocarbazole compounds, however, existing still suffer vulnerabilities, such as addition noble metal catalysts, highly functionalized starting materials, salts, which could not give satisfaction from practical perspective....
Anthocyanin synthetase (ANS), a key enzyme in the final step of anthocyanin synthesis pathway, catalyzes conversion leucoanthocyanidins to anthocyanins. In this study, an ANS structural protein (TRINITY_DN18024_c0_g1) was found be associated with accumulation Acer pseudosieboldianum leaves, named ApsANS. Real-time quantitative fluorescence PCR analysis revealed that expression ApsANS significantly higher red-leaved (variant) than green-leaved (wild-type) strains, which consistent...
Calmodulin (CaM) family members play crucial roles in the response to various abiotic stresses. However, functions of CaMs drought stress maize are unclear. In this study, a CaM gene, ZmCaM2-1, was isolated from (Zea mays L.) inbred line B73. The coding sequence (CDS) ZmCaM2-1 450 bp with protein 149 aa which contains four EF-hand motifs. located cell nucleus and membrane, is able bind Ca2+. strongly induced by drought, NaCl, low-temperature treatments, except for abscisic acid (ABA)...
The results of earlier observational research on the relationships between usage non-steroidal anti-inflammatory medicines (NSAIDs) and risk benign prostatic hyperplasia (BPH) have been inconsistent. To assess these associations, we performed both univariable multivariable Mendelian randomization (MR) studies. Instrumental variables (IVs) associated with exposures at significance level (p < 5 × 10–6) were selected from a comprehensive meta-analysis conducted by United Kingdom Biobank (UKB)....
Taking the typical yellow soil in Guizhou as research object, four treatments were set up： no fertilization （CK）, single application of chemical fertilizer （NP）, 50% organic instead nitrogen [1/2（NPM）], and 100% （M）. The effects on carbon its active components, pool management index, enzyme activity, maize soybean yield studied order to provide theoretical basis for scientific quality improvement this area. results showed that replacement by significantly increased pH, （SOC）, total （TN）...
Drought stress is one of the important abiotic stresses that affects maize production. As an Ca2+ sensor, calmodulin-like proteins (CMLs) play key roles in plant growth, development, and response, but there are a limited number studies regarding CMLs response to drought stress. In this study, Calmodulin-like gene, namely ZmCML3, was isolated from (Zea mays L.). The coding sequence (CDS) ZmCML3 474 bp protein 158 aa which contains three EF-hand motifs. localized within nucleus plasma...
Neuroblastoma is the most common pediatric malignancy with heterogeneous clinical behaviors, ranging from spontaneous regression to aggressive progression. Many studies have identified aberrations related pathogenesis and prognosis, broadly classifying neuroblastoma patients into high- low-risk groups, but predicting tumor progression management of high-risk remains a big challenge. We integrate gene-level expression, array-based comparative genomic hybridization functional gene-interaction...
The ubiquitin-like, containing PHD and RING finger domains, 1 (UHRF1) protein recognizes DNA methylation histone modification plays a critical role in epigenetic regulation. Recently, UHRF1 was shown to have oocytes early embryos. Here, we reveal that maternal determines the quality of mouse oocytes. We generated oocyte-specific Uhrf1-knockout mice found females were sterile, few UHRF1-null embryos developed into blastocysts. had an increased incidence aneuploidy damage. In addition...