A5078204215- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Neural dynamics and brain function
- Suicide and Self-Harm Studies
- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- Smoking Behavior and Cessation
- Diet and metabolism studies
- Neuroscience and Music Perception
- Treatment of Major Depression
- Genetics and Neurodevelopmental Disorders
- Psychosomatic Disorders and Their Treatments
- Traditional Chinese Medicine Analysis
- Nerve injury and regeneration
- S100 Proteins and Annexins
- Gout, Hyperuricemia, Uric Acid
- Mental Health Treatment and Access
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
Beijing HuiLongGuan Hospital
2016-2025
Peking University
2016-2025
Gansu University of Traditional Chinese Medicine
2018-2025
École Nationale des Greffes
2025
Yale University
2022
Peking University First Hospital
2022
University of Tartu
2022
University of Maryland, Baltimore
2019-2022
Stellenbosch University
2020
Johns Hopkins University
2020
Aggrecan is responsible for the mechanical properties of cartilage. One earliest changes observed in arthritis depletion cartilage aggrecan due to increased proteolytic cleavage within interglobular domain. Two major sites have been identified this region at Asn<sup>341</sup>-Phe<sup>342</sup> and Glu<sup>373</sup>-Ala<sup>374</sup>. While several matrix metalloproteinases shown cleave Asn<sup>341</sup>-Phe<sup>342</sup>, an as yet unidentified protein termed "aggrecanase"...
A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines data from many institutions worldwide. However, introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether batch adjustment method, ComBat, can further reduce site-related...
Presenilins are integral membrane protein involved in the production of amyloid β-protein. Mutations presenilin-1 and -2 gene associated with familial Alzheimer's disease thought to alter γ-secretase cleavage β-amyloid precursor protein, leading increased longer more amyloidogenic forms Aβ, 4-kDa β-peptide. Here, we show that radiolabeled inhibitors bind mammalian cell membranes, a benzophenone analog specifically photocross-links three major polypeptides. A positive correlation is observed...
Time-dependent increases in cue-induced nicotine and methamphetamine craving during abstinence were recently reported human drug-dependent individuals. In the present study, we sought to determine whether this 'incubation of craving' phenomenon also occurs alcoholics. Four groups 80 inpatient adult male alcoholics assessed a single session (between-group design) for alcohol at 7, 14, 30 60 days abstinence. Another group that included 19 patients was repeatedly tested same as above. Other...
Background: The pandemic of COVID-19 posed an unprecedented threat and cascade challenges to the general public in China, especially outbreak-affected severely city, Wuhan. psychological impact response epidemic disasters as well predisposing factors analysis are desperately needed. Methods: Self-administered questionnaires were distributed online population different regions from January 30 February 13, 2020.The Self-Reporting Questionnaire-20, Patient Health Questionnaire-9 Generalized...
The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on gut microbiota MDD are inconsistent, data MDD's effects sleep lacking. This study aimed to analyze composition quality patients with MDD. We performed 16S rRNA sequencing stool samples from 36 45 healthy controls (HC). Sleep was assessed using Pittsburgh Quality Index, severity Hamilton Depression Scale, insomnia Insomnia Severity...
Depression is characterized by pervasive cognitive and emotional disturbances, yet the neural mechanisms underlying these deficits remain incompletely understood. This study utilized multimodal neuroimaging, including resting-state functional MRI structural T1-weighted imaging, alongside MATRICS Consensus Cognitive Battery (MCCB) Hamilton Rating Scale (HAMD), to delineate alterations in insula first-episode, medication-naïve patients with depression. Compared matched healthy controls,...
Objective: Diagnosis of schizophrenia is currently dependent on symptom-based criteria and lacks objective indicators. In this study, the authors investigated whether circulating miRNA can serve as a diagnostic biomarker for schizophrenia. Methods: Global plasma miRNAs were profiled in test cohort 164 patients 187 control subjects, using Solexa sequencing, TaqMan Low Density Array, quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays. The captured then validated by...
Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct of structures involved the presumed peripheral-central interaction still unclear. Seventy-nine previously treatment-naïve first-episode patients who were within 2-week antipsychotics initial stabilization, and 41 age- sex-matched healthy controls enrolled study. Group differences subcortical regional measured by MRI subclinical cardiovascular,...
Failure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes resistance are unknown, but it associated earlier age at onset and more severe cognitive deficits. authors tested the hypothesis white matter deficits involved both neurodevelopment severity higher risk resistance.The study sample (N=122; mean age, 38.2 years) included initiation (N=45), whose were responsive (N=40), resistant...
Abstract Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer’s disease (AD). Both SZ and AD have white matter abnormalities cognitive deficits as core features. We hypothesized that aging in patients may be the development of cerebral deficit patterns similar to those observed AD. identified replicated aging-related increases similarity between The “regional vulnerability index” (RVI) was significantly higher compared healthy controls...
Abstract Cognitive impairment is a core characteristic of schizophrenia, but its underlying neural mechanisms remain poorly understood. Reduced brain-derived neurotrophic factor (BDNF), protein critical for plasticity and synaptic signaling, one the few molecules consistently associated with cognitive deficits in schizophrenia although etiological pathway leading to BDNF reduction unclear. We examined microRNA-195 (miR-195), known modulator expression, as potential mechanistic component....
Various azido-ubiquinone derivatives were synthesized and characterized.3-Azido-2-methyl-5-methoxy -6 -(3,7dimethyloctyl) -1,4 -benzoquinone was found to be suitable for the study of specific interaction between ubiquinone (Q) protein.It with high radioactivity used identify Q-binding proteins in purified ubiquinol-cytochrome c reductase.This azido-Q derivative showed partial efficiency restoring activity Q-and phospholipids-depleted reductase absence light.Azido-Q treated samples, however,...
To investigate the association between level of serum brain-derived neurotrophic factor (sBDNF) and therapeutic efficacy modified electroconvulsive therapy (MECT) in Chinese patients with depressive disorder.Twenty-eight episode 28 healthy subjects were recruited current study. The sBDNF was examined all before treatment after a 2-week MECT depression. severity depression measured according to 17-item Hamilton Rating Scale for Depression depression.The reduced significantly (31.39 [SD, 4.65]...
Clinical studies have shown that bipolar patients increased serum uric acid levels. High levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome is known increase the risk developing number life threatening diseases including coronary heart disease, hypertension, and type 2 diabetes. This study investigated association between hyperuricemia its components in individuals suffering from disorders. recruited 318 inpatients disorders Beijing...