A5101445261- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Child Abuse and Trauma
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Photocatalysis Techniques
- Autoimmune Neurological Disorders and Treatments
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Suicide and Self-Harm Studies
- Muscle Physiology and Disorders
- Sepsis Diagnosis and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Extracellular vesicles in disease
- Intensive Care Unit Cognitive Disorders
- MXene and MAX Phase Materials
- Hydrogen Storage and Materials
- Psychosomatic Disorders and Their Treatments
- Bipolar Disorder and Treatment
Peking University
2019-2025
Beijing HuiLongGuan Hospital
2019-2025
Shanghai Tenth People's Hospital
2024-2025
Tongji University
2024-2025
First People's Hospital of Yunnan Province
2024
Xian Central Hospital
2024
Xiaomi (China)
2024
Ningbo University
2020-2022
Yale University
2022
Peking University First Hospital
2022
Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct of structures involved the presumed peripheral-central interaction still unclear. Seventy-nine previously treatment-naïve first-episode patients who were within 2-week antipsychotics initial stabilization, and 41 age- sex-matched healthy controls enrolled study. Group differences subcortical regional measured by MRI subclinical cardiovascular,...
Failure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes resistance are unknown, but it associated earlier age at onset and more severe cognitive deficits. authors tested the hypothesis white matter deficits involved both neurodevelopment severity higher risk resistance.The study sample (N=122; mean age, 38.2 years) included initiation (N=45), whose were responsive (N=40), resistant...
Novel polyimide-epoxy organic–inorganic nanocomposites are prepared by in situ curing of polyamic acid macromolecules with two POSS epoxides, octa[(epoxycyclohexylethyl)dimethylsilyloxy]silsesquioxane (OC) and octa[(epoxyhexyl)dimethylsilyloxy]silsesquioxane (OH). Comparison between series from OC OH provides a typical example controlling the macro-scale properties adjusting nano-tether structure molecules. DMA studies conclude that crosslink densities increase significantly; nanocomposite...
Abstract Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white integrity. We proposed the regional vulnerability index (RVI) to translate results Enhancing Neuro Imaging Genetics Meta‐Analysis studies individual level. calculated RVIs for cortical, subcortical, measurements a multimodality RVI. evaluated RVI as measure sensitive schizophrenia‐specific neuroanatomical symptoms studied timeline...
Abstract Cognitive impairment is a core characteristic of schizophrenia, but its underlying neural mechanisms remain poorly understood. Reduced brain-derived neurotrophic factor (BDNF), protein critical for plasticity and synaptic signaling, one the few molecules consistently associated with cognitive deficits in schizophrenia although etiological pathway leading to BDNF reduction unclear. We examined microRNA-195 (miR-195), known modulator expression, as potential mechanistic component....
Low-grade neural and peripheral inflammation are among the proposed pathophysiological mechanisms of schizophrenia. White matter impairment is one more consistent findings in schizophrenia but underlying mechanism remains obscure. Many cerebral white components sensitive to neuroinflammatory conditions that can result demyelination, altered oligodendrocyte differentiation, other changes. We tested hypothesis immune-inflammatory response system (IRS) compensatory immune-regulatory reflex...
A dysfunctional default mode network (DMN) has been reported in patients with schizophrenia. However, the stability of deficits not determined across different stages disorder.We examined functional connectivity DMN subsystems 125 first-episode schizophrenia (FES) or recurrent (RES), compared to that 82 healthy controls. We tested robustness findings an independent cohort 158 and 39 performed resting-state analysis, strength connections within between three (core, dorsal medial prefrontal...
Abstract Denervated muscle atrophy, a common outcome of nerve injury, often results in irreversible fibrosis due to the limited effectiveness current therapeutic interventions. While extracellular vesicles (EVs) offer promise for treating their potential is hindered by challenges delivery and bioactivity within complex microenvironment injury site. To address this issue, an injectable hydrogel developed that responsive both ultrasound pH, with inherent anti‐inflammatory antioxidant...
To investigate the role of mitochondrial ribosomal proteins (MRPs) in pathogenesis and progression septic myocardial injury. Additionally, we aim to propose new technical strategies experimental foundations for prevention treatment Animal cell models injury were established. Aberrantly expressed MRPs screened using transcriptome sequencing, their expression was verified by RT-qPCR Western blot. Subsequently, overexpressed knockdown constructed. The effects on CO I, PGC-1α, ATP content, ROS...
Abstract Objective This study aims to evaluate the clinical efficacy of endoscopic plantar fascia release through modified dual medial deep approach for treatment refractory fasciitis. Methods A retrospective was conducted involving 34 patients with fasciitis treated by approach. Among them, 25 had concurrent calcaneal spurs. All were followed a minimum 12 months. Functional outcomes assessed using Visual Analogue Scale (VAS) and American Orthopaedic Foot Ankle Society (AOFAS) score, while...
A series of nano-hybrid light emitting dots with diameter range from 2 nm to 4 were synthesized through grafting organic conjugated chains directly onto an inorganic rigid cage polyhedral oligomeric silsesquioxanes (POSS). The effect chain length, side groups, polarity solvents on the property studied using FTIR, XRD, DSC, UV, PL, AFM and SEM. unique structure these renders them excellent PL properties which are much different bulk molecules or polymers. incorporation POSS transforms...
Abstract Objective To determine whether suicidal ideation or suicide attempts are linked to poor neurocognitive function among individuals with first‐episode schizophrenia (FES). Method We performed a cross‐sectional study on 159 Chinese inpatients ( M age = 27.1 years; 52.2% females) minimal‐treated FES and collected their history through interviews medical records. Neurocognitive performance, psychopathology, depressive symptoms were assessed using the MATRICS Consensus Cognitive Battery,...
Soluble low-molecular-weight oligomers formed during the early stage of amyloid aggregation are considered major toxic species in amyloidosis. The structure-function relationship between oligomeric assemblies and cytotoxicity diseases still elusive due to heterogeneous transient nature these intermediates. To uncover structural characteristics intermediates, we compared self-assembly dynamics structures SOD128-38, a cytotoxic fragment superoxide dismutase 1 (SOD1) associated with amyotrophic...
Approximately a third of patients with schizophrenia fail to adequately respond antipsychotic medications, condition known as treatment resistance (TR). We aimed assess cognitive and cortical thickness deficits their relationship TR in schizophrenia.
Abstract Insufficient or lack of response to antipsychotic medications in some patients with schizophrenia is a major challenge psychiatry, but the underlying mechanisms remain unclear. Two seemingly unrelated observations, cerebral white matter and N-methyl-D-aspartate receptor (NMDAR) hypofunction, have been linked treatment-resistant (TRS). As NMDARs are critical axonal myelination signal transduction, we hypothesized that NMDAR antibody (Ab), when present schizophrenia, may impair...
Several studies have indicated that the platelet-derived growth factor/platelet-derived factor receptor (PDGF/PDGFR) pathway is involved in process of atherosclerosis. However, its underlying mechanism remains to be further elucidated. Serine/threonine-protein kinase pim-1 (Pim-1), a member serine/threonine-specific kinases, pro-oncogene published related cell proliferation, apoptosis, and metastasis cancer cells. Whether Pim-1 PDGF/PDGFR pathway-mediated coronary atherosclerotic heart...
The electrocatalytic nitrogen reduction reaction (NRR) is considered to be the most desirable strategy for ammonia production but still faces many challenges in terms of high activity and selectivity. Based on density functional theory (DFT) calculations, catalytic performance a series (3d, 4d 5d series) transition metals atoms (TMs) anchored novel graphitic carbon-nitrogen (g-C9N4) monolayer has been systematically investigated. We find that TMs can bind tightly g-C9N4 form single-atom...
Reduced cortical gray matter integrity and cognitive abilities are among core deficits in schizophrenia. We hypothesized that higher allostatic load (AL) accounts for exposure to chronic stress is a contributor structural One hundred sixty-seven schizophrenia patients who were on average with normal weight, systolic, diastolic blood pressure 72 healthy controls enrolled the study. Group differences subclinical cardiovascular, metabolic, immune, neuroendocrine biological markers as indexed by...