A5066922905- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Bipolar Disorder and Treatment
- Neuroscience and Music Perception
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Intergenerational Family Dynamics and Caregiving
- Sleep and Wakefulness Research
- Demographic Trends and Gender Preferences
- Health disparities and outcomes
- Folate and B Vitamins Research
- Prosthetics and Rehabilitation Robotics
- Genomics and Rare Diseases
- Obsessive-Compulsive Spectrum Disorders
- China's Socioeconomic Reforms and Governance
Weifang People's Hospital
2025
Second Hospital of Shandong University
2024-2025
Tianjin Medical University General Hospital
2023-2025
Shandong University of Traditional Chinese Medicine
2024-2025
Yuhuangding Hospital
2025
Qingdao University
2025
Hubei Cancer Hospital
2025
Peking University Sixth Hospital
2015-2024
Peking University
2015-2024
Jiangnan University
2024
Current fMRI-based classification approaches mostly use functional connectivity or spatial maps as input, instead of exploring the dynamic time courses directly, which does not leverage full temporal information.Motivated by ability recurrent neural networks (RNN) in capturing information sequences, we propose a multi-scale RNN model, enables between 558 schizophrenia and 542 healthy controls using fMRI independent components (ICs) directly. To increase interpretability, also...
Past work on relatively small, single-site studies using regional volumetry, and more recently machine learning methods, has shown that widespread structural brain abnormalities are prominent in schizophrenia. However, to be clinically useful, imaging biomarkers must integrate high-dimensional data provide reproducible results across clinical populations an individual person basis. Using advanced multi-variate analysis tools pooled from case–control conducted at 5 sites (941 adult...
Previously, we reported that α1,6-fucosyltransferase (Fut8)-deficient (Fut8−/−) mice exhibit emphysema-like changes in the lung and severe growth retardation due to dysregulation of TGF-β1 EGF receptors abnormal integrin activation, respectively. To study role α1,6-fucosylation brain tissue where Fut8 is highly expressed, examined Fut8−/− using a combination neurological behavioral tests. exhibited multiple abnormalities consistent with schizophrenia-like phenotype. displayed increased...
Introduction Current pathophysiological theories of schizophrenia highlight the role altered brain functional and anatomical connectivity. The cognitive division anterior cingulate cortex (ACC-cd) is a commonly reported abnormal region in for its importance control process. aim this study was to investigate connectivity ACC-cd clinical manifestation significance by using resting-state magnetic resonance imaging (fMRI) diffusion tensor (DTI). Methods Thirty-three medicated schizophrenics 30...
Background Auditory verbal hallucinations (AVHs) are one of the most common and severe symptoms schizophrenia, but neuroanatomical abnormalities underlying AVHs not well understood. The present study aims to investigate whether associated with cortical thinning. Methods Participants were schizophrenia patients from four centers across China, 115 93 without AVHs, as 261 healthy controls. All received 3 T T1-weighted brain scans, whole vertex-wise thickness was compared groups. Correlations...
Choosing the appropriate antipsychotic drug (APD) treatment for patients with schizophrenia (SCZ) can be challenging, as response to APD is highly variable and difficult predict due lack of effective biomarkers. Previous studies have indicated association between genetic epigenetic factors, but no biomarkers been identified. Hence, further research imperative enhance precision medicine in SCZ treatment.Participants were recruited from two randomized trials. The discovery cohort was CAPOC...
In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1 * 15:01 ‐ DQA1 01:02 DQB1 06:02 haplotype. Studies in African‐Americans suggest a primary effect of , but this observation has been difficult to confirm other populations because high linkage disequilibrium between 15:01/3 most populations. study, we studied human leucocyte antigen ( HLA ) class II 202 Chinese narcolepsy patients (11% from South China) found all be positive. Comparing...
Multimodal fusion has been regarded as a promising tool to discover covarying patterns of multiple imaging types impaired in brain diseases, such schizophrenia (SZ). In this article, we aim investigate the abnormalities underlying SZ large Chinese Han population (307 SZs, 298 healthy controls [HCs]). Four magnetic resonance (MRI) features, including regional homogeneity (ReHo) from resting-state functional MRI, gray matter volume (GM) structural fractional anisotropy (FA) diffusion and...
Significance Air pollution is ubiquitous and may increase neuropsychiatric risk, including for depression. However, the neural underpinnings whether this environmental risk acts independently or interactively with genetic mechanisms are not well understood. In healthy individuals exposed to significant air pollution, we find that combined high exposures relatively polygenic depression disproportionately augmented stress-related effects on brain circuitry. The coexpression of...
Background: Prior studies have separately demonstrated that magnetic resonance imaging (MRI) and schizophrenia polygenic risk score (PRS) are predictive of antipsychotic medication treatment outcomes in schizophrenia. However, it remains unclear whether MRI combined with PRS can provide superior prognostic performance. Besides, the relative importance these measures predictions is not investigated. Methods: We collected 57 patients schizophrenia, all which had baseline genotype data. All...
Limited evidence supports multigenetic pharmacogenomics-guided treatment (MPGT) in schizophrenia.To evaluate the clinical effectiveness of MPGT schizophrenia a randomized trial (RCT).This RCT was conducted from March 2020 to 2022. Male Chinese Han inpatients aged 18 60 years diagnosed with Positive and Negative Symptom Scale (PANSS) score or more 2 selected study hospitals were included. Patients raters masked as usual (TAU) randomization.Participants randomly assigned 1:1 ratio receive...
Abstract To elucidate the brain‐wide information interactions that vary and contribute to individual differences in schizophrenia (SCZ), an information‐resolved method is employed construct synergistic redundant interaction matrices based on regional pairwise BOLD time‐series from 538 SCZ 540 normal controls (NC). This analysis reveals a stable pattern of regionally‐specific synergy dysfunction SCZ. Furthermore, hierarchical Bayesian model applied deconstruct patterns whole‐brain into three...
Abstract Human ENGRAILED 2 ( EN2 ) gene is localized to 7q36, an autism susceptibility locus. En2 knockout mice display hypoplasia of cerebellum and a decrease in the number Purkinje cell, which are similar those reported for individuals with autism. Furthermore, deficits social behavior were detected −/− mice. Two recent studies have demonstrated that two intronic SNPs (rs1861972, rs1861973) significantly associated To investigate whether this finding could be replicated Chinese Han...
The underlying mechanism for individual differences in patient response to antipsychotic medication remains unknown.To discover genes and gene sets harboring rare variants associated with short-term efficacy.In this multicenter, open-label, randomized clinical trial conducted between July 6, 2010, December 31, 2011, 3023 patients recruited China of Chinese Han descent schizophrenia total Positive Negative Syndrome Scale (PANSS) score ≥ 60 received a 6-week treatment medications randomly...
Background Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure function are plausible neurobiological characterisation schizophrenia. However, the effects schizophrenia on these imaging endophenotypes not yet been fully elucidated. Aims To investigate risk for grey matter volume functional connectivity, which disrupted in Method Genomic data from large sample Han...
Background Shared neuropathological features between schizophrenic patients and their first-degree relatives have potential as indicators of genetic vulnerability to schizophrenia. We sought explore influences on brain morphology function in relatives. Methods Using a multimodal imaging strategy, we studied 33 patients, 55 unaffected parents, 30 healthy controls for 29 parents with voxel-based morphometry structural MRI scans functional connectivity analysis resting-state data. Results...