A5100742540- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Protein Hydrolysis and Bioactive Peptides
- Meat and Animal Product Quality
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Aortic Disease and Treatment Approaches
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Polyamine Metabolism and Applications
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Axon Guidance and Neuronal Signaling
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- Cellular transport and secretion
- Connective tissue disorders research
- Adenosine and Purinergic Signaling
- Metabolomics and Mass Spectrometry Studies
Jiangmen Central Hospital
2025
Shandong First Medical University
2024-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019-2025
Wenzhou Medical University
2019-2025
West China Hospital of Sichuan University
2016-2025
Sichuan University
2015-2025
Shaoguan University
2025
First Affiliated Hospital of Gannan Medical University
2021-2024
Zhejiang Institute of Communications
2022-2024
Wenzhou Hospital of Traditional Chinese Medicine
2022-2024
Major depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum (LS) is thought to control depression, however, cellular circuit substrates largely unknown. Here, we identified subpopulation LS GABAergic adenosine A
Hypoxic-ischemic encephalopathy (HIE) is a brain damage caused by perinatal hypoxia and blood flow reduction. Severe HIE leads to death. Available treatments remain limited. Oxidative stress nerve are major factors in injury HIE. Catalpol, an iridoid glucoside found the root of Rehmannia glutinosa, has antioxidant neuroprotective effects. This study examined effects catalpol using neonatal rat model that might protect through inhibiting neuronal ferroptosis ameliorating oxidative stress....
Abstract The foundation model, trained on extensive and diverse datasets, has shown strong performance across numerous downstream tasks. Nevertheless, its application in the medical domain is significantly hindered by issues such as data volume, heterogeneity, privacy concerns. Therefore, we propose Vision Foundation Model General Lightweight (VFMGL) framework, which facilitates decentralized construction of expert clinical models for various VFMGL framework transfers general knowledge from...
Background Auditory verbal hallucinations (AVHs) are one of the most common and severe symptoms schizophrenia, but neuroanatomical abnormalities underlying AVHs not well understood. The present study aims to investigate whether associated with cortical thinning. Methods Participants were schizophrenia patients from four centers across China, 115 93 without AVHs, as 261 healthy controls. All received 3 T T1-weighted brain scans, whole vertex-wise thickness was compared groups. Correlations...
Hypoxic-ischemic encephalopathy (HIE) is recognized as the main cause of neonatal death, and efficient treatment strategies remain limited. Given prevalence HIE associated fatality, further studies on its pathogenesis are warranted. Oxidative stress neuroinflammatory injury two important factors leading to brain tissue nerve cell loss in HIE. Neferine, an alkaloid extracted from lotus seed embryo, exerts considerable effects against several diseases such cancers myocardial injury. In this...
Abstract Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, has become an important global burden disease. Transurethral plasmakinetic resection prostate (TUPKP) one the foremost surgical procedures for treatment BPH. It well established in clinical practice with good efficacy safety. In 2018, we issued guideline “2018 Standard Edition”. However much new direct evidence now emerged this may...
Hypoxic-ischemic encephalopathy (HIE) is detrimental to newborns and associated with high mortality poor prognosis. Thus, the primary aim of present study was determine whether glycine could (1) attenuate HIE injury in rats hypoxic stress PC12 cells (2) downregulate mitochondria-mediated autophagy dependent on adenosine monophosphate- (AMP-) activated protein kinase (AMPK) pathway. Experiments conducted using an vivo animal model vitro revealed that intense mitochondrial function occurred...
Neonatal hypoxic-ischemic (HI) brain injury can lead to mortality and severe long-term disabilities including cerebral palsy injury.
The cellular and molecular mechanisms that govern the response of perinatal brain to injury remain largely unexplored. We investigated role white matter astrocytes in a rodent model diffuse produced by exposing neonatal mice chronic hypoxia—a paradigm mimics premature infants. demonstrate absence reactive gliosis immature following hypoxia, as determined astrocyte proliferation index glial fibrillary acidic protein levels. Instead, Nestin expression is transiently increased, glial-specific...
The medial subnucleus of the amygdala (MeA) plays a central role in processing sensory cues required for innate behaviors. However, whether there is link between developmental programs and emergence inborn behaviors remains unknown. Our previous studies revealed that telencephalic preoptic area (POA) embryonic niche novel source MeA destined progenitors. Here, we show POA comprised distinct progenitor pools complementarily marked by transcription factors Dbx1 Foxp2. As determined molecular...
// Mingchu Fang 1 , Huai Jiang Lixia Ye Chenchen Cai Yingying Hu Shulin Pan Peijun Li 2 Jian Xiao 3 and Zhenlang Lin Department of Neonatology, The Second Affiliated Hospital Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China Center for Neuroscience Research, National Health System, Washington, DC 20010, United States Molecular Pharmacology Research Center, School Pharmacy, 325035, Correspondence to: Xiao, email: xfxj2000@126.com Lin,...
MicroRNAs (miRNAs) are important gene regulators in both biological and pathological processes, including myocardial ischemia/reperfusion (I/R) injury. This study investigated the effect of miR-613 on I/R-induced cardiomyocyte apoptosis its molecular mechanism action. Hypoxia/reoxygenation (H/R) significantly increased release lactate dehydrogenase (LDH), levels malondialdehyde (MDA), apoptosis, but these effects were attenuated by an mimic. Programmed cell death 10 (PDCD10) was identified...