A5040830735- Receptor Mechanisms and Signaling
- Radiopharmaceutical Chemistry and Applications
- Mathematical and Theoretical Epidemiology and Ecology Models
- Nicotinic Acetylcholine Receptors Study
- Medical Imaging Techniques and Applications
- Evolution and Genetic Dynamics
- Uterine Myomas and Treatments
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Adenosine and Purinergic Signaling
- Advanced MRI Techniques and Applications
- Mathematical Biology Tumor Growth
- Endometriosis Research and Treatment
- Mast cells and histamine
- GaN-based semiconductor devices and materials
- Microbial Natural Products and Biosynthesis
- Pharmacological Receptor Mechanisms and Effects
- Click Chemistry and Applications
- Cancer-related Molecular Pathways
- Neonatal and fetal brain pathology
- Endometrial and Cervical Cancer Treatments
- Ubiquitin and proteasome pathways
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
Tokyo Medical University
2014-2025
Niigata University of Health and Welfare
2025
Kanazawa Medical University Hospital
2025
Okayama University
2006-2024
Japan Organization of Occupational Health and Safety
2011-2024
Juntendo University Nerima Hospital
2023
Children's National
2018-2022
Jichi Medical University
2017-2022
Ashiya University
2022
Sanofi (Japan)
2017-2019
Dsk2p from Saccharomyces cerevisiae belongs to the class of proteins that contain a ubiquitin-like (UbL) domain at N terminus together with ubiquitin-associated (UBA) C terminus. We show here C-terminal UBA binds K48-linked polyubiquitin chains, and N-terminal UbL interacts proteasome. Overexpression caused accumulation large amounts polyubiquitin, extragenic suppressors Dsk2p-mediated lethality proved be temperature-sensitive mutations in two proteasome subunits, rpn1 pre2....
Gallium-nitride single crystals were grown on (0001)- and (011̄2)-oriented sapphire substrates by metalorganic vapor-phase epitaxy. Smooth-surfaced layers with fine ridgelike facets can be obtained the (011̄2) sapphire. They have lower carrier concentrations than (0001) Deep centers responsible for blue (∼425 nm) yellow (∼560 emissions from undoped are reduced substrates, as compared substrates. On other hand, better crystallinity higher Zn-incorporation efficiency those Growth kinetics of...
Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABAAR) modulator, reduction alters neurodevelopment in sex-linked manner. A new conditional mouse model, which the gene encoding ALLO's synthetic enzyme (akr1c14) is specifically deleted trophoblasts, directly demonstrated ALLO insufficiency led cerebellar white matter abnormalities correlated...
Itai-itai disease is the most severe case of chronic cadmium (Cd) toxicity, which was endemic in Cd-polluted areas Jinzu River basin Toyama prefecture, Japan. Akita prefecture also has areas, but there have been no cases "itai-itai disease".
An important and exciting challenge in the postgenomic era is to understand functions of newly discovered proteins based on their structures. The main thrust find common structural motifs that contribute specific functions. Using this premise, here we report purification, solution NMR, functional characterization a novel class weak potassium channel toxins from venom scorpion <i>Heterometrus fulvipes</i>. These toxins, κ-hefutoxin1 κ-hefutoxin2, exhibit no homology any known toxins. NMR...
In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which acetylation is regulated still unclear. Here, we describe an essential role HLA-B-associated transcript 3 (Bat3)/Scythe in controlling of required damage responses. Depletion Bat3 from human and mouse cells markedly impairs p53-mediated transactivation target genes Puma p21 . Although damage-induced...
Abstract Aim Although there are various hormone therapies, including gonadotropin‐releasing agonist, danazol, levonorgestrel‐releasing intrauterine system, dienogest, and low‐dose estrogen progestin, no consensus opinion has been reached in terms of which medication should be used for how long it administered. We aimed to determine whether dienogest or goserelin is the better postoperative therapy prevent recurrence endometriosis. Methods A prospective cohort randomized study were conducted,...
MicroRNA (miRNA) expression is altered in cancer cells and associated with the development progression of various types cancer. Accordingly, miRNAs may serve as diagnostic or prognostic biomarkers patients. In this study, we attempted to analyze circulating exosomal miRNA patients cervical Total RNA was extracted from serum healthy subjects, subjects intraepithelial neoplasia (CIN) We first investigated profiles 6 samples using miRCURY LNA microRNA array. significant differences were...
Understanding the substrate recognition mechanism of γ-secretase is a key step for establishing substrate-specific inhibition amyloid β-protein (Aβ) production. However, it widely believed that promiscuous protease and its elusive. Here we show distinguishes ectodomain length substrates preferentially captures cleaves containing short ectodomain. We also subset peptides CDCYCxxxxCxCxSC motif binds to amino terminus C99 inhibits Aβ production in manner. Interestingly, these suppress...
Meiosis is critical for sexual reproduction. During meiosis, the dynamics and integrity of homologous chromosomes are tightly regulated. The genetic molecular mechanisms governing these processes in vivo, however, remain largely unknown. In this study, we demonstrate that Bat3/Scythe essential survival maintenance male germ cells (GCs). Targeted inactivation mice results widespread apoptosis meiotic GCs complete infertility. Pachytene spermatocytes exhibit abnormal assembly disassembly...
Aflibercept targets vascular endothelial growth factor. The present study involved assessing the efficacy, safety and pharmacokinetics of aflibercept plus 5‐fluorouracil/levofolinate/irinotecan ( FOLFIRI ) as a second‐line treatment for metastatic colorectal cancer mCRC in Japanese patients. (4 mg/kg) was administered every 2 weeks 62 patients with until disease progression, unacceptable toxicity or patient withdrawal. Tumors were imaged 6 weeks. primary endpoint objective response rate ORR...