A5101897192- Renal Transplantation Outcomes and Treatments
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Cancer-related Molecular Pathways
- Advanced Measurement and Detection Methods
- RNA modifications and cancer
- Advanced Measurement and Metrology Techniques
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Advanced Surface Polishing Techniques
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Renal Diseases and Glomerulopathies
- Optical measurement and interference techniques
- Neurological Complications and Syndromes
- RNA Research and Splicing
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- T-cell and B-cell Immunology
- Diabetes and associated disorders
Shanghai First People's Hospital
2014-2025
Shanghai Jiao Tong University
2014-2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2004-2025
Zhejiang Taizhou Hospital
2024
Wenzhou Medical University
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2012-2024
Tang Du Hospital
2022-2023
Air Force Medical University
2009-2023
Mesenchymal stem cells (MSCs) derived exosomes have been shown to protective effects on the kidney in ischemia/reperfusion-induced renal injury. However, key components and their potential mechanisms for are not well understood. In our current study, we focused abundant proteins from MSCs (MSC-exo) found that C-C motif chemokine receptor-2 (CCR2) was expressed MSC-exo with a high ability bind its ligand CCL2. We also proved CCR2 high-expressed could reduce concentration of free CCL2 suppress...
Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes, such as transcriptional regulation, cell growth and tumorigenesis. However, little is known about whether lncRNA-GAS5 (growth arrest-specific 5) regulates bladder cancer progression. In the present study, we found that GAS5 expression commonly downregulated lines human specimens. Knockdown of promotes proliferation, whereas forced suppresses proliferation. We further demonstrated knockdown increases CDK6...
Long noncoding RNAs have been shown to important regulatory roles in cancer biology, and long RNA 19 (H19) is essential for human tumor growth. However, little known about how abnormal expression of H19 contributes bladder cell proliferation. In this study, we first evaluated the tissues by real-time PCR, defined biological functions. We found that levels were remarkably increased as compared with adjacent normal control tissue, forced promoted proliferation vitro. Inhibitor DNA...
HLA-G is a potentially interesting molecule associated with immunosuppressive function. We survey here the presence of soluble (sHLA-G) in serial serum samples renal transplants. A total 330 sera from 65 patients were tested for sHLA-G ELISA. IgG/IgM antibodies to HLA, and MICA also previously tested. After analysis patients' sera, 50% 26 functioning group had consistent expression or became positive, comparison 20.5% among 39 who rejected their transplants (p=0.013). Thus was Eighty percent...
Abstract Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, has become an important global burden disease. Transurethral plasmakinetic resection prostate (TUPKP) one the foremost surgical procedures for treatment BPH. It well established in clinical practice with good efficacy safety. In 2018, we issued guideline “2018 Standard Edition”. However much new direct evidence now emerged this may...
Although patients positive for HIV were once thought to be unsuitable candidates kidney transplantation, their increasing numbers with end-stage renal disease (ESRD) and the introduction of highly active antiretroviral therapy has indicated that they should no longer excluded transplantation. To counteract suggestions human immunodeficiency virus (HIV) received suboptimal kidneys, we provide studies kidneys transplanted from same donor into without HIV.United Network Organ Sharing transplant...
// Jun Wang 1 , Ping Zhang 2 Jie Zhong Mingyue Tan Jifu Ge Le Tao Yakui Li Yemin Zhu Lifang Wu Jianxin Qiu and Xuemei Tong Department of Urology, Shanghai General Hospital, Jiao University School Medicine, Shanghai, China Biochemistry Molecular Cell Biology, Key Laboratory for Tumor Microenvironment Inflammation, Correspondence to: Tong, email: Qiu, Keywords : PFKP, aerobic glycolysis, proliferation, clear cell renal carcinoma Received September 06, 2015 Accepted March 14, 2016 Published 25,...
With the development of single DP-antigen beads, antibodies to DP could clearly be segregated from other HLA antibodies. We studied 323 sera patients four different centers with functioning or rejected kidney grafts. were found in 5.1% 138 grafts, and 19.5 % 185 grafts (P<0.001)). 42.9% 63.9% antibody positive had DR/DQ among group. Among who did not have Class I antibodies, 13% those a graft compared 3.5% (P<0.05). 0301 highest specificity frequency In conclusion, HLA-DP detected at higher...
Homeodomain-interacting protein kinase-2 (Hipk2) has been shown to have important regulatory roles in cancer biology, such as cell proliferation, cycle, and invasion. However, the contributions of Hipk2 bladder metastasis remain largely unknown. In current study, we assayed expression level tissues by real-time PCR, defined its biological functions. We found that levels were downregulated most compared with adjacent normal tissues, remarkably decreased metastasized tumor when primary tumors....
Abstract Bladder cancer (BC) is the most popular malignant urinary in China. BC has highest incidence and mortality among all genitourinary system tumors. Although early-stage could be treated with advanced electron flexible systourethroscope, early metastasis of occur frequently often results poor prognosis. Recently, we reported that small ubiquitin related modifier (SUMO)-specific protease 2 (SENP2) was downregulated specimen. SENP2 appeared to inhibit migration invasion bladder cells...
Regulator of cullins 1 (ROC1) is an important catalytic subunit cullin-RING E3 ligase. Nuclear factor-kappa B (NF-κB) signaling closely related to tumor invasion and metastasis. Earlier, we reported that ROC1 was associated with a poor prognosis in patients bladder cancer (BCa). However, it unclear whether involved the NF-κB malignant BCa progression.The expression p65 paracancerous tissues were detected by immunohistochemistry (IHC). Pearson correlation used assess between protein...
Background Primary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell (LCNEC) in past. Case description A 43-year-old non-smoking female patient presented with symptoms dysuria urination-related pain at TangDu Hospital April 2022. biopsy subsequently confirmed diagnosis primary urethral LCNEC. Following radical resection, exhibited abnormal lymph node enlargement first month pelvic metastases fourth month. Ultimately,...
Tacrolimus is one of the most commonly used basic immunosuppressants nowadays, but high variability tacrolimus blood concentration often leads to kidney transplant recipients frequently experiencing drug concentrations above or below target concentration, resulting in renal toxicity rejection transplanted kidney. The aim this study explore correlation function with intra-patient (IPV) among transplants at 1-, 3-, 5-, and 10-year post-transplantation. Recipients who were treated for...
The solute carrier family 16 member 1 (SLC16A1) gene demonstrates abnormally elevated expression levels in a variety of human malignant tumors, and it is pivotal tumor initiation progression. Nonetheless, the precise mechanisms through which this operates head neck squamous cell carcinoma (HNSCC) need to be elucidated. This study integrated bioinformatics analysis with clinical patient samples elucidate that mRNA protein SLC16A1 were significantly upregulated patients HNSCC, was closely...
Background: SUMO-specific protease 2 (SENP2) is a de-SUMOylation family member which has an indispensable role in the regulation of NF-κB transcriptional activation and Wnt signaling. However, whether SENP2 plays tumor metastasis completely unknown. Methods: Real-time PCR Western blot was used to detect expression human bladder cancer samples cell lines. Small interfering RNA (siRNA) silencing SENP2. Matrigel-coated invasion chambers were ability cells. Results: down-regulated samples....
Renal cell carcinoma (RCC), which is derived from the proximal tubules of nephrons, one most common solid cancers. Due to its inherent insensitivity radiotherapy and chemotherapy, surgery remains only curative strategy for RCC. Therefore, a novel treating RCC urgently needed. This study aims investigate effects dauricine, bisbenzylisoquinoline alkaloid, in cells underlying mechanisms action. The dauricine on viability, cycle distribution apoptosis were determined vitro by MTT assay, flow...
Abstract Background and Objective RING box protein‐1 (RBX1) is a key subunit of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F‐box protein complex. Altered expression RBX1 shown to associate with tumorigenesis tumor progression. This study detected for association clinical significance (such as clinicopathological data survival patients) in non‐muscle‐invasive bladder transitional cell carcinoma (NMIBC). Methods A total 70 primary NMIBC tissue specimens 24 normal were recruited analyzed...
SUMO‐specific protease 2 (SENP2) is a deSUMOylation that plays an important role in the regulation of transforming growth factor‐β (TGF‐β) signaling. Aberrant TGF‐β signaling common human cancers and contributes to tumor metastasis by inducing epithelial‐mesenchymal transition (EMT). In previous studies, we demonstrated SENP2 suppresses bladder cancer cell migration invasion. However, little known about whether inhibits EMT regulating progression. Here, investigated vitro vivo. We found...