A5062683178- Semiconductor materials and devices
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Advancements in Semiconductor Devices and Circuit Design
- RNA Interference and Gene Delivery
- Integrated Circuits and Semiconductor Failure Analysis
- Trace Elements in Health
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Transcranial Magnetic Stimulation Studies
- Cancer-related gene regulation
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- Ferroelectric and Negative Capacitance Devices
- Effects of Radiation Exposure
- Dendrimers and Hyperbranched Polymers
- Advanced Polymer Synthesis and Characterization
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Dementia and Cognitive Impairment Research
Shanghai Jiao Tong University
2015-2025
Shanghai First People's Hospital
2015-2025
Shanghai Mental Health Center
2019-2025
First Affiliated Hospital Zhejiang University
2025
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2023-2024
Affiliated Hospital of Shaanxi University of Chinese Medicine
2024
Shaanxi University of Chinese Medicine
2024
Central Hospital of Wuhan
2023
Institute of High Performance Computing
2018-2022
Methods: Our deep learning model, called AnatomyNet, segments OARs from head and neck CT images in an end-to-end fashion, receiving whole-volume HaN as input generating masks of all interest one shot. AnatomyNet is built upon the popular 3D U-net architecture, but extends it three important ways: 1) a new encoding scheme to allow auto-segmentation on instead local patches or subsets slices, 2) incorporating squeeze-and-excitation residual blocks layers for better feature representation, 3)...
Herein, we report a novel Janus particle and supramolecular block copolymer consisting of two chemically distinct hyperbranched polymers, which is coined as polymer. It constructed by the noncovalent coupling between hydrophobic poly(3-ethyl-3-oxetanemethanol) with an apex azobenzene (AZO) group hydrophilic polyglycerol β-cyclodextrin (CD) through specific AZO/CD host-guest interactions. Such amphiphilic polymer resembles tree together its root very well in architecture can further...
Delineating organs at risk (OARs) on computed tomography (CT) images is an essential step in radiation therapy; however, it notoriously time-consuming and prone to inter-observer variation. Herein, we report a deep learning-based automatic segmentation (AS) algorithm (WBNet) that can accurately efficiently delineate all major OARs the entire body directly CT scans.We collected 755 scans of head neck, thorax, abdomen, pelvis manually delineated 50 images. The with contours were split into...
Sleeping giants: As a mimic of cell agglomeration to form tissues, novel vesicle aggregation process with the characteristic advantages being highly efficient, light-responsive, reversible, large-scale, and stable is reported. Giant hyperbranched polymer vesicles (5–10 μm) are used as building blocks (see scheme), aggregates can assemble disassemble alternating UV Vis irradiation. Detailed facts importance specialist readers published "Supporting Information". Such documents peer-reviewed,...
Abstract The efficacy of radiation therapy (RT) is often limited by the poor response hypoxia inside most solid tumors. development a theranostic nanoplatform for precision‐imaging‐guided sensitized RT tumor still challenging. Herein, creation hypoxia‐targeted dendrimer‐entrapped gold nanoparticles complexed with gadolinium(III) (Gd‐Au DENPs‐Nit) dual‐mode CT/MR imaging and hypoxic tumors reported. In this work, generation 5 poly(amidoamine) dendrimers are partially conjugated Gd(III)...
Excess iron has been reported to lead osteoblastic cell damage, which is a crucial pathogenesis of overload-related osteoporosis. However, the cytotoxic mechanisms have not fully documented. In present study, we focused on whether necroptosis contributes overload-induced death and related underlying mechanisms. Here, showed that cytotoxicity overload in cells was mainly due necrosis, as evidenced by Hoechst 33258/PI staining, Annexin-V/PI transmission electronic microscopy. Furthermore,...
Abstract Background Although it has been suggested that loneliness is a risk factor for adverse health outcomes, living arrangement may confound the association. This study aimed to investigate whether associations of with outcomes differ in community-dwelling older adults according different arrangements. Methods In 2008/2009 wave Chinese Longitudinal Healthy Longevity Survey, 13,738 (≥65 years) were included analyses. Living arrangements and assessed. Health including cognitive physical...
As a fundamental problem in social influence propagation analysis, learning parameters has been extensively investigated. Most of the existing methods are proposed to estimate probability for each edge networks. However, they cannot effectively learn all edges due data sparsity, especially without sufficient observed propagation. Different from conventional methods, we introduce novel embedding problem, which is nodes rather than edges. Nodes represented as vectors low-dimensional space, and...
Background Iron overload is recognized as a new pathogenfor osteoporosis. Various studies demonstrated that iron could induce apoptosis in osteoblasts and osteoporosis vivo. However, the exact molecular mechanisms involved overload-mediated induction of has not been explored. Purpose In this study, we attempted to determine whether mitochondrial apoptotic pathway iron-induced osteoblastic cell death investigate beneficial effect N-acetyl-cysteine (NAC) cytotoxicity. Methods The MC3T3-E1 line...
Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells been considered promising tool reconstruction. The objective of this study was to investigate the proliferation osteogenic differentiation injectable chitosan/β-glycerophosphate/hydroxyapatite hydrogel vitro. chitosan /β-glycerophosphate were prepared using sol-gel method. injectability measured commercial...
The recent discovery of a large number histone methyltransferases reveals important roles these enzymes in regulating tumor development and progression. SMYD3, methyltransferase, is associated with poor prognosis patients prostate gastric cancer. In the study, we attempted to investigate its putative oncogenic role on bladder Here, report that SMYD3 frequently amplified cancer correlated progression prognosis. Overexpression promotes cell proliferation invasion, whereas knockdown inhibits...
STAT3, a member of the signal transducer and activator transcription (STAT) family, is strongly associated with liver injury, inflammation, regeneration, hepatocellular carcinoma development. However, signals that regulate STAT3 activity are not completely understood.Here we characterize CREB/ATF bZIP factor CREBZF as critical regulator in hepatocyte to repress regeneration. We show deficiency stimulates expression cyclin gene family enhances regeneration after partial hepatectomy. Flow...
Rationale: Development of intelligent radiosensitization nanoplatforms for imaging-guided tumor radiotherapy (RT) remains challenging.We report here the construction an nanoplatform based on poly(N-vinylcaprolactam) (PVCL) nanogels (NGs) co-loaded with gold (Au) and manganese dioxide (MnO2) nanoparticles (NPs) dual-mode computed tomography (CT)/magnetic resonance (MR) "full-process" sensitized RT tumors.Methods: PVCL NGs were synthesized via precipitation polymerization in situ loaded Au...
Objective: To study the efficacy of grip strength (GS) as a predictor cognitive function in large, nationwide sample Chinese participants aged 45 years and above. Methods: We used data from three waves (W1, W2, W3) fielded by China Health Retirement Longitudinal Study (CHARLS). Cognitive was tested biennially calculated using two categories: episodic memory mental intactness. Demographics, health behaviors, medical conditions were considered potential confounders. Using multivariate linear...
Development of a powerful sensitization system to alleviate radioresistance for enhanced tumor radiotherapy (RT) remains be explored. Herein, we present unique dual-mode endogenous and exogenous nanosensitizer based on dendrimer-entrapped gold nanoparticles (Au DENPs) realize RT. Methods: Generation 5 poly(amidoamine) dendrimers partially modified with 1,3-propanesultone were used templated synthesis Au NPs, the created zwitterionic DENPs adopted serum-enhanced delivery siRNA lead knockdown...