A5101481688- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- RNA modifications and cancer
- Cyclopropane Reaction Mechanisms
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Adenosine and Purinergic Signaling
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Diet, Metabolism, and Disease
- Insect Resistance and Genetics
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
- Entomopathogenic Microorganisms in Pest Control
- Plant biochemistry and biosynthesis
- Catalytic C–H Functionalization Methods
- Gut microbiota and health
- Plant Molecular Biology Research
- Autophagy in Disease and Therapy
- Solid State Laser Technologies
- Plant Virus Research Studies
- Photosynthetic Processes and Mechanisms
- Click Chemistry and Applications
Tianjin Medical University Cancer Institute and Hospital
2023-2025
Sichuan Agricultural University
2024-2025
Inner Mongolia Agricultural University
2025
University of California, San Diego
2025
Beijing Institute of Technology
2024
Zhejiang University
2022-2024
State Key Laboratory of Rice Biology
2022-2024
Nantong University
2023-2024
Chinese PLA General Hospital
2019-2024
Chengdu University of Traditional Chinese Medicine
2024
Abstract Microbial metabolites have emerged as critical components that mediate the metabolic effects of gut microbiota. Here, we show indole-3-propionic acid (IPA), a tryptophan metabolite produced by bacteria, is potent anti-non-alcoholic steatohepatitis (NASH) microbial metabolite. demonstrate administration IPA modulates microbiota composition in and inhibits dysbiosis rats fed high-fat diet. induces expression tight junction proteins, such ZO-1 Occludin, maintains intestinal epithelium...
Background ands Aims NAFLD is associated with elevation of many cytokines, particularly IL‐6; however, the role IL‐6 in remains obscure. The aim this study was to examine how myeloid‐specific signaling affects by regulation antifibrotic microRNA‐223 (miR‐223) myeloid cells. Approach and Results Patients or NASH healthy controls were recruited, serum soluble receptor α (sIL‐6Rα) measured. Compared controls, sIL‐6Rα levels elevated NAFLD/NASH patients. correlated positively number circulating...
Vascular smooth muscle cells (VSMCs) are an important source of foam in atherosclerosis. The mechanism for VSMC-derived cell formation is, however, poorly understood. Here, we demonstrate that the P2RY12/P2Y12 receptor is regulating macroautophagy/autophagy and advanced Inhibition P2RY12 ameliorated lipid accumulation high-fat diet-fed apoe-/- mice (atherosclerosis model) independent LDL-c levels. Activation blocked cholesterol efflux via PI3K-AKT, while genetic knockdown or pharmacological...
Abstract Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation Insig. Thr222 following activation required for protein stabilization Insig-1, inhibition cleavage processing SREBP-1, lipogenic expression response to metformin or A769662. AMPK-dependent ablates Insig’s interaction E3 ubiquitin ligase gp78...
Butyric acid is an intestinal microbiota-produced short-chain fatty acid, which exerts salutary effects on alleviating nonalcoholic liver disease (NAFLD). However, the underlying mechanism of butyrate regulating hepatic lipid metabolism largely unexplored.A mouse model NAFLD was induced with high-fat diet feeding, and sodium (NaB) intervention initiated at eighth week lasted for 8 weeks. Hepatic steatosis evaluated metabolic pathways concerning homeostasis were analyzed.Here, we report that...
INDUCER OF CBF EXPRESSION 1 (ICE1) encodes a MYC-like basic helix-loop-helix (bHLH) transcription factor playing critical role in plant responses to chilling and freezing stresses leaf stomata development. However, no information connecting ICE1 reproductive development has been reported. In this study, we show that controls male fertility via impacting anther dehydration. The loss-of-function mutation gene Arabidopsis caused indehiscence decreased pollen viability as well germination rate....
BackgroundNonalcoholic fatty liver disease (NAFLD) is associated with altered production of secreted proteins. Increased understanding proteins could lead to improved prediction and treatment NAFLD. Here, we aimed discover novel in humans that are hepatic fat content using unbiased proteomic profiling strategy, how the identified Thbs1 modulates lipid metabolism steatosis.MethodNAFLD patients were enrolled treated lifestyle intervention. Patients who underwent biopsy for analyzing...
STAT3, a member of the signal transducer and activator transcription (STAT) family, is strongly associated with liver injury, inflammation, regeneration, hepatocellular carcinoma development. However, signals that regulate STAT3 activity are not completely understood.Here we characterize CREB/ATF bZIP factor CREBZF as critical regulator in hepatocyte to repress regeneration. We show deficiency stimulates expression cyclin gene family enhances regeneration after partial hepatectomy. Flow...
Cry1Ac toxin-binding proteins from Helicoverpa armigera brush border membrane vesicles were identified by an improved pull-down method that involves coupling to CNBr agarose combined with liquid chromatography–tandem mass spectrometry (LC-MS/MS). According the LC-MS/MS results, toxin could bind six classes of aminopeptidase-N, alkaline phosphatase, cadherin-like protein, ATP-binding cassette transporter subfamily C protein (ABCC2), actin, ATPase, polycalin, and some other not previously...
In 2020 and 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, caused global pandemic. Vaccines are expected to reduce the pressure of prevention control, have become most effective strategy solve pandemic crisis. SARS-CoV-2 infects host by binding cellular receptor angiotensin converting enzyme (ACE2) via receptor-binding domain (RBD) surface spike (S) glycoprotein. this study, candidate vaccine based on RBD recombinant subunit was prepared means...
Objective: The role of intraoperative radiation therapy (IORT) in the management resectable pancreatic cancer (RPC) remains unclear. To date, application IORT using a low-energy X-ray source has not been extensively investigated. Therefore, this study was conducted to evaluate safety and efficacy 50 kV treating RPC. Methods: Patients with RPC who underwent radical pancreatectomy were enrolled. primary endpoint time treatment failure (TTF) survival, whereas secondary endpoints overall...
The harvesting age is a critical factor influencing the quality of medicinal crops, as it significantly affects content active compounds and clinical efficacy, which vary across different cultivation years. This study aims to clarify growth development patterns wild-simulated cultivated Astragalus mongholicus at ages provide theoretical practical guidance for determining its optimal age. morphological indicators, photosynthetic performance, stress resistance enzyme activities, compounds,...
Astragalus mongholicus, an important medicinal plant species, exhibits low tolerance to high-salt environments, which restricts its growth in saline–alkaline areas. Understanding salt-tolerance mechanisms is crucial for overcoming the technical challenges of industrialized cultivation these regions. However, studies on mongholicus are limited. This study examines two germplasms with distinct differences salt (LQ: salt-tolerant, DT: salt-sensitive), and investigates their physiological...
This research endeavored to explore the impact of Cr-Pic on abdominal fat deposition and lipid metabolism ducks, as well uncover mechanisms at play identify optimal dietary supplementation level Cr-Pic. The results showed that adding 0.6 mg/kg observably increased body weight serum levels adiponectin leptin, decreased total cholesterol, triglyceride, low-density lipoprotein cholesterol in ducks 14 days (P < 0.05). addition % was discovered regulate meat quality through its effects reducing...
Abstract Background: Pancreatic cancer, an immunologically "cold" tumor, poorly responds to immunotherapy. TAMs, key immune cells in its microenvironment, drive tumor progression. Despite recent progress macrophage-targeted therapies like CSF1R inhibitors, clinical results pancreatic cancer are disappointing, with unclear mechanisms. Surufatinib, a inhibitor, hinders macrophage differentiation into immunosuppressive state. Surufatinib alters pathways, but resistance is mediated by the...
A highly stereoselective desymmetrization reaction of δ,δ-diaryl-α-diazo-β-ketoesters catalyzed by chiral dirhodium carboxylates forms aromatic cycloaddition products in up to 97% ee.
Background: Our previous study suggested that the methylation of vitamin D receptor (VDR) gene affected its expression and defense against tuberculosis (TB) infection in vitro. In this study, we further investigated level VDR pulmonary TB patients. Methods: The consecutive patients who were admitted into our department from January 2013 to 2015 recruited. potential sites analyzed included 16 CpG sites. amplification bisulfite modified genomic DNA was ligated pUC18-T vector positive clone...
An enantioselective carbonyl–ene reaction of glyoxylate esters with 1,1-disubstituted alkenes catalyzed by chiral cationic dirhodium(II,III) carboxamidates is described. The paddlewheel having one open coordination site at each rhodium smoothly catalyze the to afford homoallylic alcohol products in good isolated yields high enantioselectivities.