A5101763085- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Meat and Animal Product Quality
- Endoplasmic Reticulum Stress and Disease
- Ginseng Biological Effects and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Liver physiology and pathology
- Virus-based gene therapy research
- Spectroscopy and Chemometric Analyses
- interferon and immune responses
- Cultural Heritage Materials Analysis
- Drug-Induced Hepatotoxicity and Protection
- Advanced Research in Science and Engineering
- Food Quality and Safety Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Polymer Surface Interaction Studies
- Microbial Metabolism and Applications
- Analytical Chemistry and Chromatography
- Viral Infectious Diseases and Gene Expression in Insects
- Soil Carbon and Nitrogen Dynamics
- Respiratory viral infections research
Shanxi University
2025
Mayo Clinic in Florida
2025
Shanxi University of Traditional Chinese Medicine
2025
Sichuan Tourism University
2022-2025
Sichuan Agricultural University
2025
Beijing Red Cross Blood Center
2025
New Zealand Leather & Shoe Research Association Inc.
2020-2024
Air Force Institute of Aviation Medicine Affiliated Hospital
2014-2024
Guangxi Academy of Agricultural Science
2024
Ministry of Agriculture and Rural Affairs
2024
Neomorphic IDH1 mutations disrupt the redox balance by promoting reactive oxygen species (ROS) production. However, mechanism which IDH1-mutant cells maintain ROS homeostasis remains elusive. It is also not known whether reprogrammed establishes targetable vulnerability in IDH1-mutated cancers.We investigated wild-type (GSC827, GSC923, GSC627, and GSC711) (IDH1R132C- IDH1R132H-transduced U87, U251; MGG152, TS603 cells). We analyzed stability transcriptional activity of NRF2 cells. The...
Endothelial oxidative injury is a key event in the pathogenesis of atherosclerosis (AS). Resveratrol (RSV) attenuates human umbilical vein endothelial cells (HUVECs). Autophagy critical for RSV-induced protective effects. However, exact underlying mechanisms haven't been completely elucidated. Thus, we aimed to explore role autophagy anti-oxidation RSV and mechanism palmitic acid (PA)-stimulated HUVECs.HUVECs were pretreated with 10 μM 2 h treated 200 PA an additional 24 h. Cell viability,...
Infection by chronic hepatitis B virus (HBV) is one of the major causes liver cirrhosis and primary hepatocellular carcinoma (HCC). Viral DNA integration into host cell genome a key mechanism hepatocarcinogenesis. However, molecular characterization potential clinical implications HBV patients suffering from different HCC remain unclear. In this study, we analyzed integrations in with using probe-based capturing next-generation sequencing. The results revealed that sizes ranged 28 bp to 3215...
Non-alcoholic fatty liver disease (NAFLD) has become one of the main chronic diseases worldwide. Protopanaxadiol (PPD), an active compound derived from Gynostemma pentaphyllum, been found able to improve free acid-induced lipid accumulation in hepatocytes. However, efficacy PPD on NAFLD and underlying mechanism remains unknown. In this study, mice were fed with a high-fat diet for 22 weeks induce model, then treated by gavage 8 weeks. Moreover, AML12 HepG2 cells induced acids 24 h, different...
Abstract Chronic hepatitis B virus (HBV) infection is partly responsible for hepatitis, fatty liver disease and hepatocellular carcinoma (HCC). HBV core protein (HBc), encoded by the genome, may play a significant role in life cycle. However, function of HBc occurrence development still unclear. To investigate underlying mechanisms, HBc-transfected HCC cells were characterized multi-omics analyses. Combining proteomics metabolomics analyses, our results showed that promoted expression...
Hepatitis B surface antigen (HBsAg) clearance is considered as functional cure in patients with chronic hepatitis (CHB). This study aimed to assess the durability of HBsAg achieved by interferon-based therapies CHB who were originally positive for envelope (HBeAg). In this prospective study, HBeAg-positive confirmed loss under enrolled within 12 weeks from end treatment and followed up 48 weeks. Virological markers, biochemical indicators, liver imaging examinations observed every 3-6...
Pre-vascularization of scaffolds using endothelial cells (ECs) and preservation hemocompatibility are effective strategies to improve the long-term viability tissue engineered constructs. The current work reports a multifunctional titanium (Ti) surface for simultaneous enhancement EC selectivity while preserving hemocompatibility. This is achieved by REDV conjugation on surface-grafted PEGMA polymer brushes via surface-initiated atom transfer radical polymerization (ATRP) dopamine...
Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle pose extremely high costs to the healthcare system. In this study, we aim explore whether individualized aerobic exercise (AEx) low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition other post-interventional effects. A 6-month randomized follow-up is conducted from January 2013 December 2015. The target sample...
Abstract Ginseng occupies a prominent position in the list of best-selling natural products worldwide. Asian ginseng ( Panax ) and American quinquefolius show different properties medicinal applications pharmacology, even though main active constituents them are both thought to be ginsenosides. Metabolomics is promising method profile entire endogenous metabolites monitor their fluctuations related exogenous stimulus. Herein, an untargeted metabolomics approach was applied study overall...
The activated c-Jun N-terminal kinase (JNK) specifically combined with SH3 domain-binding protein 5 (Sab) may mediate damage to the mitochondrial respiratory chain. Whether dysfunction induced by JNK/Sab signaling pathway plays a pivotal role in lipotoxic injury of nonalcoholic steatohepatitis (NASH) remains lack evidence. Scoparone, natural compound from Traditional Chinese Medicine herbs, has potential for liver protection and lipid metabolism regulation. However, effect scoparone on NASH...
Ethnopharmacological relevanceAs a classic formula, Ermiao San (EMS) characterized by its less medicinal flavor and strong potency had been proven to be effective safe in the treatment of rheumatoid arthritis (RA) during clinical experience our previous research.Aim studyThe therapeutic characteristics multi-component multi-target traditional Chinese medicine prompted us further investigated compounds EMS, evaluated potential mechanisms treating RA.Materials methodsFirstly,...
This research endeavored to explore the impact of Cr-Pic on abdominal fat deposition and lipid metabolism ducks, as well uncover mechanisms at play identify optimal dietary supplementation level Cr-Pic. The results showed that adding 0.6 mg/kg observably increased body weight serum levels adiponectin leptin, decreased total cholesterol, triglyceride, low-density lipoprotein cholesterol in ducks 14 days (P < 0.05). addition % was discovered regulate meat quality through its effects reducing...
Many scholars have studied Tricholoma matsutake soup, but there are relatively few studies exploring the aroma changes during its cooking process using different detection methods. The of T. soup was analyzed and compared electronic nose (E-nose) analysis, headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS), headspace-solid-phase microextraction-gas chromatography-mass (HS-SPME-GC-MS). A significant effect time on overall profile identified through E-nose analysis. By...
Liver transplantation is the key treatment for liver failure, yet organ scarcity, exacerbated by high discard rates of steatotic livers, leads to waitlist mortality. Preclinical models steatosis are necessary understand pathophysiology disease and develop pharmacological interventions decrease burden rate. In this paper, we an expedited 3D organoid model containing primary human hepatocytes non-parenchymal cells. We present our iterative approach as transition from 2D immortalized cells...
Assessing immune responses across diverse populations is essential for refining public health strategies. Blood donors offer valuable insights into community-level immunity. This study aims to investigate associated with inactivated COVID-19 booster immunization and breakthrough infections in blood donors. was conducted a cohort of from six centers five China's seven major geographical regions, spanning December 2021 February 2023. samples were collected before vaccination, at 1, 3, 6 months...
Reducing the thrombogenicity of a tissue-engineered vascular graft prior to implantation is important for improving patency. As functionalization synthetic materials with cell-adhesive proteins routinely utilized as means promote endothelial cell (EC) growth, we conducted detailed investigation on proliferation and ECs such functionalized surfaces. We observed that polycaprolactone (PCL) surfaces poly(glycidyl methacrylate) [(P(GMA)] brushes via atom transfer radical polymerization (ATRP)...
Objective To explore dynamic changes of cytokines and virological markers associated with hepatitis B surface antigen (HBsAg) loss during peginterferon alpha-2a (PEG-IFN α-2a) treatment in e (HBeAg) positive chronic (CHB) patients. Methods It was a single-center prospective cohort study. HBeAg-positive CHB patients were prospectively consecutively enrolled. Cytokines detected at baseline, week 12 24 PEG-IFN treatment. HBsAg disappearance rate the primary evaluation index 48 weeks Results...