A5018902489- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Liver Diseases and Immunity
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Blood groups and transfusion
- Folate and B Vitamins Research
- Inflammasome and immune disorders
- Respiratory viral infections research
- Heterotopic Ossification and Related Conditions
- Pharmacological Effects of Natural Compounds
- Autoimmune and Inflammatory Disorders Research
- Diabetes and associated disorders
- interferon and immune responses
Capital University
2020-2025
Beijing Ditan Hospital
2016-2025
Capital Medical University
2016-2025
Peking University
2011-2025
University of South China
2025
Huazhong University of Science and Technology
2004-2024
University of Electronic Science and Technology of China
2023-2024
Ministry of Ecology and Environment
2024
Donghua University
2024
First Hospital of Jilin University
2024
Background and Aims: Hepatitis B surface antigen (HBsAg) loss is seldom achieved with nucleos(t)ide analog (NA) therapy in chronic hepatitis patients but may be enhanced by switching to finite pegylated-interferon (Peg-IFN) alfa-2a. We assessed HBsAg 48- 96-week Peg-IFN alfa-2a partial response a previous NA. Methods: e (HBeAg)-positive who HBeAg virus DNA <200 IU/mL adefovir, lamivudine or entecavir treatment were randomized 1:1 receive for 48 (n = 153) 96 weeks 150). The primary endpoint...
Nucleotides with add-on interferon treatment (NUC-IFN) provide significantly higher rates of hepatitis B surface antigen (HBsAg) loss in patients chronic (CHB). This study aimed to investigate the sustainability HBsAg and prevention clinical relapse.Patients CHB who achieved HBV DNA levels <20 IU/ml after IFN or NUC-IFN therapy were enrolled followed up for 96 weeks. The primary outcome was negativity without viremia at week 96. Secondary outcomes included virological relapse predictors...
Background Observational studies have demonstrated an association between white blood cells (WBC) subtypes and type 2 diabetes (T2D) risk. However, it is unknown whether this relationship causal. We used Mendelian randomization (MR) to investigate the causal effect of WBC on T2D glycemic traits. Methods The summary data for neutrophil, lymphocyte, monocyte, eosinophil, basophil counts were extracted from a recent genome-wide study (n = 173,480). DIAGRAM MAGIC consortia offered pertaining...
Introduction: We aimed to characterize postpartum disease flares among treatment-naive mothers with chronic hepatitis B (CHB). CHB were enrolled and compared non-infected in terms of alanine aminotransferase (ALT) abnormalities. Methods: Demographic, virological, biochemical parameters collected up week 16, exacerbations defined as ALT levels 5–10 >10 times the upper limit normal, respectively. Outcome assessments included or exacerbation their predictive parameters. Results: Among 4236...
To compare the long-term efficacy and safety of glycyrrhizic acid preparation hormone treatment in patients with autoimmune hepatitis, we enrolled 377 a study that lasted from January 2009 to 2020. After performing propensity score matching, included 58 group statistical analysis. We then compared ratio sustained biochemical responses at 48 weeks after treatment. Adverse events, including some incidence decompensated liver cirrhosis cancer, were evaluated. The results showed total 61.8%...
Birth weight is a good predictor of fetal intrauterine growth and long-term health, several studies have evaluated the relationship between metabolites birth weight. The aim this study was to investigate association cord blood metabolomics lipidomics with weight, using two-stage discovery validation approach.
Background and Aims: Studies have shown that blocking the programmed cell death-1/programmed death ligand 1 pathway may lead to a potential cure for HBV infections. ASC22 (envafolimab) is humanized, single-domain antibody administered subcutaneously. This study aimed evaluate efficacy safety of in virally suppressed patients with chronic hepatitis B on nucleos(t)ide analogs. Approach Results: randomized, single-blind, phase IIb trial enrolled 2 cohorts 24-week treatment or placebo (PBO) once...
Abstract Background Gasdermin E (GSDME) is a newly identified pyroptosis executioner and upregulated in the intestinal epithelial cell (IEC) of ulcerative colitis (UC) patients. However, effects GSDME on UC remain unknown. Methods Bone marrow chimera experiments were performed to investigate role nonhematopoietic cells, mainly including IECs. An FITC-dextran assay was used assess integrity barrier. Results Gsdme–/– chimeras that reconstituted with wild-type bone cells exhibited lower weight...
To describe 32 cases of acute fatty liver pregnancy (AFLP) and identify the potential clinical predictors maternal fetal outcomes in South China.Thirty-two AFLP previously treated First Affiliated Hospital Nanchang University past 10 years were enrolled current study.Sex fetus delivery method was predictor outcome. The main manifestations jaundice (n = 32), nausea vomiting 28), malaise 25), ascites its complications included renal failure 26), hepatic encephalopathy 17), infection 10),...
Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: designed multicenter 1:1 matched case-control study of 307 pairs gastric cancers controls between October 2010 August 2011. were sequenced, demographic data as well lifestyle factors collected using self-designed questionnaire. Results: Individuals carrying Trp/Trp or Arg/Trp variant genotype had significantly increased risk (OR,...
To investigate the safety of inactivated COVID-19 vaccine in Chinese pregnant women and their fetuses when inoculated during peri-pregnancy period.Eligible were prospectively collected divided into a group (n = 93) control 160) according to whether they had been vaccinated against within 3 months before last menstruation period (LMP) after pregnancy. Demographic data couples, complications pregnancy delivery women, newborns at birth collected.Sixty-six with median time 35.5 (range 0-91) days...
Objective To explore dynamic changes of cytokines and virological markers associated with hepatitis B surface antigen (HBsAg) loss during peginterferon alpha-2a (PEG-IFN α-2a) treatment in e (HBeAg) positive chronic (CHB) patients. Methods It was a single-center prospective cohort study. HBeAg-positive CHB patients were prospectively consecutively enrolled. Cytokines detected at baseline, week 12 24 PEG-IFN treatment. HBsAg disappearance rate the primary evaluation index 48 weeks Results...
patients had a decrease in HBV DNA > 2 log10 IU/mL the vaccine group at week 12 after EOT compared with control group.A trend toward difference number of undetectable 28 was obtained.Adverse events were similar.In dynamic per-protocol set, which excluded adefovir (ADV) add-on cases each time point instantly ADV administration due to LAM antiviral failure, more and group.More also observed.Among viral load < 1000 copies/mL 12, achieved HBeAg seroconversion than among controls 36 EOT, as well...
Abstract Liver necroinflammation is the indicator for treating patients with chronic hepatitis B (CHB) infection. However, there no suitable non‐invasive index diagnosing liver necroinflammation. This study aimed to create a predict in who lack clear‐cut clinical inflammation parameters. Patients were e antigen (HBeAg)‐negative and underwent histological diagnosis, had normal or minimally increased alanine aminotransferase (ALT) level enrolled. was defined as active ≥4. A logistic regression...
Gastric cancer (GC) is one of the most common malignancies and its mortality ranks third among all cancers in China. We previously noted that XRCC1 Arg194Trp was associated with GC risk Western China a study on ADPRT Val762Ala. aimed to further explore association these polymorphisms noncardia subtype.We enrolled 176 patients 308 controls from four hospitals community between October 2010 August 2011. Genotyping performed 384-well plate format Sequenom MassARRAY platform. A self-designed...
Summary Women with chronic hepatitis B should maintain nucleotide analogue treatment to prevent disease progression during pregnancy. The aim of this study was prospectively evaluate the efficacy and safety telbivudine used throughout pregnancy for preventing virus ( HBV ) mother‐to‐child transmission MTCT ). From January 2012 June 2014, women who were receiving therapy became pregnant enrolled in group A at 28 weeks gestation. Pregnant an DNA level >10 6 IU/mL either (telbivudine started...