A5100339161- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Hepatitis B Virus Studies
- Esophageal Cancer Research and Treatment
- Acupuncture Treatment Research Studies
- Virus-based gene therapy research
- Thyroid Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
Sichuan University
2016-2025
West China Hospital of Sichuan University
2005-2025
AstraZeneca (United Kingdom)
2023-2025
Guang’anmen Hospital
2020-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Sun Yat-sen University
2006-2025
China Academy of Chinese Medical Sciences
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Changzhou No.2 People's Hospital
2025
Nanjing Traditional Chinese Medicine Hospital
2025
This study was performed to prospectively develop and validate a radiomics nomogram for predicting postoperative early recurrence (≤1 year) of hepatocellular carcinoma (HCC) using whole-lesion features on preoperative gadoxetic acid-enhanced magnetic resonance (MR) images.In total, 155 patients (training cohort: n = 108; validation 47) with surgically confirmed HCC were enrolled in this IRB-approved prospective study. Three-dimensional regions interest manually delineated along the tumour...
Rationale: Many viral infections are known to activate the p38 mitogen-activated protein kinase (MAPK) signaling pathway. However, role of activation in infection and underlying mechanism remain unclear. The virus-hijacked MAPK was investigated this study. Methods: correlation hepatitis C virus (HCV) studied patient tissues primary human hepatocytes (PHHs) by immunohistochemistry western blotting. Coimmunoprecipitation, GST pulldown confocal microscopy were used investigate interaction p38α...
Autophagy reduces tumor cell sensitivity to T killing; thus, inhibiting autophagy may improve cell–engaging therapies.
Introduction Intervertebral disc degeneration (IVDD) is an important contributor of low back pain, which represents one the most disabling symptoms within adult population. Recently, increasing evidence suggests potential association between Type 2 diabetes mellitus (T2DM) and IVDD. However, causal relationship these two common diseases remains unclear. Methods We conducted a two-sample Mendelian randomization (MR) analysis to assess T2DM Sensitivity was performed test for heterogeneity...
The aim of this study was to prospectively evaluate the diagnostic efficacy diffusion kurtosis imaging (DKI) in predicting microvascular invasion (MVI) and histologic grade hepatocellular carcinoma (HCC) with comparison conventional diffusion-weighted (DWI).This prospective approved by Institutional Review Board, written informed consent obtained from all patients. From September 2015 January 2017, 74 consecutive HCC patients were enrolled study. Preoperative magnetic resonance including DKI...
This retrospective study aimed to develop and validate deep-learning-based models for grading clear cell renal carcinoma (ccRCC) patients. A cohort enrolling 706 patients (n = 706) with pathologically verified ccRCC was used in this study. temporal split applied verify our models: the first 83.9% of cases (years 2010-2017) development last 16.1% (year 2018-2019) validation (development cohort: n 592; 114). Here, we demonstrated a deep learning(DL) framework initialized by self-supervised...
Poor adherence leads to a high rate of exacerbation and poor health-related quality life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). However, few strategies are acceptable effective improving medication adherence. We investigated whether pharmaceutical care by clinical pharmacists could reinforce reduce improve HRQoL.A randomized controlled study was carried out at The First Affiliated Hospital Guangzhou Medical University from February 2012 January 2014....
The Liver Imaging Reporting and Data System (LI-RADS) European Association for the Study of (EASL) criteria are widely used diagnosing hepatocellular carcinoma (HCC). Radiomics allows further quantitative tumor heterogeneity profiling. This study aimed to compare diagnostic accuracies version 2018 (v2018) EASL, LI-RADS radiomics models HCC in high-risk patients. Ethical approval by institutional review board informed consent were obtained this study. From July 2015 September 2018,...
Combined hepatocellular and cholangiocarcinoma (CHC) intrahepatic (ICC) are hard to identify in clinical practice preoperatively. This study looked develop confirm a radiomics-based model for preoperative differentiation CHC from ICC.
An accurate preoperative assessment of cervical lymph node metastasis (LNM) is important for choosing an optimal therapeutic strategy papillary thyroid carcinoma (PTC) patients. This study aimed to develop and validate two ultrasound (US) nomograms the individual prediction central lateral compartment LNM in patients with PTC.A total 720 PTC from 3 institutions were enrolled this study. They categorized into a primary cohort, internal validation, external validation cohorts. Radiomics...
Cervical cancer is a potentially preventable disease; however, it the third most commonly diagnosed and fourth leading cause of deaths in women worldwide. thought to develop through multistep process involving virus, tumor suppressor genes, proto‑oncogenes immunological factors. It known that human papillomavirus (HPV) infection necessary but insufficient malignancy. At present, etiology cervical carcinoma remains poorly understood. In this study, we found expression FOS‑like antigen‑1...
To investigate the value of whole-lesion texture analysis on preoperative gadoxetic acid enhanced magnetic resonance imaging (MRI) for predicting tumor Ki-67 status after curative resection in patients with hepatocellular carcinoma (HCC).This study consisted 89 consecutive surgically confirmed HCC. Texture features were extracted from multiparametric MRI based regions interest. The was immunohistochemical determined and classified into low (labeling index ≤15%) high >15%) groups. Least...
Neoalbaconol, derived from Albatrellus confluens , shows anti‐cancer activities in the previously study, but its role angiogenesis is unknown. Here, we determined whether neoalbaconol could attenuate and how does it occur. Data demonstrated that inhibit proliferation of breast cancer cells induce apoptosis. Also, suppressed vascular endothelial growth factor (VEGF)‐induced human umbilical (HUVECs) proliferation, migration, invasion, capillary‐like tube formation vitro reduced tumor vivo ....
Programmed cell death protein-1 (PD-1) and programmed death-ligand-1 (PD-L1) expression status, determined by immunohistochemistry (IHC) of specimens, can discriminate patients with hepatocellular carcinoma (HCC) who derive the most benefits from immune checkpoint inhibitor (ICI) therapy. A non-invasive method measuring PD-1/PD-L1 is urgently needed for clinical decision support.We included a cohort 87 HCC West China Hospital analyzed 3094 CT images to develop validate our prediction model....
To determine the current age at orchidopexy in China and whether changing targets have altered practice, as research suggesting progressive deterioration an undescended testis (UDT) has led to reduction target for 6-12 months but it is still unknown practice.The demographics of orchidopexies performed Children's Hospital Chongqing Medical University between 1993 2014 were reviewed. A survey general publics' awareness UDT primary healthcare practitioners' opinion on referral patterns...
To compare intravoxel incoherent motion (IVIM)-derived parameters with conventional diffusion-weighted imaging (DWI) in predicting the histological grade of hepatocellular carcinoma (HCC) and to evaluate correlation between grades.A retrospective study was performed. Sixty-two patients surgically confirmed HCCs underwent magnetic resonance twelve b values (10-1200 s/mm2). The apparent diffusion coefficient (ADC), pure (D), pseudo-diffusion (D*), perfusion fraction (f) were calculated by two...