A5088617130- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Gestational Trophoblastic Disease Studies
- Teratomas and Epidermoid Cysts
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Ferroptosis and cancer prognosis
- Intestinal and Peritoneal Adhesions
- Maternal and Perinatal Health Interventions
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer therapeutics and mechanisms
- Melanoma and MAPK Pathways
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Calcium signaling and nucleotide metabolism
- Ovarian cancer diagnosis and treatment
- Toxin Mechanisms and Immunotoxins
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
Central South University
2016-2025
Third Xiangya Hospital
2016-2025
Peking University First Hospital
2021
Peking University
2021
University of Birmingham
2021
Guangdong Medical College
2019
Guangdong Pharmaceutical University
2019
Xiangya Hospital Central South University
2014-2019
Chongqing Medical University
2015
Second Affiliated Hospital of Xi'an Jiaotong University
2002
The aim of this study was to retrospectively evaluate the safety and feasibility high-intensity focused ultrasound (HIFU) treatment combined with suction curettage under hysteroscopic guidance for cesarean scar pregnancy (CSP). Fifty-three patients definite CSP were treated HIFU followed by guidance. All received 1 session ablation conscious sedation. Suction performed at an average 2.9 (range: 1–5) days after ablation. Blood flow tissue before HIFU, intraoperative blood loss in hysteroscopy...
The aim of this study was to compare the therapeutic outcomes high-intensity focused ultrasound (HIFU) and surgical treatment for abdominal wall endometriosis.A retrospective study.Gynaecological department a teaching hospital in China.Patients with endometriosis.Among 51 patients, 23 patients were treated ultrasound-guided HIFU 28 surgery. Pain relief size change nodule after each management evaluated 1, 3, 6 12 months treatment, respectively. stay blood loss also compared.Difference...
As transcription and replication use DNA as substrate, conflicts between can occur, leading to genome instability with direct consequences for human health. To determine how the two processes are coordinated throughout S phase, we characterize both together at high resolution. We find that occurs during replication, start sites (TSSs) not fully replicated along surrounding regions remaining under-replicated until late in cell cycle. TSSs undergo completion of specifically when cells enter...
Cervical cancer is a potentially preventable disease; however, it the third most commonly diagnosed and fourth leading cause of deaths in women worldwide. thought to develop through multistep process involving virus, tumor suppressor genes, proto‑oncogenes immunological factors. It known that human papillomavirus (HPV) infection necessary but insufficient malignancy. At present, etiology cervical carcinoma remains poorly understood. In this study, we found expression FOS‑like antigen‑1...
Purpose: The aim of this study was to retrospectively analyse the clinical data 122 patients with caesarean scar pregnancy (CSP) treated in our hospital, compare outcomes between high-intensity focused ultrasound (HIFU) and uterine artery embolisation (UAE). Materials methods: Among patients, 76 were HIFU followed by suction curettage under hysteroscopic guidance, 46 UAE guidance. Pain score, intraoperative blood loss hysteroscopy time for vaginal bleeding, β-human chorionic gonadotropin...
Minichromosome maintenance 2 (MCM2) is a member of the minichromosomal family proteins that mainly regulates DNA replication and cell cycle involved in regulating cancer proliferation various cancers. Previous studies have reported MCM2 plays pivotal role development. However, few articles systematically pathogenic roles across Therefore, present pan-cancer study was conducted. Various computational tools were used to investigate expression level, genetic mutation rate, mechanism, immune...
Abstract Objective To investigate the clinical efficacy of hysteroscopic‐assisted laparoscopic incised‐suture versus folded‐suture methods at cesarean incision site for treatment previous scar defects (PCSD) and to evaluate pregnancy outcomes. Methods This was a retrospective analysis 95 patients with PCSD who underwent surgery between June 2021 September 2024 Third Xiangya Hospital Central South University. Results There were no significant differences in population characteristics such as...
Cervical cancer is one of the most common malignant tumors in women all over world. The exact mechanism occurrence and development cervical has not been fully elucidated. CD38 a type II transmembrane glycoprotein, which was found to mediate diverse activities, including signal transduction, cell adhesion, cyclic ADP-ribose synthesis. Here, we reported that promoted proliferation inhibited apoptosis cells by affecting mitochondria functions. We established stable lines with over-expressed....
The oncogenesis of cervical cancer is a multi-factor and multi-step process, major risk factors include oncogene activation with tumor suppressor gene inactivation, viral factors, immune factors. For example, the human papillomavirus (HPV) has been linked to occurrence cancer. At present, pathogenesis remains unclear. Fra-1 (Fos-related antigen 1, also known as FOSL1) member Fos family an important nuclear transcription factor that regulates normal cell growth, differentiation, apoptosis. In...
Abstract Objective To compare and analyze the clinical efficacy reproductive outcomes of hysteroscopic tissue removal system (MyoSure) electroresection in treatment benign intrauterine lesions women age. Methods This is a retrospective study patients with treated MyoSure or electroresection. The primary were operative time resection completeness, followed up compared. Secondary included perioperative adverse events postoperative adhesions seen during second‐look hysteroscopy. Data analysis...
Epithelial ovarian cancer (EOC) is the most malignant gynaecologic carcinoma and of a high incidence death due to detection at late stages when metastasis already occurs. However, mechanism underlying EOC remains unclear. Analysis open database experiments with immunochemistry showed that LRRC4 lowly expressed in high-grade serous (HGSC) cells during metastasis. The 3D cell culture system orthotopic xenograft model infected LRRC4-containing adeno-associated virus serotype 9 (AAV9) were used...
Background Ovarian cancer (OC) has the highest mortality rate among gynecologic malignancy. Hypoxia is a driver of malignant progression in OC, which results poor prognosis. We herein aimed to develop validated model that was based on hypoxia genes systematically evaluate its prognosis tumor immune microenvironment (TIM). Results identified 395 hypoxia-immune using weighted gene co-expression network analysis (WGCNA). then established nine hypoxia-related risk least absolute shrinkage and...