A5100678989- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Lipid metabolism and disorders
- Pancreatitis Pathology and Treatment
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Viral gastroenteritis research and epidemiology
- Folate and B Vitamins Research
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Healthcare and Venom Research
- Cardiovascular Disease and Adiposity
- Pharmacological Effects of Natural Compounds
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Traditional Chinese Medicine Studies
- Metal-Organic Frameworks: Synthesis and Applications
Fujian Academy of Agricultural Sciences
2025
Fruit Research Institute
2025
Wenzhou Medical University
2014-2024
First Affiliated Hospital of Wenzhou Medical University
2014-2024
Sichuan University
2024
Union Hospital
2024
Peking University
2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
Cambridge University Press
2013-2021
New York University Press
2013-2021
Coronavirus disease 2019 (COVID-19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVID-19 severity, it not whether nondiabetic patients with metabolic dysfunction are also more prone severe disease. The association of associated fatty liver (MAFLD) severity in was investigated here.The study cohort comprised 65 (i.e. cases) and without MAFLD controls). Each case randomly matched one control by sex (1:1) age (±5 years). between the presence (as exposure)...
The Corona Virus Disease 2019 (COVID-19) pandemic has attracted increasing worldwide attention. While metabolic-associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVID-19 severity not been characterized. We identified 55 MAFLD patients with COVID-19, who were 1:1 matched by age, sex and obesity status to non-aged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected without MAFLD. Our results demonstrate that in aged less than 60...
Chronic hepatitis B (CHB) and liver fibrosis are associated with a high risk of hepatocellular carcinoma (HCC) development. We assessed whether entecavir (ETV) plus Biejia-Ruangan compound (BRC), an anti-fibrotic traditional Chinese medicine, can further reduce the HCC in treatment-naïve patients CHB Ishak score ≥3 points derived from our parent double-blind randomized placebo-controlled trial.After 72-week comparison between ETV+BRC ETV+placebo treatment, participants were eligible to enter...
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphism is associated with NAFLD severity and the PNPLA3 gene expressed in kidneys, but whether also renal tubular injury (RTI) uncertain. We assessed effect of genotypes on biomarkers RTI glomerular function subjects who had either normal (nALT) or abnormal (abnALT) alanine aminotransaminase levels.Two hundred seventeen patients histologically proven which 75 persistently nALT (below upper limit for months) were...
The aim of this study was to examine the association between sex-specific serum uric acid (sUA) levels and NAFLD in a large population-based study. A total 60,455 subjects from 2 separate medical centers were included. Sex-specific sUA quartiles (Q1–Q4) defined: ≤330, 331–380, 381–435, ≥436 μmol/L for male; ≤230, 231–270, 271–310, ≥311 female. odds ratios (ORs), hazard (HRs), 95% confidence intervals (CIs) calculated across each quartile sUA, using Q1 as reference. After adjusting known...
Background and aim Imaging-confirmed non-alcoholic fatty liver disease (NAFLD) with normal alanine aminotransferase (nALT) levels is infrequently the subject for further evaluation. Early diagnosis of steatohepatitis (NASH) needed to prevent progression. Thus, we tested clinical utility serum Golgi protein 73 (GP73) developed a new non-invasive score diagnose NASH in patients biopsy-confirmed NAFLD persistent nALT levels. Methods Serum GP73 cytokeratin-18 M30 fragments (CK18-M30) were...
Long-term nucleos(t)ide analogue (NA) treatment can reverse liver fibrosis in chronic hepatitis B (CHB), but its effect on regression remains limited. Biejia-Ruangan (BR) has been approved China as an antifibrotic traditional Chinese medicine drug patients with diseases. A multicenter randomized controlled trial aims to evaluate the of BR CHB treated NAs.CHB histologically confirmed advanced or cirrhosis were randomly assigned receive entecavir (ETV) (0.5 mg per day) plus (2 g 3 times a...
Abstract Background The presence of significant liver fibrosis is a key determinant long‐term prognosis in non‐alcoholic fatty disease (NAFLD). We aimed to develop novel machine learning algorithm (MLA) predict severity NAFLD and compared it with the most widely used non‐invasive biomarkers. Methods cohort 553 adults biopsy‐proven NAFLD, who were randomly divided into training (n = 278) for development both logistic regression model (LRM) MLA, validation 275). Significant was defined as...
Background and Aim Circulating levels of interleukin (IL)-6, a well-known inflammatory cytokine, are often elevated in coronavirus disease-2019 (COVID-19). Elevated IL-6 also observed patients with metabolic dysfunction-associated fatty liver disease (MAFLD). Our study aimed to describe the association between circulating MAFLD at hospital admission risk severe COVID-19. Methods A total 167 laboratory-confirmed COVID-19 from three Chinese hospitals were enrolled. IL-2, IL-4, IL-6, IL-10,...
Introduction Enteric dysbacteriosis is strongly associated with nonalcoholic fatty liver disease (NAFLD). However, the underlying causal relationship remains unknown. Thus, present study aimed to investigate between gut microbiota and NAFLD using Mendelian randomization (MR) analyze target genes potentially regulated by specific microbiota. Methods Bidirectional two-sample MR analysis was performed inverse variance weighted (IVW) supplemented MR-Egger, median, simple mode, mode methods. Data...
Background and Aims: Studies have shown that blocking the programmed cell death-1/programmed death ligand 1 pathway may lead to a potential cure for HBV infections. ASC22 (envafolimab) is humanized, single-domain antibody administered subcutaneously. This study aimed evaluate efficacy safety of in virally suppressed patients with chronic hepatitis B on nucleos(t)ide analogs. Approach Results: randomized, single-blind, phase IIb trial enrolled 2 cohorts 24-week treatment or placebo (PBO) once...
A positive association between hypertension or high-normal blood pressure (BP) and risk of nonalcoholic fatty liver disease (NAFLD) is well-known; however, no data have been generated exploring the NAFLD within normal range BP. We aimed to assess systolic (SBP) NAFLD. total 27,769 subjects from 2 separate medical centers were included. Subjects divided into 4 groups (G1 G4) by SBP levels: G1: 90–99 mmHg, G2: 100–109 G3: 110–119 G4: 120–129 mmHg. The prevalence, hazard ratios (HRs) 95%...
Background Fibrosis is deemed to be a pivotal determinant of the long‐term prognosis in non‐alcoholic fatty liver disease (NAFLD). Objective We aimed develop novel nomogram‐based non‐invasive model accurately predict significant fibrosis patients with NAFLD. Methods designed prospective cohort study including 207 biopsy‐proven Detailed anthropometric and fibrosis‐related laboratory parameters were collected. A nomogram was established based on variables that independently associated...
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M (rs738409) genotype influences clinical/biochemical characteristics in patients with nonalcoholic fatty liver disease (NAFLD), but whether PNPLA3-I148M also the diagnostic performance of noninvasive tests for NAFLD is uncertain. Our aim was to investigate differences according genotype.Fifty-eight healthy controls and 349 biopsy-proven were included. Areas under receiver operating characteristic curve (AUROCs) calculated...
INTRODUCTION: Little reliable evidence has been reported regarding usefulness of liver stiffness measurement (LSM) for monitoring the hepatic fibrosis changes during treatment. We aimed to assess association between in LSM and histological outcomes patients with chronic hepatitis B. METHODS: In this prospective multicenter study, 727 treatment-naive receiving entecavir-based therapy, who underwent paired biopsies at treatment baseline week 72, were analyzed. Changes defined as ≥30% decrease,...