A5100628285- Liver Disease Diagnosis and Treatment
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Adipokines, Inflammation, and Metabolic Diseases
- Trauma Management and Diagnosis
- Immunotherapy and Immune Responses
- Retinal Diseases and Treatments
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Acute Myocardial Infarction Research
- Immune Cell Function and Interaction
- Sperm and Testicular Function
- Electrospun Nanofibers in Biomedical Applications
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Nerve injury and regeneration
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Maritime Navigation and Safety
- Traditional Chinese Medicine Analysis
Yunnan University
2013-2025
Hohai University
2024
Second People's Hospital of Yunnan Province
2011-2024
Sichuan Cancer Hospital
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2021-2023
Shanghai University of Traditional Chinese Medicine
2017-2023
Shanghai University of Medicine and Health Sciences
2023
Soochow University
2012-2022
The University of Texas Health Science Center at Houston
2014-2022
Zhengzhou University
2018-2021
Abstract Background Vascular endothelial growth factor (VEGF)-induced angiogenesis is a critical compensatory response to microvascular rarefaction in the diabetic retina that contributes proliferative retinopathy (PDR). In this study, we sought determine role of specific micro ribonucleic acids (RNAs) (miRs) associated with VEGF patients PDR pathology. Methods RNA sequencing was employed detect differentially circulating miR diabetes mellitus (DM), nonproliferative (NPDR) and PDR....
Diabetic retinopathy (DR) is a specific neurovascular complication of diabetes mellitus (DM). Clinically, family history widely recognized risk factor for DR, assisting diagnosis and strata. However, among great amount DR patients without hereditary like hypertension diabetes, direct simple factors to assist clinical decisions are still required. Herein, we intend investigate the associated these based on systemic inflammatory response indexes, neutrophil-to-lymphocyte ratio (NLR)...
The two major intracellular protein degradation systems, the ubiquitin-proteasome system (UPS) and autophagy, work collaboratively in many biological processes including development, apoptosis, aging, countering oxidative injuries. We report here that, human retinal pigment epithelial cells (RPE), ARPE-19 cells, proteasome inhibitors, clasto-lactacystinβ-lactone (LA) or epoxomicin (Epo), at non-lethal doses, increased levels of autophagy-specific genes Atg5 Atg7 enhanced conversion...
Graphene oxide (GO) modified with hyaluronic acid (HA) and Arg-gly-asp peptide (RGD) was designed as a dual-receptor targeting drug delivery system to enhance the specificity efficiency of anticancer delivery. Firstly, GO-HA-RGD conjugate characterized reveal its structure morphology. Whereafter, doxorubicin (Dox) model loaded on carrier, which displayed high loading rate (72.9%, GO:Dox (w/w) = 1:1), pH-response sustained release behavior. Cytotoxicity experiments showed that possessed...
Abstract Background Altered adipose tissue (AT) metabolism in cancer‐associated weight loss via inflammation, lipolysis, and white (WAT) browning is primarily implicated from rodent models; their contribution to AT wasting cancer patients unclear. Methods Energy expenditure (EE), plasma, abdominal subcutaneous WAT were obtained men (aged 65 ± 8 years) with cancer, (CWL, n = 27) or without (CWS, 47) loss, weight‐stable non‐cancer (CON, 26). Clinical images assessed for muscle area while...
Non-alcoholic fatty liver disease (NAFLD) has become one of the main chronic diseases worldwide. Protopanaxadiol (PPD), an active compound derived from Gynostemma pentaphyllum, been found able to improve free acid-induced lipid accumulation in hepatocytes. However, efficacy PPD on NAFLD and underlying mechanism remains unknown. In this study, mice were fed with a high-fat diet for 22 weeks induce model, then treated by gavage 8 weeks. Moreover, AML12 HepG2 cells induced acids 24 h, different...
The usage of hollow nerve conduits shows inferior recovery effect on the repair peripheral defects. In this study, a biocompatible and biodegradable pH-induced injectable chitosan–hyaluronic acid hydrogel for growth factor encapsulation sustained release was developed as fillers in lumen conduit to reform its microenvironment regeneration. physicochemical properties were characterized by gelation time, Fourier transform infrared spectroscopy, scanning electron microscopy, compressive...
ABSTRACT Periapical disease, an inflammatory disease mainly caused by dental caries, is one of the most prevalent infectious diseases humans, affecting both children and adults. The infection travels through root, leading to inflammation, bone destruction, severe pain for patient. Therefore, development a new class anti-periapical therapies necessary critical treatment prevention. A small molecule, odanacatib (ODN), which cathepsin K (Ctsk) inhibitor, was investigated determine its ability...
Novel mesoporous silica nanoparticles conjugated with hyaluronic acid and RGD peptide were developed for dual-receptor mediated targeting drug delivery.
Objective To evaluate the trends in disease burden and epidemiological features of liver cancer China while identifying potential strategies to lower burden. Design Observational study based on Global Burden Diseases. Participants Data were publicly available de-identified individuals not involved. Measurement methods measure burden, we extracted data from Health Exchange using metrics prevalence, incidence, mortality disability-adjusted life years (DALYs). Joinpoint negative binomial...
Muscle wasting is the key manifestation of cancer-associated cachexia, a lethal metabolic disorder seen in over 50% cancer patients. Autophagy activated cachectic muscle hosts along with ubiquitin-proteasome pathway (UPP), contributing to accelerated protein degradation and wasting. However, established signaling mechanism that activates autophagy response fasting or denervation does not seem mediate cancer-provoked skeletal myocytes. Here, we show p38β MAPK mediates activation tumor-bearing...
Objectives We aimed to investigate the effect of bifurcation angle (BA) on side branch (SB) occlusion after main vessel (MV) stenting. Background : BA is thought impact risk SB in coronary patients undergoing percutaneous intervention (PCI). Methods A total 1,171 consecutive with 1,200 lesions one stent or provisional two techniques were studied. The divided into low and high groups using median (52°). Multivariate logistic regression analysis was performed identify independent predictors...
The activated c-Jun N-terminal kinase (JNK) specifically combined with SH3 domain-binding protein 5 (Sab) may mediate damage to the mitochondrial respiratory chain. Whether dysfunction induced by JNK/Sab signaling pathway plays a pivotal role in lipotoxic injury of nonalcoholic steatohepatitis (NASH) remains lack evidence. Scoparone, natural compound from Traditional Chinese Medicine herbs, has potential for liver protection and lipid metabolism regulation. However, effect scoparone on NASH...
Abstract Atherosclerosis (AS) is a major pathological factor contributing to the mortality associated with ischemic heart disease and driven primarily by macrophage‐mediated lipid accumulation inflammatory processes. Conventional cardiovascular pharmacotherapies address these mechanisms but often show limited efficacy, highlighting need for innovative agents capable of effectively reducing inflammation minimal toxicity. In this study, decursin, monomer derived from traditional Chinese...
Abstract Background Salvia-Nelumbinis naturalis (SNN), the extract of Chinese herbal medicine, has shown effects on NAFLD. This study aims to explore underlying mechanism SNN for regulating lipid metabolism disorder in NAFLD based SIRT1/AMPK signaling pathway. Methods Male C57BL/6J mice fed with a high-fat diet (HFD) were used establish model. Dynamic changes including body weight, liver serological biochemical indexes, histopathological changes, and protein level AMPK SIRT1 monitored....