A5102789150- Dental Health and Care Utilization
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Gynecological conditions and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Heart Rate Variability and Autonomic Control
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Cardiovascular and exercise physiology
- Dental Erosion and Treatment
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- Dental Trauma and Treatments
- Pulmonary Hypertension Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Retinal Diseases and Treatments
- Ovarian cancer diagnosis and treatment
- Glutathione Transferases and Polymorphisms
- Fluoride Effects and Removal
- Extracellular vesicles in disease
- Reproductive System and Pregnancy
- Cardiac Health and Mental Health
North Sichuan Medical University
2017-2025
Nanchong Central Hospital
2018-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2024-2025
Peking University People's Hospital
2025
Peking University
2025
Central South University
2025
Nanjing Medical University
2020-2024
Jiangsu Cancer Hospital
2022-2024
Chongqing Emergency Medical Center
2024
Chongqing University
2024
Parkinson's disease (PD) is the common age-related neurodegenerative disorder. Sensitive, noninvasive biomarkers that facilitate PD diagnosis and stage assignment are currently unavailable. This study aims to investigate potential of 16 previous reported PD-associated miRNAs as novel for PD. The expression serum was measured by quantitative reverse transcriptase polymerase chain reaction in 138 patients 112 control populations. Analyses were undertaken assess specificity sensitivity predict...
Abstract Background Vascular endothelial growth factor (VEGF)-induced angiogenesis is a critical compensatory response to microvascular rarefaction in the diabetic retina that contributes proliferative retinopathy (PDR). In this study, we sought determine role of specific micro ribonucleic acids (RNAs) (miRs) associated with VEGF patients PDR pathology. Methods RNA sequencing was employed detect differentially circulating miR diabetes mellitus (DM), nonproliferative (NPDR) and PDR....
Depletion of CD8+ T cells is a major obstacle in immunotherapy; however, the relevant mechanisms remain largely unknown. Here, we showed that prostate cancer (PCa) cell-derived exosomes hamper cell function by transporting interleukin-8 (IL-8). Compared to low IL-8 levels detected immune cells, PCa secreted abundance and further accumulated exosomes. The delivery into exhausted through enhanced starvation. Mechanistically, exosomal overactivated PPARα recipient thereby decreasing glucose...
Objectives To investigate uterine fibroid (UF)-associated imaging changes, and their prevalence, incidence potential risk factors in the Chinese population. Design This was a retrospective observational study using health examination data. Setting A physical centre Nanchong, China, between October 2017 December 2020. Participants total of 33 915 women older than 15 years age underwent during period. Primary secondary outcome measures identified entries UF-associated changes through two-round...
To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest reverse naturally occurring buccal caries lesions in children relative positive control alone. Participants from Chengdu, Sichuan Province, China tested three dentifrices: compound, fluoride, as sodium monofluorophosphate, silica base, matched negative without arginine fluoride. Quantitative Light-induced Fluorescence (QLF) was used assess at baseline after 3 6...
Immune microenvironment could affect the biological progress in prostate cancer (PCa) through N6 methyl adenosine (m6A) methylation. The purpose of this study was to investigate crosstalk between m6A methylation and immune explore potential biomarkers improve immunotherapeutic response. Firstly, according 11 differentially expressed genes normal tumor samples, PCa patients were divided into subtype 1 (IMS1) IMS2 based on gene profiles extracted from Cancer Genome Atlas (TCGA) database....
Abstract Radiation is a curative treatment for localized prostate cancer (PCa). Unfortunately, radiotherapeutic efficacy often diminished when patients develop more aggressive or metastatic phenotypes. Recent studies have demonstrated that extracellular vesicles participate in therapeutic resistance by delivering small bioactive molecules, such as non‐coding RNAs. Here, we show stromal cell‐derived (sEVs) facilitate the radioresistance of PCa cells transporting interleukin‐8 (IL‐8). Indeed,...
The objective of this study was to establish the prevalence dentine hypersensitivity (DH) in Chinese urban adults and possible effects smoking on DH.A total 2640 subjects were distributed equally 12 communities Chengdu Xian City, respectively, all age groups (10 years for an group) including same number male female each community. Each subject completed a structured interview who reported symptoms examined with cold air from dental triple syringe order confirm diagnosis DH. Attachment loss...
Abstract Long noncoding RNAs (lncRNAs) are reported to be involved in the pathology of numerous cancers, including neuroblastoma (NB). lncRNA SNHG7 has been recognized as a carcinogen several but its role NB progression remains unknown. Our study revealed that expression was markedly higher tissues than nontumor tissues. Besides, upregulated greatly correlated with poor overall survival patients. Functionally, loss‐of‐function assays demonstrated knockdown inhibited cell proliferation,...
The interaction between programmed death receptor (PD-1) and its ligand (PD-L1) is essential for suppressing activated T-lymphocytes. However, the precise mechanisms underlying PD-L1 overexpression in tumours have yet to be fully elucidated. Here, we describe that RelB participates immune evasion of prostate cancer (PCa) via cis/trans transcriptional upregulation PD-L1.Based on transcriptome results, was manipulated multiple human murine PCa cell lines. Activated CD4+ CD8+ T cells were...
Approximately 25-30% of those affected by colorectal cancer (CRC), the most prevalent gastrointestinal malignancy, develop metastases. The survival rate patients with liver metastasis CRC (CRLM) remains low owing to its unpredictability and a lack biomarkers that can be applied distinguish groups at higher risk for CRLM among CRC. Therefore, our study aimed find predict CRLM. Screening Gene Expression Omnibus database, supported an analysis clinically obtained tissue serum data using qPCR...
Individual metals have been linked to sex hormones disruption, but the associations of mixture are rarely examined among children.A total 1060 participants 6-19-year-old who participated in National Health and Nutrition Examination Survey (2013-2016) were included. Eighteen quantified whole blood urine. Sex measured serum, including testosterone (TT), estradiol (E2), hormone binding globulin (SHBG). In addition, free androgen index (FAI) ratio TT E2 calculated. Bayesian kernel machine...
Objective: The aim of this study was to explore the risk factors that affect implementation innovative technique single-incision laparoscopic appendectomy (solo-SLA) without assistance in patients with complicated appendicitis, goal being improving surgical success rates and reducing incidence complications. Methods: This an observational study. Indications for solo-SLA surgery were as follows: (1) computed tomography or ultrasound findings suggestive acute accompanied by a high white blood...
Objectives: To explore the clinical significance of squamous cell carcinoma antigen (SCC-Ag) and thrombocytosis to predict pelvic lymphatic metastasis (PLM) cervical cancer (SCC) in International Federation Gynecology Obstetrics (FIGO) stages IA-IIA.Methods: A retrospective clinicopathologic review 782 patients a primary cohort three Chinese hospitals from 2010 2015, 407 validation another institution 2015 2017.A receiver operating characteristic curve was used determine optimal SCC-Ag...