A5043930514- MicroRNA in disease regulation
- Spinal Dysraphism and Malformations
- Congenital Anomalies and Fetal Surgery
- Pregnancy and preeclampsia studies
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Reproductive System and Pregnancy
- Mesenchymal stem cell research
- Ferroelectric and Piezoelectric Materials
- Multiferroics and related materials
- Microwave Dielectric Ceramics Synthesis
- Pancreatic and Hepatic Oncology Research
- Hip disorders and treatments
- Cleft Lip and Palate Research
- Prenatal Screening and Diagnostics
- Climate variability and models
- Endoplasmic Reticulum Stress and Disease
- Tissue Engineering and Regenerative Medicine
- Orthopaedic implants and arthroplasty
- Folate and B Vitamins Research
- Circular RNAs in diseases
- Birth, Development, and Health
- Chemical Synthesis and Analysis
- Hydrology and Watershed Management Studies
- Vitamin C and Antioxidants Research
China Medical University
2015-2025
Nanjing Medical University
2016-2025
Shenyang Pharmaceutical University
2024-2025
Shanghai Jiao Tong University
2020-2025
Shanghai Sixth People's Hospital
2024-2025
Chongqing Public Health Medical Center
2025
Chongqing Medical University
2007-2025
Jilin Normal University
2015-2024
University of Science and Technology of China
2024
Sichuan University
2020-2023
Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents significant financial burden for both individuals and healthcare systems. Despite its significance, however, prevalence in Chinese general population remains unknown. This study aimed to investigate NONFH associated risk factors population.A nationally representative survey 30,030 respondents was undertaken from June 2012 August 2013. All participants underwent questionnaire investigation,...
Abstract Intratumoral heterogeneity, including epithelial–mesenchymal transition (EMT), is one major cause of therapeutic resistance. The induction ferroptosis, an iron‐dependent death, has the potential in overcoming this resistance to traditional treatment modalities. However, roles distinct EMT phenotypes ferroptosis remain enigma. This study reports that 3D soft fibrin microenvironment confers colorectal cancer (CRC) cells hybrid phenotype and high level ferroptosis. activation histone...
The Kalman-filter-based algorithms as the mainstream of dynamic state estimation power systems have been extensively used to provide accurate data for system applications. However, few comparisons are made show their advantages and disadvantages. In this paper, four (i.e., extended Kalman filter, unscented cubature ensemble filter) compared differences from implementation complexity, accuracy calculation efficiency, resistance measurement errors, sensitivity scales. Finally, simulation...
Depletion of CD8+ T cells is a major obstacle in immunotherapy; however, the relevant mechanisms remain largely unknown. Here, we showed that prostate cancer (PCa) cell-derived exosomes hamper cell function by transporting interleukin-8 (IL-8). Compared to low IL-8 levels detected immune cells, PCa secreted abundance and further accumulated exosomes. The delivery into exhausted through enhanced starvation. Mechanistically, exosomal overactivated PPARα recipient thereby decreasing glucose...
Abstract Research on the aetiology of neural tube defects (NTDs) has made progress in recent years. However, molecular mechanism apolipoproteins underlying NTDs development remains unclear. This study aimed to investigate function apolipoprotein M (ApoM) pathogenesis and its mechanisms. We demonstrated that ApoM expression was reduced spinal cord samples rat models human fetuses with respectively. Specifically, lack resulted cytosolic localization Elavl2 caused Nnt mRNA degradation, which...
Many bacteria can deliver pathogenic proteins (effectors) through type IV secretion systems (T4SSs) to eukaryotic cytoplasm, causing host diseases. The inherent property, such as sequence diversity and global scattering throughout the whole genome, makes it a big challenge effectively identify full set of T4SS effectors. Therefore, an effective inter-species effector prediction tool is urgently needed help discover new effectors in variety bacterial species, especially those with few known...
The body is unable to repair and regenerate large area bone defects. Moreover, the capacity of articular cartilage very limited. There has long been a lack effective treatments for osteochondral lesions. engineered tissue with biphase synthetic become one hot research fields over past few years. In this study, an integrated biomanufacturing platform was constructed marrow mesenchymal stem cells (BMSCs)/porous tantalum (pTa) associated chondrocytes/collagen membranes (CM) defects in...
Abstract Radiation is a curative treatment for localized prostate cancer (PCa). Unfortunately, radiotherapeutic efficacy often diminished when patients develop more aggressive or metastatic phenotypes. Recent studies have demonstrated that extracellular vesicles participate in therapeutic resistance by delivering small bioactive molecules, such as non‐coding RNAs. Here, we show stromal cell‐derived (sEVs) facilitate the radioresistance of PCa cells transporting interleukin‐8 (IL‐8). Indeed,...
diagnostic role of serum RASSF1Apromoter hypermethylation in gastric and colorectal adenocarcinoma.
Abstract To identify candidate serum molecule biomarkers for the non-invasive early prenatal diagnosis of neural tube defects (NTDs), we employed an iTRAQ-based quantitative proteomic approach to analyze changes in samples from embryonic day (E) 11 and E13 pregnant rats with spina bifida aperta (SBA) induced by all-trans retinoic acid. Among 390 proteins identified, 40 at E11 26 displayed significant differential expression SBA groups. We confirmed 5 ELISA. observed space-time proprotein...
Tantalum rod implantation with vascularized iliac grafting has been reported to be an effective method for the treatment of young patients osteonecrosis femoral head (ONFH) avert need total hip arthroplasty (THA). However, there have unsatisfactory success rates end-stage ONFH. The authors describe a modified technique using bone marrow mesenchymal stem cells (BMMSCs) associated porous tantalum combined A 24 (31 hips) ONFH were treated surgery; ARCO IIIc stage was observed in 19 hips and IV...
Congenital malformations are common birth defects with high neonatal morbidity and mortality. It is essential to find simpler more efficient biomarkers for early prenatal diagnosis. Therefore, we investigated PIWI-interacting RNAs (piRNAs) as potential in plasma-derived exosomes from pregnant women carrying foetuses congenital malformations.Small RNA sequencing was used screen piRNA of five nonsyndromic cleft lip palate (nsCLP) normal foetuses. Differentially expressed piRNAs were verified...
Avascular necrosis of femoral head and nonunion is a major complication after the treatment displaced neck fracture in young adults. The purpose this study was to introduce new technique using biodegradable magnesium screws vascularised iliac grafting for Totally 19 patients with treated were retrospectively reviewed. steps included harvesting vascularized graft, fixing combined implantation. All followed an average 16 months (range: 8–24 months). Clinical radiological outcomes evaluated. In...
Spina bifida aperta are complex congenital malformations resulting from failure of fusion in the spinal neural tube during embryogenesis. Despite surgical repair defect, most patients who survive with spina have a multiple system handicap due to neuron deficiency defective cord. Tissue engineering has emerged as novel treatment for replacement lost tissue. This study evaluated prenatal approach transplanting chitosan–gelatin scaffold seeded bone marrow mesenchymal stem cells (BMSCs) healing...
Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to be positively associated with NONFH. We aimed investigate dysregulating PAI-1 bone marrow mesenchymal stem cells (BMMSCs) and vascular rabbit steroid-induced NONFH.To verify hypothesis that BMMSCs could promote thrombus formation paracrine manner, we collected exosomes from glucocorticoid-treated (GB-Exo)...
The discovery of cell free fetal microRNAs (miRNAs) in maternal circulation has opened up novel probabilities for non-invasive prenatal diagnosis. This study aims to investigate circulating miRNAs as potential biomarkers the serum pregnant women with congenital heart defect (CHD) fetuses.A total 110 including 50 CHD cases and 60 healthy controls were included this study. miRNA microarray followed by real-time PCR was used explore expression. Receiver operating characteristic (ROC) curves...
Abstract Impaired autophagy and excessive apoptosis disrupt cellular homeostasis contribute to neural tube defects (NTDs), which are a group of fatal disabling birth caused by the failure closure during early embryonic development. However, regulatory mechanisms underlying NTDs outcomes remain elusive. Here, we report role transcription factor nuclear I-C (NFIC) in maintaining NTDs. We demonstrated that abnormally elevated levels NFIC mouse model can interact with miR-200b promoter, leading...
The life satisfaction (LS) of individuals among older adults with diabetes should not be neglected. However, current research provides limited insight into the LS in China. Therefore, primary objective this study is to assess status China, delve factors influencing it, and identify key factors. This selected 1,304 patients from Chinese Longitudinal Healthy Longevity Survey (CLHLS) database for analysis. A multivariate logistic regression model was used analyze diabetic patients, a random...
Nonsyndromic cleft lip with palate (nsCLP) is a common birth defect disease. Current diagnostic methods comprise fetal ultrasound images, which are mainly limited by position and technician skills. We aimed to identify reliable maternal serum lipid biomarkers diagnose nsCLP. Eight-feature selection were used assess the dysregulated lipids from untargeted lipidomics in discovery cohort. The robust rank aggregation algorithm was applied on these selected lipids. data subsequently processed...