A5101635682- Bone and Joint Diseases
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Glaucoma and retinal disorders
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Orthopedic Infections and Treatments
- Extracellular vesicles in disease
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Retinal and Macular Surgery
- Dermatologic Treatments and Research
- Ophthalmology and Visual Impairment Studies
- Lower Extremity Biomechanics and Pathologies
- Bone fractures and treatments
- Dermatological and COVID-19 studies
- MicroRNA in disease regulation
Affiliated Zhongshan Hospital of Dalian University
2016-2025
Jiangmen Central Hospital
2025
Second Military Medical University
2024
Changhai Hospital
2024
Yanshan University
2023
Shandong University
2023
China-Japan Friendship Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Guangdong Academy of Medical Sciences
2019-2022
Southern Medical University
2013-2022
Aims To investigate the function and corresponding neurovascular structures in patients with diabetes without clinically detectable retinopathy. Methods Sixty-six type 2 retinopathy (NDR) 62 healthy controls were recruited. The 16 32 Tds flicker electroretinography (ERG) was performed using a mydriasis-free, full-field ERG recording device (RETeval). vessel density (VD) of superficial capillary plexus (SCP) deep (DCP), FD300 ganglion cell complex (GCC) thickness macula quantified optical...
The body is unable to repair and regenerate large area bone defects. Moreover, the capacity of articular cartilage very limited. There has long been a lack effective treatments for osteochondral lesions. engineered tissue with biphase synthetic become one hot research fields over past few years. In this study, an integrated biomanufacturing platform was constructed marrow mesenchymal stem cells (BMSCs)/porous tantalum (pTa) associated chondrocytes/collagen membranes (CM) defects in...
Transforming growth factor β1 (TGF‑β1) has been suggested to be a candidate cytokine in the field of bone tissue engineering. Cytokines serve important roles engineering, particularly repair damage; however, underlying molecular mechanisms remain unclear. In present study, effects TGF‑β1 on osteogenesis and motility hFOB1.19 human osteoblasts were demonstrated via phenotype gene expression cells. Additionally, role phosphatidylinositol 3‑kinase/protein kinase B/mammalian target rapamycin/S6...
Tantalum rod implantation with vascularized iliac grafting has been reported to be an effective method for the treatment of young patients osteonecrosis femoral head (ONFH) avert need total hip arthroplasty (THA). However, there have unsatisfactory success rates end-stage ONFH. The authors describe a modified technique using bone marrow mesenchymal stem cells (BMMSCs) associated porous tantalum combined A 24 (31 hips) ONFH were treated surgery; ARCO IIIc stage was observed in 19 hips and IV...
Purpose: To develop a deep learning (DL) model to detect morphologic patterns of diabetic macular edema (DME) based on optical coherence tomography (OCT) images. Methods: In the training set, 12,365 OCT images were extracted from public data set and an ophthalmic center. A total 656 another center for external validation. The presence or absence three DME, including diffused retinal thickening, cystoid edema, serous detachment, was labeled with 1 0, respectively. DL trained DME. occlusion...
Metal plates have always been the gold standard in clinic for internal fracture fixation due to their high strength advantages. However, elastic modulus can cause stress shielding and lead bone embrittlement. This study used an electron beam melting method prepare personalized porous Ti6Al4V (pTi) plates. Then, chemical vapor deposition (CVD) technology coats tantalum (Ta) metal on pTi The prepared Ta-coated plate has similar cortical bone, no occurred. In vitro experiments showed that...
Porous tantalum metal with low elastic modulus is similar to cancellous bone. Reticulated vitreous carbon (RVC) can provide three-dimensional pore structure and serves as the ideal scaffold of coating. In this study, biocompatibility domestic porous was first successfully tested bone marrow stromal stem cells (BMSCs) in vitro for tissue repair vivo. We evaluated cytotoxicity RVC coating using BMSCs. The morphology, adhesion, proliferation BMSCs were observed via laser scanning confocal...
Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to be positively associated with NONFH. We aimed investigate dysregulating PAI-1 bone marrow mesenchymal stem cells (BMMSCs) and vascular rabbit steroid-induced NONFH.To verify hypothesis that BMMSCs could promote thrombus formation paracrine manner, we collected exosomes from glucocorticoid-treated (GB-Exo)...
Abstract Fracture is one of the most common traumatic diseases in clinical practice, and metal plates have always been first choice for fracture treatment because their high strength. However, bone elastic modulus do not match biomechanics human bone, which adversely affects callus formation healing. Moreover, complex microenvironment body can induce corrosion metallic materials release toxic ions, reduces biocompatibility plate, may necessitate surgical removal implant. In this study,...
Background Osteonecrosis of the femoral head (ONFH) often affects young active adults and leads to destruction hip joint disabling arthritis. Several procedures have been developed arrest progress osteonecrosis postpone procedure total replacement especially in patients. The aim this multicenter study was analyze results use vascularized iliac bone flap transfer for management ONFH. Methods From January 1985 December 2012, a 2190 patients (2690 hips) with mean age 43.15 years (ranging from...
Background To investigate retinal neurovascular structural changes in patients with ischemic stroke (IS) using optical coherence tomography angiography (OCTA). Materials and Methods The cross-sectional study was conducted Guangdong Provincial People’s Hospital, China, consisting of 159 eyes from IS 109 age-matched control subjects. Retinal microvascular parameters including the vessel density (VD) superficial capillary plexus (SCP), deep (DCP) radial peripapillary (RPC), neural such as...
The treatment of acetabular defects is one the most difficult challenges revision total hip arthroplasty (RTHA), and tantalum regarded as a promising bone substitute material. This study aims to investigate effectiveness 3D printed augment used in RTHA for defect.A retrospective analysis clinical data seven patients who had undergone was carried out using from January 2017 December 2018. CT were exported Mimics 21.0 software (Materialise, Leuven, Belgium), defect designed, then implanted...
In the field of orthopedics, defects in large bones have proven challenging to resolve. The aim present study was address this problem through combination tantalum metal (pTa) with exosomes derived from bone marrow mesenchymal stem cells (BMSCs), which potential enhance regeneration full thickness femoral rats. Cell culture results demonstrated that improved proliferation and differentiation BMSCs. Following establishment a supracondylar defect, pTa were implanted into defect area. Results...
Lung adenocarcinoma (LUAD) is a highly malignant tumor with the highest mortality rate among all cancers. Early diagnosis and prognosis are important factors in treatment. Hepatic leukemia factor (HLF) thought to be closely associated lung cancer metastasis. It downregulated tissues negatively correlated number of metastasis-activating circulating cells (CTCs) peripheral blood patients. In this study, we analyzed data from LUAD samples TCGA found that HLF was significantly upregulated EGFR...
The aim of this report is to present our experience on the use digital subtraction angiography (DSA) in selection vascularized greater trochanter bone grafting for treatment osteonecrosis femoral head (ONFH) early stages. Between January 2005 and June 2007, DSA was used evaluate blood perfusion stages ONFH 32 patients (45 hips). There were 18 males 14 females with an average age 30 years old. Twenty-one hips ARCO stage I, 24 II. arterial supply insufficiency found 22 by DSA, venous stasis 23...